C-CNWUpharmaceutical therapies, gene therapies, aging repair
0-100 chain-logic scale · 15 dimensions · scored on public evidence
Develop pharmaceutical and gene therapies to repair and reverse pathological changes of aging.
Undisclosed pharmaceutical and gene-therapy approaches described at the company-program level.
Company site states that Legendary Pharmaceuticals is developing pharmaceutical and gene therapies and includes a research program section.
Develop therapies to remove or reverse extracellular glycation and crosslink damage in long-lived extracellular proteins such as collagen and elastin, addressing age-related tissue stiffening and organ dysfunction.
Therapy-development research focused on extracellular matrix turnover enhancement and discovery of agents that can break prevalent glycation crosslinks such as glucosepane and K2P.
A 2006 Rejuvenation Research publication described the therapeutic rationale and two proposed development approaches for extracellular glycation crosslink removal.
Known crosslink breakers such as alagebrium were described as only partly effective, and no agent had been found to break prevalent glucosepane and K2P crosslink structures at the time of publication.