Next-generation epigenetic clock intervention evidence review
exploratoryresearch program · medium · Thu Jan 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Catalog human interventions reported to decrease next-generation epigenetic aging clocks and compare clock responsiveness.
Systematic searches of human studies reporting intervention effects on next-generation epigenetic clocks.
2026 Frontiers in Genetics article identified 41 human studies across pharmaceutical, lifestyle, supplementation, clinical, and psychosocial interventions.
Reported interventions decreasing epigenetic age included exercise, plant-rich diet, semaglutide, caloric restriction, ketamine, omega-3 fatty acids, multivitamin-multimineral supplementation, umbilical cord plasma, and pitavastatin; nicotinamide riboside, rapamycin, senolytics, and others showed no detectable effect; plasmapheresis and other therapeutics accelerated epigenetic aging.
Buccal-customized epigenetic clocks for socioeconomic and health disparities
exploratoryresearch program · medium · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Investigate socioeconomic and health disparities using epigenetic clocks customized for buccal samples.
Application of buccal-customized epigenetic clocks to disparity-related analyses.
2025 GeroScience publication listed in supplied materials.
Buccal methylomic explainable aging clocks and lifestyle classifiers
exploratoryresearch program · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Use buccal methylomic data to build explainable aging clocks and classifiers or regressors for lifestyle and demographic factors.
Computational modeling of buccal DNA methylation data for aging-clock construction and lifestyle or demographic prediction.
2025 Frontiers in Genetics publication listed in supplied materials.
CheekAge buccal epigenetic aging clock
exploratorybiomarker · high · Mon Jan 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Develop and validate a next-generation epigenetic aging clock optimized for cheek-swab samples and associated with lifestyle, health, disease, and mortality-related outcomes.
Buccal methylomic data, MethylationEPIC profiling, CpG filtering, CpG clustering, simulated annealing, and clock ensembling.
2024 publications reported CheekAge as associated with lifestyle and health and predictive of mortality in human blood.
CheekAge showed strong correlation with age, high test-retest reproducibility, associations with BMI, smoking, alcohol intake, lifestyle and health factors, and mortality prediction in human blood.
CheekAge
exploratorybiomarker · medium
Develop and validate a next-generation epigenetic aging clock optimized for non-invasive cheek swab samples and associated with lifestyle, health, and mortality-related signals.
DNA methylation clock trained on MethylationEPIC data from 8,045 diverse adult buccal samples using CpG filtering, CpG clustering, simulated annealing, and clock ensembling; later applied to longitudinal blood cohorts for mortality association testing.
Published validation work reported that CheekAge was significantly associated with mortality in the Lothian Birth Cohorts and performed better than tested first-generation clocks.
CheekAge showed strong correlation with age, high test-retest reproducibility, associations with lifestyle and health factors including BMI, smoking, and alcohol intake, and a mortality hazard ratio of 1.21 per one standard deviation in a longitudinal blood dataset.
Epigenetic Aging Intervention Evidence Review
exploratoryresearch program · low
Identify human interventions reported to decrease next-generation epigenetic aging clocks and compare clock responsiveness across studies.
Systematic searches identifying 41 human studies of pharmaceutical, lifestyle, supplementation, non-pharmaceutical clinical, and psychosocial interventions measured against next-generation epigenetic clocks.
A 2026 Frontiers in Genetics review summarized interventions associated with decreased, null, or accelerated epigenetic aging clock effects.
Reported interventions associated with decreased epigenetic age included exercise, plant-rich diet, semaglutide, caloric restriction, ketamine, omega-3 fatty acids, multivitamin-multimineral supplementation, umbilical cord plasma, and pitavastatin; nicotinamide riboside, rapamycin, and senolytics showed no detectable effect in the reviewed evidence.
Personalized longevity insights platform
undisclosedplatform · medium
Provide personalized healthspan and longevity insights based on epigenetic testing and related health information.
Digital interpretation layer connected to cheek-swab epigenetic age testing and personalized recommendations or insights.
Listed in supplied site analysis as part of Tally Health's offering.
TallyAge Test
undisclosedconsumer product · high
Benchmark and track cellular aging for consumers using an epigenetic age test.
At-home cheek swab assay for epigenetic age measurement, presented as part of Tally Health's healthy aging offering.
Commercially described on the Tally Health site as a cheek-swab test for benchmarking and tracking cellular aging.
Tally Health longevity supplement formulations
undisclosedconsumer product · medium
Support healthy aging pathways related to energy, metabolism, sleep, focus, immunity, and cellular health.
Dietary supplement formulations; supplied evidence links include reviews of apigenin and glycine in aging-related biology.
Listed in supplied site analysis as Tally Health longevity supplement formulations.
Supplied publication abstracts describe apigenin as connected to sleep and aging biology and glycine as having aging-related evidence and mechanisms, but no product-specific clinical results were supplied.
Tally Health Membership and Personalized Insights
undisclosedplatform · medium
Provide membership-based personalized insights and action plans for healthy aging and longevity.
Consumer membership platform combining epigenetic testing, supplements, and personalized insights or action plans.
Tally Health site describes membership-based personalized insights and action plans as part of the offering.
Tally Health Supplements
undisclosedconsumer product · high
Support healthy aging through science-backed supplement formulations targeting energy, metabolism, cellular health, sleep, focus, immunity, NAD+ support, and inflammaging.
Consumer supplement formulations positioned around longevity and healthspan support.
Tally Health site describes supplements as part of its healthy aging product offering.
