C-BE4Zprecision nutrition, synthetic biology, clinical research
0-100 chain-logic scale · 15 dimensions · scored on public evidence
Evaluate the safety of two doses of spermidine in healthy males using adverse events and serious adverse events as safety outcomes.
Clinical study of spermidine supplementation in healthy males assessing occurrence of adverse events and serious adverse events.
ClinicalTrials.gov record published for the bioavailability and safety study.
Support safety assessment of high-purity spermidine trihydrochloride produced using an engineered Saccharomyces cerevisiae strain as a dietary source of spermidine.
Authoritative guideline and GLP-compliant in vitro genotoxicity assays, including bacterial reverse mutation and mammalian micronucleus assays, plus a 90-day oral dietary toxicity study in rats.
Toxicological assessment published for spermidine trihydrochloride produced using engineered Saccharomyces cerevisiae.
Spermidine trihydrochloride was non-genotoxic in vitro, and no adverse effects were reported in the 90-day rat oral toxicity study up to the highest dose tested; subchronic NOAEL was 728 mg/kg bw/day.
Evaluate the safety, tolerability, metabolic effects, and polyamine homeostasis effects of high-purity spermidine supplementation in healthy older men as a basis for further research into human health and ageing biology.
Randomized, double-blind, within-subject placebo-controlled human trial administering 40 mg/day high-purity spermidine trihydrochloride for 7 and 28 days in 37 healthy men aged 50-70.
Exploratory clinical trial results were published reporting safety and tolerability of 40 mg/day hpSPD for up to 28 days.
No significant changes in clinical, lipid, chemistry, or hematological parameters versus placebo were reported; compliance was high; no study product-related adverse events were reported; serum and urine polyamine concentrations did not substantially change.
Develop precision nutrition interventions and supplements intended to enhance healthy lifespans and address condition-specific consumer health benefits and chronic health conditions associated with ageing.
Integration of biology, bioengineering, clinical research, data analytics, and synthetic biology to develop nutrition-based interventions.
Company described as early-commercial stage with a focus on precision nutrition interventions and supplements for healthy ageing.