Deep Learning Analysis of Altitude Effects on Aging
exploratoryresearch program · medium · Wed Jan 15 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Investigate how high altitude is associated with aging, age-related disease burden, mortality, life expectancy, facial biological aging, and cellular senescence markers.
Cross-sectional clinical study of 227 highland and 202 lowland dwellers in Tigray, Ethiopia, combined with mined risk exposure, disease burden, mortality, and life-expectancy datasets; biological aging was assessed from facial photographs and PBMC nuclear morphology using senescence predictors.
Published in GeroScience in 2025.
Higher-altitude Ethiopian regions showed lower risk exposure rates, reduced disease burden, increased life expectancy, and lower mortality; facial photographs suggested faster apparent aging with elevation, while PBMC nuclear morphology predictors suggested decreased DNA damage-induced senescence with increasing elevation.
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