Movement increases transdermal drug absorption

This proposed hypothesis asks whether early movement after a healing graft can speed skin-delivered drug absorption enough to hinder brain or kidney recovery. A patch creates a drug depot, a store that releases medicine over time. Movement can warm skin and increase perfusion, the blood flow through tissue; the model proposes that this produces brief drug peak despite an identical prescribed dose. Testing requires synchronized drug concentrations, skin monitoring, and measures of brain and kidney recovery. Harm following post-movement peaks, mainly in people using relevant patches, would support the mechanism. Harm with stable exposure or without a relevant patch would weaken it. Timing or formulation changes could then be tested for retaining movement's mechanical benefit while avoiding peaks.