Altos Labs

cell rejuvenation, cellular rejuvenation programming

reprogrammingepigenetic reprogramming

altoslabs.com·2600 Bridge Parkway, Redwood City, CA 94065·Founded 2022·$3.0B total funding

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-DQLJ

Summary · Eternal Search editorial

Altos Labs cell rejuvenation, cellular rejuvenation programming

Altos Labs focuses on restoring cell health and resilience through cell rejuvenation. Its stated goal is to translate the biology of cell rejuvenation into medicine for disease, injury, and disabilities that occur throughout life. The company describes a multidisciplinary workplace built around translating breakthrough science into breakthrough medicine.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite31

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Altos Labs — Far from goals · Lower middle. Derived deterministically from 4 extracted project(s). Most-advanced status: undisclosed. Band: far. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webaltoslabs.com

HQ2600 Bridge Parkway, Redwood City, CA 94065

Founded2022

Publications

80 on file

012026Unmet need for multiuse phacoemulsification machine products: multisociety position paper.Journal of cataract and refractive surgery→022026Prevalence of GSTM1 and GSTT1 null polymorphisms in an admixed healthy Venezuelan population: implications for pharmacogenetic baselines.Frontiers in genetics→032026Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans.Proceedings of the National Academy of Sciences of the United States of America→042026Ageing and remyelination failure in people with multiple sclerosis.Brain : a journal of neurology→052026Progerin-induced nuclear envelope remodeling is shaped by cell division and NUP153.Journal of cell science→062026Multimodal Artificial Intelligence for Cardiac Amyloidosis Diagnosis: Integrating Echocardiography With Clinical and Laboratory Data for Improved Detection.Circulation. Cardiovascular imaging→072026Toward actionable interventions in human aging (12th ARDD meeting, 2025).Aging→082026Comparing Multislice Projections of MD Simulations with CryoEM Exposes Structural Prediction Errors.bioRxiv : the preprint server for biology→092026Senescence dynamics define therapeutic windows for Duchenne muscular dystrophy in DBA/2-mdx mice.Skeletal muscle→102026Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response.Science (New York, N.Y.)→112026Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodelingNature Aging→122026Mesenchymal drift: A convergent framework for the hallmarks of aging.Cell→132026Progerin-Induced Nuclear Envelope Remodeling is Shaped by Cell Division and NUP153bioRxiv (Cold Spring Harbor Laboratory)→142026Restoring the FOXO1 geroprotective pathway via seno-resistant mesenchymal progenitor cells alleviates primate epididymal aging.Protein & cell→152026Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.medRxiv : the preprint server for health sciences→162026Comparing multislice projections of MD simulations with cryo-EM exposes structural prediction errors.Biophysical journal→172026A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy.Developmental cell→182026Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates.Cell metabolism→192026The hologenome in brain health and disease.Neuron→202026Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.Aging→212026Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage.Nature communications→222026Methods of muscle atrophy analysis at the single-nucleus level.Mechanisms of ageing and development→232026Short-Range Order and LixTM4-x Probability Maps for Disordered Rocksalt Cathodes.Small (Weinheim an der Bergstrasse, Germany)→242026Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort.Nature aging→252026A targeted metabolomic method to detect epigenetically relevant metabolites.Molecular metabolism→262026Social Determinants and Outbreak Dynamics of the 2025 Measles Epidemic in Mexico: A Nationwide Analysis of Linked Surveillance Data.Viruses→272026Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study.Aging cell→282026Anti-aging strategies and ex vivo organ rejuvenation.Cell stem cell→292026Patient Out-of-Pocket Costs and Healthcare Utilization Related to Mastectomy vs Breast Conservation: A Claims-Based Study.Journal of surgical oncology→302026Past, present and future perspectives on the science of aging.Nature aging→312026Establishment and Performance Evaluation of a Multiplexed TET2-APOBEC-Mediated cfDNA Methylation Detection Workflow Using qPCR and dPCR Readouts.Journal of personalized medicine→322026Functional landscape of non-canonical open reading frames in coordinating cell fate.Molecular cell→332026Assessment of the family system in patients with medically unexplained symptoms.General hospital psychiatry→342026Postprandial response of leptin and adiponectin to standardized high-carbohydrate and high-fat meals in adults: A cross-sectional study.PloS one→352026Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC v2.0 arrays.Mechanisms of ageing and development→362026Mechanosensor YAP orchestrates human neural rosette morphogenesis via TEAD4-LEF1 transcriptional nexus.Science China. Life sciences→372026Trans-arterial gemcitabine micro perfusion of locally advanced pancreatic cancer enabled by coil plus glue embolization of a pancreaticoduodenal branch.Radiology case reports→382026Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging.Developmental cell→392026Mitochondrial Transplantation in the Eye: A Review and Evaluation of Surgical Approaches.bioRxiv : the preprint server for biology→402026Reprogramming the GRHL2-CDK19 axis by gene therapy alleviates prostate aging.Nature aging→412026International consensuses and guidelines on multifocal intraocular lenses (IOLs) by the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO).Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)→422025Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's diseaseAlzheimer s & Dementia→432025Epigenetic clocks of biological aging and risk of incident mild cognitive impairment and dementia: the Women's Health Initiative Memory Study.medRxiv : the preprint server for health sciences→442025Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age.Nature metabolism→452025The Role of Artificial Intelligence in Advancing Clinical Care in Cardiovascular Nursing.The Journal of cardiovascular nursing→462025Alteration of gut microbial ecology by the direct activation of the brain: Inverse gut-microbiome-brain dynamics.iScience→472025Development and Validation of a Multimodal Artificial Intelligence-derived Digital Pathology-based Biomarker Predicting Metastasis Among Patients with Biochemical Recurrence After Radical Prostatectomy in NRG/RTOG Trials.European urology→482025The central clock drives metabolic rhythms in muscle stem cells.Cell reports→492025Vitamin C conveys geroprotection on primate ovaries.Cell stem cell→502025A Roadmap for the Future of Systems Biology in Cancer Research.Cancer research→512025Nuclear-lamin-guided plastic positioning and folding of the human genome.Cell reports→522025Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signatureNature Communications→532025Allosteric Disordering of eIF2B Regulates the Integrated Stress ResponsebioRxiv (Cold Spring Harbor Laboratory)→542025Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health OutcomesAdvanced Science→552025Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networksGenome biology→562025Biomarkers of Aging– <scp>NIA</scp> Joint Symposium 2024: New Insights Into Aging BiomarkersAging Cell→572025Invigorating discovery and clinical translation of aging biomarkersNature Aging→582025Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1.Nature communications→592025Organelle homeostasis requires ESCRTs.Current opinion in cell biology→602025Harmonizing the Generation and Pre-publication Stewardship of FAIR bioimage data.ArXiv→612025Open problems in ageing science: a roadmap for biogerontology.GeroScience→622025Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1.bioRxiv : the preprint server for biology→632024Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelinationNature Communications→642024De novo-designed minibinders expand the synthetic biology sensing repertoireeLife→652024Membrane biophysics in the cryo-electron microscopeBiophysical Journal→662024Cognitive rejuvenation in old rats by hippocampal OSKM gene therapyGeroScience→672024Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged miceCell Reports Medicine→682024Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.Cancer discovery→692024Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespanbioRxiv (Cold Spring Harbor Laboratory)→702024Exploring the Interplay between Cellular Senescence, Immunity, and Fibrosing Interstitial Lung Diseases: Challenges and OpportunitiesInternational Journal of Molecular Sciences→712024Product-stabilized filamentation by human glutamine synthetase allosterically tunes activityBiophysical Journal→722024Primordial germ cell DNA demethylation and development require DNA translesion synthesisNature Communications→732024Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis PigmentosaInvestigative Ophthalmology & Visual Science→742023Targeting Mitochondria to Control Ageing and SenescencePharmaceutics→752023Human senescent fibroblasts trigger progressive lung fibrosis in miceAging→762023Epigenetic dynamics during capacitation of naïve human pluripotent stem cellsScience Advances→772023Brominated lipid probes expose structural asymmetries in constricted membranesNature Structural & Molecular Biology→782023A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone diseaseNature Communications→792022Structure and functionality of a multimeric human COQ7:COQ9 complex.Molecular cell→802016In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming—→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Altos Labs

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.