Mitochondrial Complex I modulator regenerative medicine platform
preclinicalPromote and regulate tissue repair and maintenance across organs and disease settings by using mitochondrial Complex I as a signaling checkpoint for context-dependent repair responses.
Novel inhibitors/modulators of mitochondrial Complex I profiled in vitro in myeloid and fibroblast cells and tested in mouse models of collagen-induced arthritis and bleomycin-induced lung fibrosis.
Publication of preclinical proof-of-concept showing Complex I inhibitor-driven tissue repair concurrent with control of inflammation.
NIC1 treatment reduced inflammation and bone pathology in collagen-induced arthritis while improving anatomically appropriate osteoid production; in bleomycin-induced lung fibrosis, treatment reduced fibrosis and inflammation and mobilized alveolar epithelial repair responses.