C-VFGBBolden Therapeutics
neurogenesis, antisense oligonucleotides, exon-skipping
modulatingrna therapeutic
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C-VFGBC-VFGBneurogenesis, antisense oligonucleotides, exon-skipping
0-100 chain-logic scale · 15 dimensions · scored on public evidence
Bolden Therapeutics states that promoting neurogenesis in the adult brain is a key therapeutic strategy for central nervous system diseases. The company says its founders identified a molecular pathway that can drive the birth of new neurons, and it presents diminished neurogenesis as a contributor to cognitive dysfunction and memory impairment across neurodegenerative and neurological conditions. It further states that neurogenesis is important for learning, memory, and functional recovery after brain injury and ischemic stroke, supporting its view that neurogenesis-promoting therapies could have broad clinical applications.
SourceBolden Therapeutics states that it aims to improve the lives of people suffering from neurodegeneration and that its therapeutic approach is based on the belief that activating a key molecular pathway can promote the birth of new neurons in the adult brain. The company presents this neurogenesis-based mechanism as the basis for developing first-in-class treatments for central nervous system diseases including Alzheimer’s disease and ischemic stroke.
SourceBolden Therapeutics states that declining neurogenesis contributes to cognitive dysfunction, memory impairment, and reduced recovery after brain injury, and that increasing neurogenesis could improve outcomes in neurological disease. The company says neurogenesis has historically been difficult to manipulate therapeutically because sufficiently specific targets were lacking, and it presents its approach as targeting a novel, specific signaling pathway with first-in-class therapeutics, including exon-skipping antisense oligonucleotides.
SourceBolden Therapeutics states that increasing neurogenesis, the formation of new brain cells from endogenous neural stem cells, could improve outcomes across neurological diseases because neurogenesis is believed to be important for learning, memory, and recovery after brain injury, and its decline in disease states may contribute to cognitive dysfunction and memory impairment.
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