p16INK4a Cellular Senescence Biomarker
exploratorybiomarker · medium · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Use p16INK4a expression as a biomarker of cellular senescence and physiological decline during aging or disease.
Measurement of p16INK4a expression, including in peripheral blood T lymphocytes, and association with clinical labs, quality-of-life measures, physical performance, frailty, or disease status.
2025 publication associated p16INK4a with therapy receipt and frailty status among adults with plasma cell disorders.
Studies reported associations between p16INK4a and physiological decline, clinical/QOL measures, accelerated aging in sickle cell disease, and frailty-related endpoints.
AKI-Sapere Cardiac Surgery Risk Prognostic
exploratorybiomarker · high · Mon Jan 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Predict cardiac surgery-associated acute kidney injury and related adverse cardiac or kidney outcomes before surgery.
Blood-based panel of senescence and immune biomarkers, including p16, p14, LAG3, CD244, CD28, and suPAR, measured pre-operatively and modeled for risk prediction.
GUARD-AKI clinical validation study listed to validate the AKI-Sapere prognostic in cardiac surgery patients; 2024 publication reported performance of a six-biomarker model.
A multivariate six-biomarker model predicted AKI, eGFR decline, and 30-day major adverse cardiac and kidney events, with reported negative predictive values of 86.6%, 93.5%, and 91.4%, respectively.
Taxane Chemotherapy-Induced Peripheral Neuropathy Risk Prediction Study
exploratoryresearch program · low · Wed May 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Discover patient- and procedure-based variables that identify early-stage breast cancer patients at risk of taxane chemotherapy-induced peripheral neuropathy.
Observational study of 350 patients undergoing taxane-based chemotherapy at UNC/Rex and UAB sites.
ClinicalTrials.gov record published for risk prediction of taxane chemotherapy-induced peripheral neuropathy.
SenesceTest Cardiac Surgery AKI Risk Study
exploratorybiomarker · high · Wed Jul 01 2015 00:00:00 GMT+0000 (Coordinated Universal Time)
Measure whether baseline senescence markers predict cardiac surgery-associated acute kidney injury after surgery.
Clinical study measuring senescence marker expression in blood using SenesceTest before cardiac surgery and associating results with post-surgical AKI.
ClinicalTrials.gov record published for use of aging biomarkers to predict adverse outcomes after cardiac surgery.
SenesceTest Contrast-Induced AKI Risk Study
exploratorybiomarker · high · Thu Jan 01 2015 00:00:00 GMT+0000 (Coordinated Universal Time)
Predict contrast-induced acute kidney injury after coronary angiography.
Clinical study measuring baseline senescence marker expression in blood using SenesceTest and associating results with CI-AKI after cardiac catheterization.
ClinicalTrials.gov record published for novel biomarkers for risk prediction of contrast-induced AKI post coronary angiography.
SenesceTest Kidney Transplant Function Study
exploratorybiomarker · high · Thu Jan 01 2015 00:00:00 GMT+0000 (Coordinated Universal Time)
Predict renal graft function after kidney transplantation using donor aging biomarkers.
Pilot clinical study measuring baseline SenesceTest aging biomarker expression in donor blood and comparing results with immediate and 1-year renal graft function.
ClinicalTrials.gov record published for biomarkers of aging as predictors of kidney transplant function.
SapereX Longevity Pathway
undisclosedconsumer product · high
Measure longevity-related biology, including immune resilience and cellular senescence, for individuals and concierge clinicians.
Biomarker testing performed through a CLIA-certified, CAP-accredited laboratory.
Listed as an active SapereX testing pathway in the supplied site analysis.
SapereX Performance Pathway
undisclosedconsumer product · high
Assess athletic performance, training, recovery, and burnout risk through cortisol rhythm signals.
Biomarker testing focused on cortisol rhythm.
Listed as an active SapereX testing pathway in the supplied site analysis.
