C-H9YFBooster Therapeutics
20S proteasome activation, small molecules, protein homeostasis
repairingsmall molecule
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Loading section...0-100 chain-logic scale · 15 dimensions · scored on public evidence
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C-H9YFC-H9YF20S proteasome activation, small molecules, protein homeostasis
0-100 chain-logic scale · 15 dimensions · scored on public evidence
Booster Therapeutics states that aging and many age-related diseases are driven in part by a collapse of cellular homeostasis, especially the age-related loss of the cell's ability to eliminate damaged components. The company argues that treating diseases one by one is the wrong paradigm and that targeting the cellular machinery that regulates and maintains homeostasis can prevent and treat diseases of aging. It further suggests that preserved homeostatic function in centenarians and long-lived animals, and its association with longevity across organisms, supports this therapeutic approach.
SourceBooster Therapeutics states that many diseases of aging should not be treated only as separate conditions, because aging itself is driven in part by a collapse of cellular homeostasis. The company believes that with age, cells lose the ability to remove damaged cellular components, causing dysfunctional material to accumulate and destabilize normal cellular function. It further asserts that preserving or modulating the cellular machinery that regulates homeostasis is linked to longevity across organisms and could help treat currently untreatable diseases.
SourceBooster Therapeutics states that aging and many age-related diseases are driven in part by a collapse of cellular homeostasis, especially the declining ability of cells to eliminate damaged cellular components. The company argues that treating diseases one by one contributes to rising age-related disease burden, and that a better approach is to target the cellular system that regulates and maintains homeostasis. It further claims that this machinery declines with age in healthy humans, remains steadier in centenarians and long-lived animals, and that modulating it is linked to longevity across multiple organisms, leading Booster to believe such modulation can help patients with currently untreatable diseases.
SourceBooster Therapeutics states that aging and many age-related diseases are driven by a collapse of cellular homeostasis, especially the age-related loss of the cell’s ability to eliminate damaged components. The company believes treating diseases one by one contributes to rising age-related burden, and that targeting the cellular machinery that regulates and maintains homeostasis can prevent and treat diseases of aging. It further asserts that this machinery declines with age in healthy humans but remains stable in centenarians and long-lived animals, and that modulating it is linked to longevity across organisms.
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