MTRX31 obesity metabolic modulator program
preclinicalRestore healthy mitochondrial metabolism in high-risk, metabolically unhealthy obesity by rebalancing carbohydrate and fat oxidation, reducing ectopic fat, preserving lean mass, and improving insulin sensitivity.
First-in-class small-molecule metabolic modulator evaluated in murine diet-induced obesity models, including thermoneutrality studies measuring bodyweight loss and substrate oxidation shifts.
Preclinical publications and site-disclosed pipeline listing describe MTRX31/Myo-004/Myo4 activity in diet-induced obesity models.
Reported preclinical findings include bodyweight loss in diet-induced obese mice at thermoneutrality by switching metabolism from fat to carbohydrate oxidation, with characterization as anti-obesogenic and muscle-preserving.