News
Longevity, biotech, and science-funding news.
2,001 dispatches in the archive16 September 2026
1 dispatch
15 September 2026
17 dispatches
Preprint: cystine deficiency altered metabolism in mice lacking CTH, a cysteine-synthesizing enzyme
Cystine deprivation, not methionine, drives the metabolic benefits of restricted diets in mice lacking the cysteine-synthesizing enzyme CTH.
Review links aging neuron vulnerability to RNA processing failures
A review in Trends in Cell Biology links age-related failures in RNA processing and RNA-binding proteins to increased neuronal vulnerability and neurodegeneration.
Preprint: an algorithm found the optimal interval between nerve and brain stimulation faster in adult recordings
A Gaussian process algorithm identified the optimal nerve-to-cortex stimulation interval in adults within a median of 10 stimulus pairs, halving the time needed vs. random search.
IIHS: Waymo robotaxis in four cities had 68% fewer comparable crashes per mile driven than human drivers
IIHS found Waymo robotaxis had 68% fewer comparable crashes per mile than human drivers across four U.S. cities, with injury crashes down 81%.
Repeat brain MRIs found similar rates of gray matter change regardless of menopausal transition
A Nature Communications study found no significant difference in gray matter change rates during menopause compared to stable-status peers, unlike puberty and pregnancy.
Two connectivity gradients discovered in the substantia nigra, one linked to aging and motor function and the other to memory and mood
Researchers identified two stable connectivity gradients in the substantia nigra: one linked to aging and motor function, another to memory and mood.
The founder of Nucleus Genomics proposes the term "genetic optimization industry" for companies building tools and services that allow parents to influence the genetic traits of their future children
Kian Sadeghi of Nucleus Genomics coins "genetic optimization industry" to describe companies using embryo selection, gene editing, and IVG to influence children's traits.
Review of 435 studies: biological age measures often diverge
A review of 435 studies finds that biological age estimates depend heavily on the markers chosen and the population in which they were validated.
Unpublished conference data link machine perfusion of donor livers to lower biological age estimates
Machine perfusion of donor livers yields lower biological age estimates than ice storage, with epigenetic and gene-expression data showing roughly 30% difference after age adjustment.
Five pharma companies fine-tuned a protein-ligand structure prediction model on proprietary data and improved accuracy on a held-out test set
Five pharma companies used federated learning to fine-tune OpenFold3 on 20,167 proprietary protein-ligand structures, boosting co-folding accuracy from 35.6% to 52.1%.
Biotech company GenScript plans to allocate 70% of expected share placement proceeds to AI-powered automated drug discovery laboratories
GenScript raised ~HK$2.33B via share placement, directing 70% toward AI-powered automated drug discovery laboratories and related infrastructure.
Preprint: GenEHR estimates five-year first cancer diagnosis risk from electronic health records
GenEHR uses sequential EHR data to estimate five-year first cancer diagnosis risk, identifying high-risk individuals for targeted screening across 8–17 cancer types.
Mitochondria in presynaptic terminals linked to poorer rule switching in aged mice
Mitochondria in presynaptic terminals of the medial prefrontal cortex correlate with poorer rule-switching in aged mice; MitoQ treatment improved performance.
ARPA-H Awards Contracts for AI That Manages Heart Failure Patients Between Clinic Visits
ARPA-H awarded first-phase contracts to Atman Health, Tempus AI, and UpDoc to build AI agents managing heart failure patients between clinic visits and pursuing FDA device authorization.
Perspective article proposes assessing tissue repair and tumor promotion risk within a single testing framework
A new framework proposes testing tissue repair and tumor promotion risk together, using the same cellular signaling pathways as shared readouts.
The PHAROS preprint presents an algorithm that searches for drug sequences toward a desired cell state
PHAROS is an algorithm that takes current and target cell states as input and searches for optimal drug sequences to drive the transition, validated on lung cancer and cancer cell lines.
A preprint reports that a single substitution in CD27 enhanced anti-CD70 CAR-T cells in cell culture and mouse experiments
A single amino acid substitution (N88A) in CD27 doubled CAR-T cell binding stability to CD70, eliminating detectable tumor in an 85-day mouse leukemia model.
14 September 2026
6 dispatches
Roko Mijic suggests rapid growth in AI capabilities could outpace human governance
Roko Mijic warns that AI capabilities growing at 1,000–10,000% annually could bypass fragile legal and political institutions before humans can direct AI toward medicine and welfare.
Sinclair and Brenner disagree on why SIRT1-activator drug programs were discontinued
Sinclair and Brenner publicly clash over why GlaxoSmithKline's SIRT1-activator drug programs were discontinued — industry failure versus safety and efficacy doubts.
Biogerontologist Matt Kaeberlein Criticized Genflow's Press Release Claiming to 'Reverse Aging' in Dogs
Matt Kaeberlein questions Genflow's pre-data press release claiming its gene therapy 'reversed aging' in dogs, pending full results on October 2.
Norn Group opens applications for its updated Talent Bridge program for people outside the US who want to work on aging
Norn Group opens applications for Talent Bridge, offering non-US aging researchers project funding, mentoring, and support to relocate to the US.
ChASE37 helped human neural cells survive in rat brains after stroke
ChASE37 enabled human neural progenitor graft survival in rat stroke lesions for four weeks, while cells alone produced no detectable graft.
Commentary proposes treating donor organs during machine perfusion before transplantation
A commentary proposes delivering FXT-001 to donor organs during machine perfusion to limit oxidative injury and assess treatment effects before transplantation.