Immune Training Is a Subroute
Tissue-resident innate immune training fits as a narrow route inside tissue immune setpoint modulation, but the edge still needs anchor evidence before anyone treats it as therapy.
These are not two ideas sitting side by side. Tissue immune setpoint modulation is the wider route; training tissue-resident innate immunity is one narrow route inside it.
What we know: the parent idea is to pull tissue-local cytokine and innate immune signaling back toward a working baseline: TNF, IL-6, IL-1beta, JAK-STAT, NF-kappaB, NLRP3, Treg expansion.
The child route: local immunomodulatory cues train macrophages, microglia, neutrophils, or NK cells to clear chronic dysfunction better. No cell replacement. No DNA editing.
Strong: the link is logical. Training is a specific case of setting local immune thresholds and responsiveness.
Thin: no anchor quote is stored. So this is a high-confidence map, not a proven therapy.
Next: attach source evidence, split targets by tissue, and test the ugly question: does clearance improve without drifting into chronic inflammation?
The selected edge has high conceptual confidence and clean taxonomy value, while the missing anchor quote forces an honest distinction between a useful route map and actual evidence.