PP405
phase 2drug program · high · Wed Oct 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Treat androgenetic alopecia by reactivating dormant hair follicle stem cells to promote hair growth.
Topically applied small molecule designed to shift hair follicle stem cell metabolism and reactivate dormant follicles without detectable systemic exposure; evaluated in a two-part clinical study with randomized controlled safety/PK treatment followed by open-label extension.
Phase 2a study in androgenetic alopecia; company plans progression into Phase 3 trials in 2026.
ClinicalTrials.gov record describes the study as validating Phase 1 safety results and characterizing longer-term safety and pharmacokinetics; supplied material reports no efficacy results.
PP405 hair loss program
phase 2drug program · high · Wed Oct 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Develop a non-hormonal, non-invasive topical regenerative medicine for androgenetic alopecia by reactivating dormant hair follicle stem cells across genders, skin types, and hair types.
Topical small-molecule treatment targeting hair follicle stem cell metabolism, including inhibition of pyruvate oxidation/metabolic switching, evaluated in adults with androgenetic alopecia. The Phase 2a study includes a randomized controlled safety and pharmacokinetic portion followed by an open-label extension.
Phase 2a study in androgenetic alopecia reported positive results, with progression into Phase 3 trials planned for 2026.
The supplied material states that the Phase 2a study reported positive results. ClinicalTrials.gov describes the study as validating Phase 1 safety results, characterizing longer-term safety and pharmacokinetics, and evaluating 28 days of blinded treatment followed by 3 months of open-label treatment.
Hair follicle stem cell metabolic activation research
exploratoryresearch program · high · Mon Jan 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Identify and validate metabolic mechanisms that activate hair follicle stem cells and stimulate the hair cycle in alopecia models.
Research on inhibition of pyruvate oxidation, lactate dehydrogenase activity, and related metabolic pathways in human hair follicle stem cells ex vivo and alopecia models; publications should be linked downstream through company_project_publications.
Multiple site-listed scientific publications support the approach, including 2024 work on inhibition of pyruvate oxidation activating human hair follicle stem cells ex vivo.
Site-listed publication titles indicate that inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo, can stimulate the hair cycle in alopecia models, and that lactate dehydrogenase activity drives hair follicle stem cell activation.
Hair follicle stem cell metabolism research program
exploratoryresearch program · medium · Mon Jan 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Investigate metabolic mechanisms that activate human hair follicle stem cells and stimulate the hair cycle in alopecia models.
Research on inhibition of pyruvate oxidation and lactate dehydrogenase activity as mechanisms for hair follicle stem cell activation and hair-cycle stimulation.
Company-listed science publications include 2024 work on inhibition of pyruvate oxidation activating human hair follicle stem cells ex vivo, plus related work on pyruvate oxidation inhibition in alopecia models and lactate dehydrogenase activity driving hair follicle stem cell activation.
Supplied publication titles indicate that pyruvate oxidation inhibition activates human hair follicle stem cells ex vivo, can stimulate the hair cycle in alopecia models, and that lactate dehydrogenase activity drives hair follicle stem cell activation.
Hair follicle stem cell metabolic activation research program
exploratoryresearch program · medium
Identify and validate metabolic mechanisms that activate hair follicle stem cells for hair growth and alopecia treatment.
Research on inhibition of pyruvate oxidation, lactate dehydrogenase activity, and ex vivo or model-system stimulation of the hair cycle.
Pelage lists multiple stem-cell biology publications, including a 2024 Journal of Investigative Dermatology item on inhibition of pyruvate oxidation activating human hair follicle stem cells ex vivo.
Supplied titles indicate inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo and stimulates the hair cycle in alopecia models; lactate dehydrogenase activity is reported as driving hair follicle stem cell activation.
