Collagen amino acid composition supplementation
exploratoryresearch program · medium · Thu Jul 03 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess whether a defined collagen amino acid composition can improve healthy aging markers, skin features, biological age, healthspan, and lifespan.
Supplementation with a ratio of three glycine to one proline to one hydroxyproline; tested in C. elegans, human fibroblasts, aged mice, and a human clinical observational trial.
Human observational trial registered ISRCTN93189645 on 2025-07-03 reported improved skin features within three months and biological-age reduction within six months.
Reported increased motility-healthspan and lifespan in C. elegans, improved collagen homeostasis in human fibroblasts, improved grip strength and reduced age-related fat accumulation in mice, and a 1.4-year biological-age reduction in humans at six months.