WormGazer Technology
preclinicalplatform · high · Wed Nov 08 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Rapidly measure C. elegans ageing and healthspan by monitoring movement, activity, speed, and distance travelled as functional ageing endpoints.
Automated, non-invasive imaging of multiple C. elegans populations in Petri dishes using WormGazer technology; movement endpoints are used as healthspan readouts.
A 2024 GeroScience publication reported that 7 days of WormGazer imaging was sufficient to measure dose-dependent efficacy of sulfamethoxazole to slow ageing, compared with 40 days for a parallel lifespan experiment.
Most functional decline in C. elegans occurred during the first week of adulthood; continuous movement analysis detected interventions that slow ageing and revealed potential negative effects on health such as slower early-adult movement in age-1(hx546) mutants.
ADORA2B/ador-1 Hypoxic Healthspan Adaptation Program
preclinicalresearch program · medium
Investigate whether the ADORA2B ortholog ador-1 is required for mild hypoxia-induced healthspan extension and multi-system transcriptional adaptation in C. elegans.
Wild-type and ador-1 knockout C. elegans were exposed to low-dose cobalt chloride as a mild hypoxia model; movement, speed, lifespan metrics, 3' RNA-seq, and GSEA were used to assess healthspan and transcriptional response.
A 2026 Free Radical Biology & Medicine publication reported ADORA2B/ador-1 requirement for coordinated transcriptional adaptation associated with hypoxia-induced healthspan extension.
Mild hypoxia extended healthspan in wild-type C. elegans by increasing sustained locomotor activity and distance travelled; benefits were attenuated in ador-1 mutants, which had reduced baseline healthspan and a blunted transcriptional response.
EU Healthy Ageing and Longevity Coordination and Support Programme Proposal
exploratoryresearch program · low
Establish an EU Coordination and Support Programme on Healthy Ageing and Longevity to integrate research, innovation, regulation, and capacity-building across Member States.
Policy and research coordination proposal focused on healthy ageing and longevity research support in Europe.
A 2026 Mechanisms of Ageing and Development publication called for creation of the EU programme.
The publication argues that accelerating population ageing, multimorbidity, and healthcare costs require coordinated EU-level support for healthy ageing and longevity research.
Pseudomonas aeruginosa In Vivo Infection and Biofilm Model
preclinicalplatform · medium
Develop in vivo C. elegans tools to study Pseudomonas aeruginosa infection and biofilm formation and support screening for antimicrobial strategies targeting infection, pathogenic biofilms, and virulence.
C. elegans infection assays using fluorescent P. aeruginosa reporters, in vivo imaging, GFP fluorescence, survival, and WormGazer automated movement tracking for healthspan endpoints.
A 2024 Frontiers in Cellular and Infection Microbiology publication described new tools for monitoring P. aeruginosa infection and biofilms in vivo in C. elegans.
Fluorescent P. aeruginosa reporters visualized tissue infection; timing of infection corresponded with health endpoint decline; an RhlR mutant showed reduced biofilm formation, tissue invasion, and negative impact on healthspan and survival, supporting RhlR as a potential antimicrobial target.
Timut Pepper Extract Longevity Program
preclinicalconsumer product · medium
Evaluate whether Timut pepper extract can promote lifespan, mobility, and extracellular matrix maintenance in ageing C. elegans as a candidate nutritional or supplement intervention for healthspan enhancement.
C. elegans lifespan and healthspan assays measuring lifespan, activity, speed, distance moved, and collagen expression after Timut pepper extract exposure.
A 2024 Nutrients publication reported lifespan- and healthspan-promoting effects of Timut pepper extract in C. elegans.
Timut pepper extract extended C. elegans lifespan at different maintenance temperatures, increased the proportion of active nematodes in early adulthood, enhanced speed and distance moved during ageing, and slowed age-dependent decline of collagen expression.
VivoScan Platform
undisclosedplatform · high
Provide whole-organism high-throughput screening at scale for customised C. elegans studies across ageing, neurodegeneration, toxicity, gut health, muscle health, cognition, disease modelling, and related service areas.
C. elegans whole-organism screening using automated imaging and high-throughput assay workflows.
Listed on the company site as Magnitude Biosciences' high-throughput whole-organism screening platform.
