C-1NDIoptogenetics, chemistry, AI
0-100 chain-logic scale · 15 dimensions · scored on public evidence
Advance novel small molecule therapeutics for age-related diseases.
Synthetic biology, chemistry, optogenetics, and AI are used to probe disease biology and explore chemical space.
Company states it is advancing a pipeline of novel small molecule therapeutics for age-related diseases.
Understand how dynamic Wnt signaling frequencies influence downstream pathway activation and cell fate decisions during development.
Optogenetic control of Wnt signaling in HEK293T cells and H9 human embryonic stem cells, with biochemical and hidden-variable modeling.
2026 eLife publication "Anti-resonance in developmental signaling regulates cell fate decisions."
Identified anti-resonant Wnt frequencies that minimize pathway response and dramatically reduce mesoderm differentiation in human gastrulation-related cell fate experiments.
Predict teratogenicity and human gastrulation failure modes to accelerate safer therapeutic discovery.
Failure Analysis and Trajectory Evaluation via Mechanistic-AI Prediction integrates high-throughput perturbations of human 2D gastruloids, quantitative phenotypic mapping, predictive deep learning, and mechanistic morphogen modeling.
Nature Communications publication in 2026 describing FATE-MAP and its application to over 2000 drug-treated human 2D gastruloids.
Mapped a phenotypic morphospace separating canonical patterning from failure modes, flagged two clinical molecules as potential teratogens, and identified cell density and SOX2 stability as orthogonal morphospace axes.
Discover modulators of the integrated stress response that could support therapeutic discovery in age-related disease biology.
Optogenetics-enabled discovery platform combining cellular pathway control with chemistry and AI-enabled small molecule discovery.
Publication listed on the company site: "Optogenetics-enabled discovery of integrated stress response modulators" in 2025.
Determine how reliably cells transmit information from Wnt signals to gene expression and identify optimal signal-encoding strategies.
Optogenetic control of canonical Wnt signaling with analysis of discrete versus continuous signal encodings and decoding maps.
2026 publication "Optimizing information transmission in optogenetic Wnt signaling."
Found that information capacity beyond 1 bit is reachable through discrete encoding using no Wnt, a short Wnt pulse, or sustained Wnt signaling; optimal encoding changes as effective noise decreases.
Clarify how aging-associated p16Ink4a-positive hepatocytes drive liver fibrosis and identify therapeutic intervention points.
CCl4-induced hepatitis model, selective elimination of p16Ink4a-positive hepatocytes, single-cell transcriptomic analysis, and LIFR pathway inhibition experiments.
2026 publication describing p16Ink4a-positive hepatocytes as drivers of liver fibrosis through LIFR family pathway activation.
Selective elimination of p16Ink4a-positive hepatocytes ameliorated CCl4-induced liver fibrosis; LIFR inhibition rescued fibrogenic phenotypes induced by secreted factors from senescent hepatocytes.