AISA d-Limonene RISTOMED intervention
exploratoryresearch program · high · Thu Mar 19 2020 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate whether AISA d-Limonene as part of a healthy diet intervention affects inflammation-associated quality of life, anxiety, and depressive symptoms in older adults.
Randomized open-label 56-day dietary intervention trial in healthy adults aged 65-80, with one arm receiving healthy diet plus AISA d-Limonene.
RISTOMED trial results were published in Nutrients in 2020.
In the AISA d-Limonene arm, CES-D depressive symptom score decreased by 42.8% overall and by 52.2% in subjects with medium/high inflammation; mental HRQoL improved, while anxiety and physical HRQoL did not change.