Plasmalogen Brain Function and Structure Research
exploratoryresearch program · high · Thu Mar 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Investigate whether blood plasmalogen measures are associated with cognition and brain imaging markers in older adults.
Cross-sectional analysis using a plasmalogen biosynthesis value calculated from five ratios of four glycerophospholipids, cognitive assessment, and 3T MRI white matter hyperintensity analysis.
2026 medRxiv study analyzed 298 older African American participants from MARS and Rush Clinical Core, with MRI data in 254 participants.
Higher PBV trended toward better global cognition and potentially lower white matter hyperintensities; authors stated larger and longitudinal studies are needed.
Plasmalogen biosynthesis value cognition biomarker research
exploratoryresearch program · high · Thu Jan 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate whether blood plasmalogen status is associated with cognition and brain white matter changes in older adults.
Cross-sectional cohort analysis using a plasmalogen biosynthesis value calculated from five ratios of four glycerophospholipids, with cognitive testing and 3T MRI white matter hyperintensity analysis.
2026 medRxiv study in older African American participants from MARS and the Rush Clinical Core reported associations between higher PBV, better global cognition, and potentially lower white matter hyperintensities.
Among 298 participants, higher PBV was suggestively associated with higher global cognition; among 254 with MRI data, higher PBV suggested lower white matter hyperintensities. Authors stated larger studies are needed.
Brain plasmalogen and Alzheimer's cognition research
exploratoryresearch program · high · Sat Jan 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Investigate whether brain ethanolamine plasmalogen levels are associated with cognition and dementia-related neuropathology.
Post-mortem comparative analysis of phosphatidylethanolamine and ethanolamine plasmalogen species, amyloid plaques, neurofibrillary tangles, flotillin-1, and cognition in inferior temporal cortex tissue from elderly subjects.
2022 Frontiers study reported that higher brain PUFA-plasmalogen levels, especially PL 18:0/22:6, were independently associated with better cognition.
High brain PL 18:0/22:6 was predictive of normal cognition and non-demented state, while low PL 18:0/22:6 and high tangles or flotillin were predictive of dementia.
Brain Ethanolamine Plasmalogen Cognition Research
exploratoryresearch program · medium
Assess associations between structurally specific brain ethanolamine plasmalogens, neuropathology, and cognition in elderly subjects.
Comparative post-mortem analysis of inferior temporal cortex tissue measuring phosphatidylethanolamines, ethanolamine plasmalogens, flotillin-1, amyloid plaques, neurofibrillary tangles, and cognition-related outcomes.
Post-mortem analysis of 100 elderly subjects from the Rush University Memory and Aging Project reported associations between higher DHA-containing plasmalogen levels and better cognition.
PL 18:0/22:6 was independently associated with cognition after adjustment for amyloid, tangles, PE, and flotillin-1; authors suggested maintenance or augmentation of brain DHA-plasmalogen levels warrants further investigation.
PC+
undisclosedconsumer product · medium
Provide targeted nutrition related to Prodrome Science's cellular membrane and lipid biology positioning.
Consumer supplement product category listed as PC+ with related formulations.
Listed for sale on the Prodrome site as a product category.
Plasmalogen and Lipid Biology Research Program
exploratoryresearch program · high
Investigate relationships between plasmalogens, cellular membranes, cognition, brain structure, neurodegeneration, and healthy aging.
Lipid and metabolomic research, blood plasmalogen measures, plasmalogen biosynthesis value calculations, brain imaging associations, and post-mortem comparative phospholipid analyses.
A 2026 medRxiv study reported associations between higher plasmalogen biosynthesis value and higher global cognition, with potential association with lower white matter hyperintensities in older African Americans.
Supplied publications report that higher plasmalogen biosynthesis value was suggestively associated with higher global cognition and potentially lower white matter hyperintensities; a 2022 post-mortem analysis found brain PL 18:0/22:6 independently associated with cognition and non-demented state.
PlasmalogenN3
undisclosedconsumer product · high
Support membrane lipid biology using a plasmalogen product positioned by Prodrome within its brain-health and cellular-membrane supplement offerings.
Consumer plasmalogen formulation listed in Prodrome's plasmalogen product line.
Listed for sale on Prodrome's public shop navigation.
Practitioner lipid biology education and protocols
undisclosedplatform · medium
Educate health professionals on lipid biology, plasmalogens, biomarker testing, and related protocols for cellular membrane health.
Practitioner education, protocols, and lipid biology content connected to Prodrome Science products and testing.
The company site describes practitioner education and protocols as part of its offering.
Prodrome BDMC
undisclosedconsumer product · high
Offer a curcuminoid product within Prodrome's nutrition product portfolio.
Consumer curcuminoid formulation listed as Prodrome BDMC.
Listed for sale on Prodrome's public shop navigation.
ProdromeGlia
undisclosedconsumer product · high
Support healthy cellular membranes through plasmalogen supplementation, aligned with Prodrome's plasmalogen and lipid-biology focus.
Consumer plasmalogen formulation listed under Prodrome's plasmalogen products.
Listed for sale on Prodrome's public shop navigation.
ProdromeGLIA-PC+
undisclosedconsumer product · high
Provide a PC+ nutrition product associated with Prodrome's glia-oriented supplement line and lipid-biology protocols.
Consumer PC+ formulation listed in Prodrome's product navigation.
Listed for sale on Prodrome's public shop navigation.
ProdromeNEURO-PC+
undisclosedconsumer product · high
Provide a PC+ nutrition product associated with Prodrome's neuro-oriented supplement line and lipid-biology protocols.
Consumer PC+ formulation listed in Prodrome's product navigation.
Listed for sale on Prodrome's public shop navigation.
Prodrome plasmalogen supplements
undisclosedconsumer product · high
Provide targeted nutrition/plasmalogen products intended to support healthy cellular membranes and brain health through lipid biology.
Consumer plasmalogen supplementation and related nutrition protocols.
Products are described as offered on the Prodrome Science site, alongside protocols and practitioner education.
Prodrome Professionals
undisclosedplatform · high
Provide health professionals with education, protocols, biomarker testing technologies, and practitioner access to Prodrome formulations.
Practitioner education and access platform including professional training, clinical education, protocols, biomarker testing access, and product access.
Company site invites professionals to apply for professional access and explore clinical education.
Prodrome Professional Training
undisclosedplatform · high
Educate health professionals on lipid biology, plasmalogens, biomarker testing technologies, and access to Prodrome formulations.
Practitioner education, professional access program, clinical education, protocols, and provider connection workflow.
Public site offers professional access, clinical education, and Prodrome Professional Training.
ProdromeScan
undisclosedbiomarker · high
Provide blood testing related to Prodrome's lipid biology and plasmalogen-focused health-professional protocols.
Blood test kit / biomarker testing technology referenced as ProdromeScan.
Listed on Prodrome's public site as a blood test kit and as part of practitioner biomarker testing access.
ProdromeScan blood testing
undisclosedbiomarker · high
Measure lipid and plasmalogen-related biomarkers to guide targeted nutrition and cellular membrane health protocols.
Blood testing for lipid/plasmalogen biomarker assessment.
ProdromeScan is listed on the company site as part of Prodrome Science's biomarker testing offering.
