LEQEMBI cerebral and retinal amyloid observational study
exploratoryresearch program · medium · Wed Apr 24 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Determine whether retinal Aβ plaques and vascular findings correlate with brain amyloid-related imaging abnormalities in mild cognitive impairment due to Alzheimer's disease during LEQEMBI exposure.
Proof-of-concept observational clinical study comparing cerebral and retinal amyloid and vascular findings.
ClinicalTrials.gov record NCT06400368 was published on 2024-04-24.
Afina retinal imaging
exploratorybiomarker · high
Use retinal imaging to support earlier detection, prediction, and monitoring of cognitive decline and Alzheimer's disease progression.
Retinal amyloid imaging using amyloid-binding fluorophore curcumin with laser ophthalmoscopy / scanning laser ophthalmoscopy fluorescence imaging; analyses include retinal amyloid burden, perivascular amyloid plaque distribution, and vascular features such as venular tortuosity.
2024 exploratory analysis reported retinal peri-arteriolar versus peri-venular amyloidosis patterns and correlations with dementia rating, MoCA, hippocampal volume, and white matter hyperintensity count.
Studies reported that retinal amyloid and vascular measures correlate with cognitive impairment, verbal memory loss, hippocampal atrophy, and other neurocognitive or neuroimaging measures; larger longitudinal studies with AD biomarker confirmation were described as warranted.
BrainHealth Clinic
undisclosedplatform · high
Deliver telehealth-based cognitive care as part of earlier detection and ongoing management for cognitive and neurodegenerative disease.
Telehealth care model for cognitive assessment, neurology access, and longitudinal management.
Listed in the supplied site analysis as one component of NeuroVision Imaging's BrainHealth Platform.
BrainHealth Platform
undisclosedplatform · high
Provide integrated infrastructure for earlier detection and longitudinal care in neurodegenerative disease across primary care, biomarker testing, retinal imaging, neurology access, and ongoing management.
Integrated platform combining telehealth cognitive care, retinal imaging, and blood biomarker diagnostics.
Identified in the supplied site analysis as NeuroVision Imaging's integrated platform spanning BrainHealth Clinic, Afina, and Duritect.
Duritect blood biomarker diagnostics
undisclosedbiomarker · medium
Develop blood biomarker diagnostics for earlier detection of neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, and ALS indications listed in the supplied materials.
Blood biomarker diagnostic platform acquired from Durin Life Sciences; supplied disambiguation keywords include pTau-217 and NfL.
Identified in the supplied site analysis as NeuroVision Imaging's blood biomarker diagnostics acquired from Durin Life Sciences.
