Cellular rejuvenation therapeutics discovery platform
undisclosedplatform · high · Wed Jan 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Discover and develop medicines that restore cell health and resilience through cellular rejuvenation, with the stated goal of reversing disease, injury, and disabilities.
Cellular rejuvenation approach combining academic-style discovery with industry translation; the supplied material does not identify a specific therapeutic candidate or clinical indication.
Altos Labs launched with $3B fully committed to pursue cellular rejuvenation programming and medicine development.
Cellular rejuvenation programming
exploratoryplatform · medium
Restore cell health and resilience through cell rejuvenation, with the long-term aim of reversing disease, injury, and life-related disabilities.
Multidisciplinary cell rejuvenation and cellular rejuvenation programming research platform; supplied evidence cites early experiments in which cells regain resistance to stressors associated with disease.
Altos Labs publicly describes its work as translating rejuvenation biology into breakthrough medicine; no specific pipeline candidate or clinical milestone is disclosed in the supplied material.
Early experiments are described as showing that cells can regain resistance to stressors that give rise to disease. Filtered foundational publications include in vivo partial reprogramming ameliorating age-associated hallmarks and induction of pluripotent stem cells by defined factors.
Computational biology and generative modeling platform
exploratoryplatform · medium
Use machine learning, multi-scale generative models, and internally generated data to support discovery of cellular rejuvenation biology and medicine development.
Computational platform involving machine learning, multi-scale generative models, internally generated data, and an Institute of Computation.
Altos operates an Institute of Computation led by Hana El-Samad and describes computation, machine learning, and multi-scale generative models as part of its work.
Partial cellular reprogramming research program
exploratoryresearch program · medium
Investigate whether partial reprogramming can ameliorate age-associated hallmarks and support cellular rejuvenation without full dedifferentiation.
Partial reprogramming based on defined reprogramming factors, supported by foundational iPSC and in vivo partial reprogramming publications listed in the supplied material.
Altos lists foundational publications on induced pluripotent stem cells and in vivo amelioration of age-associated hallmarks by partial reprogramming.
The supplied publication metadata identifies a 2016 Cell paper titled 'In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming' and a 2006 Cell paper on induction of pluripotent stem cells by defined factors.
