Integrated Biosciences

optogenetics, chemistry, AI

discoverydiscoveringsmall molecule

integratedbiosciences.com·Redwood City, California, United States·$17M total funding

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-1NDI

Summary · Eternal Search editorial

Integrated Biosciences optogenetics, chemistry, AI

Integrated Biosciences is advancing a pipeline of novel small molecule therapeutics for age-related diseases. Its platform combines synthetic biology, chemistry, and AI to probe disease biology and explore chemical space. The company states its science is built on pioneering work from scientific co-founder Prof. Jim Collins at MIT.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite39

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Integrated Biosciences — Early mechanism · Lower middle. Derived deterministically from 6 extracted project(s). Most-advanced status: preclinical. Band: early_mechanism. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webintegratedbiosciences.com

HQRedwood City, California, United States

Publications

36 on file

012026Nitroxoline-O-protected derivatives inhibit MetAP2 and activate ATF4 through mTORC1 to inhibit cancer cell growth.Bioorganic & medicinal chemistry letters→022026Optimizing information transmission in optogenetic Wnt signaling.Physical review research→032026FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling—→042026p16Ink4a-Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany)→052026FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modelingNature Communications→062026Anti-resonance in developmental signaling regulates cell fate decisions.eLife→072025Optogenetics-enabled discovery of integrated stress response modulators—→082025An explainable deep learning platform for molecular discovery.Nature protocols→092025Establishing the Asia & Pacific Bioinformatics Joint Congress: a historic milestone in regional bioinformatics collaboration.Briefings in bioinformatics→102025A generative deep learning approach to de novo antibiotic design.Cell→112025Optogenetics-enabled discovery of integrated stress response modulators.Cell→122025Infrared thermography unveiled the variation of brown adipose tissue thermogenesis among East Asian adults.Physiological reports→132025iNaturalist data suggests a recent northward expansion of the upside-down jellyfish, Cassiopea.The Science of the total environment→142025Functional diversity of the Osiris gene family in the brown planthopper.Crop health→152025Anti-resonance in developmental signaling regulates cell fate decisions.bioRxiv : the preprint server for biology→162025Genetic and phenotypic insights into Cyberlindnera jadinii as a promising yeast for industrial biotechnology.G3 (Bethesda, Md.)→172025A fungal transcription factor converts a beneficial root endophyte into an anthracnose leaf pathogen.Current biology : CB→182025Building Community Research Capacity to Address Cardiovascular Health Disparities.American journal of public health→192025Advances in induced anhydrobiosis for cell and gamete storage.Trends in biotechnology→202025Histone Modification-Dependent Transcriptional Regulation of Defence Genes in Early Response of Arabidopsis to Spodoptera litura Attack.Plant, cell & environment→212024Identification of gene isoforms and their switching events between male and female embryos of the parthenogenetic crustacean Daphnia magna.Scientific reports→222024Deep generative design of RNA aptamers using structural predictions.Nature computational science→232024Strongyloides questions-a research agenda for the future.Philosophical transactions of the Royal Society of London. Series B, Biological sciences→242024The roles of habitat isolation, landscape connectivity and host community in tick-borne pathogen ecology.Royal Society open science→252024Discovery of a structural class of antibiotics with explainable deep learning.Nature→262024Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans.International journal of obesity (2005)→272024Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations.Journal of physiological anthropology→282023Atg15 is a vacuolar phospholipase that disintegrates organelle membranes.Cell reports→292023Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinomaScience Advances→302020Measurement of 1α hydroxycorticosterone in the Japanese banded houndshark, Triakis scyllium, following exposure to a series of stressors.General and comparative endocrinology→312009Poster presentations.Surgical and radiologic anatomy : SRA→322008Neuropeptide Receptor Transcriptome Reveals Unidentified Neuroendocrine PathwaysPLoS ONE→332008Identification of cis-Acting Elements Repressing Blue Opsin Expression in Zebrafish UV Cones and Pineal CellsJournal of Biological Chemistry→342004Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA ClonesPLoS Biology→352001Wobble modification defect in tRNA disturbs codon–anticodon interaction in a mitochondrial diseaseThe EMBO Journal→362001Identification and Characterization of Mammalian Mitochondrial tRNA nucleotidyltransferasesJournal of Biological Chemistry→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Integrated Biosciences

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.