Miamind tACS safety and feasibility study in healthy participants
phase 1research program · high · Wed Dec 27 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess the safety and feasibility of repeated transcranial alternating current stimulation using the Miamind Neurostimulator in healthy participants, to support later Alzheimer’s disease trials.
Clinical trial of repeated tACS delivered by the Miamind Neurostimulator in healthy participants.
ClinicalTrials.gov record NCT05999916 published on 2023-12-27; study registered on SNCTP and ClinicalTrials.gov, with ethics approval on 2023-08-14 and Swissmedic approval on 2023-12-20 reported in the publication abstract.
Publication abstract reports electrical and mechanical feasibility and a healthy-subject clinical trial showing improved comfort and increased willingness for home use.
Miamind early-stage Alzheimer’s disease clinical trial
exploratoryresearch program · high
Evaluate the MIAMIND electrical neurostimulator in patients with early-stage Alzheimer’s disease.
Randomized, sham-controlled clinical trial in early-stage Alzheimer’s disease patients, supported by Innosuisse funding.
2026 site news says the MIAMIND neurostimulator will be evaluated in a randomized, sham-controlled clinical trial funded by Innosuisse.
Miamind Neurostimulator
undisclosedplatform · high
Provide personalized, non-invasive, home-based transcranial electrical stimulation and EEG for people with cognitive disorders.
Patient-specific 3D-printed cap based on individual anatomical MRI scans, with up to 34 freely placeable electrodes combining tES and EEG.
Commercial-stage device described as developed and marketed by Bottneuro; clinical evaluation programs are ongoing or planned.
Published device work reports feasibility of patient-specific caps, integrated brush electrodes, electronics in a neckpiece, and improved comfort and willingness for home use in a healthy-subject clinical trial.
NENI - Nano Engineered Neural Interfaces
exploratoryresearch program · medium
Advance nano engineered neural interfaces.
Not disclosed in supplied material beyond the project title and grant description.
2019 Gebert Rüf support of CHF 300,000 for the NENI project.
Personalized flexible-electrode tES targeting program
preclinicalresearch program · high
Increase target engagement and control stimulation dose for cortical targets relevant to Alzheimer’s disease, including the left angular gyrus and default mode network nodes.
Biophysical modeling using individual brain imaging and digitally designed 3D-printed tES caps with flexible electrode positioning; simulations benchmark personalized flexible montages against conventional montage approaches.
2025 NeuroImage publication reports in silico proof-of-concept for customized electrode positioning.
Personalized flexible electrode placement improved tunable intensity and focality-intensity control, reduced target-intensity variance versus reference-model optimization, and increased target engagement when available electrode positions increased from 32 to around 86.
