Tune Therapeutics

epigenetic editing, genetic tuning, TEMPO

editinggene editing

tunetx.com·Seattle, Washington, United States; Raleigh-Durham, North Carolina, United States·$40M total funding

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-3VDJ

Summary · Eternal Search editorial

Tune Therapeutics epigenetic editing, genetic tuning, TEMPO

Tune Therapeutics was founded on advances in gene regulation and describes its technology as enabling control over gene activity. Its proprietary TEMPO platform is intended to dial gene expression up or down without cutting or altering DNA. The company says this approach could address rare genetic disorders as well as common, chronic, and age-related diseases.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite12

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Tune Therapeutics — Translational · Bottom quartile. Derived deterministically from 2 extracted project(s). Most-advanced status: phase 1. Band: translational. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webtunetx.com

HQSeattle, Washington, United States; Raleigh-Durham, North Carolina, United States

Publications

80 on file

012026Mechanically Adaptive Viscoelastic Grain-Boundary Regulation in Blade-Coated Tin-Lead Perovskites.ACS applied materials & interfaces→022026Controlling PEDOT:PSS electropolymerization for label-free optical recording of bioelectric potentials.Journal of materials chemistry. B→032026Local Electronic Modulation in Pillararene-Based Donor-Acceptor Conjugated Polymers for Selective Photocatalytic Oxygen Reduction.Angewandte Chemie (International ed. in English)→042026Migration of co-cultured endothelial and smooth muscle cells on material surfaces.Regenerative biomaterials→052026Synergizing Mass Transfer and Exciton Dissociation in Nanoscale COFs for Efficient H2O2 Photosynthesis.Angewandte Chemie (International ed. in English)→062026Tensile Lattice Strain via Sulfur Vacancies Activates Interlayer Charge Transfer in ZnIn2S4 for Superior Photocatalytic U(VI) Removal.Inorganic chemistry→072026Ag-Doping-Mediated Interlayer Coordination Engineering: Enabling Thermoelectric ZT = 1 in TMDs-Derived Narrow-Gap Semiconductor CuCrTi2Se6.Journal of the American Chemical Society→082026Programming-voltage-induced interface charge redistribution for a Lu2O3/Nb:SrTiO3 deep-ultraviolet photodetector: Achieving reconfigurable logic gates at zero bias.Journal of colloid and interface science→092026Hydrogen-Bond Network Modulation of Cellulose Nanocrystal Films by Sodium Lipoate for Closed-Loop Recycling.Biomacromolecules→102026Operando Strain Modulation Amplifies Asymmetric C─C Coupling for CO-to-Acetate Transformation.Small (Weinheim an der Bergstrasse, Germany)→112026Janus-enhanced magnetic modulation under strain engineering and carrier doping in Fe3GaTe2 monolayers.Nanoscale→122026Regulating ammonia decomposition activity by engineering interface structure of ultrafine ruthenium nanoparticles anchored on cerium dioxide with different morphologies.Journal of colloid and interface science→132026Impact of afucosylation strategy on antibody function: a comparative study of glycoengineered anti-CD20 antibodies Obinutuzumab and Obinutuzumab beta.mAbs→142026Reconstructing 12-lead ECG from 3-lead ECG using variational autoencoder to improve cardiac disease detection of wearable ECG devices.PLOS digital health→152026Modulating energy band structure and energy transfer pathways in CAU-10 series MOFs via ligand engineering to enhance photocatalytic oxidase-like activity for multimodal phytate detection.Biosensors & bioelectronics→162026Fine-Tuning the Coordination Structure and Identifying Pt1-Ov-Ce as the Active Site for Selective Hydrogenations over Pt1/CeO2 Single-Atom Catalysts.Journal of the American Chemical Society→172026Multi-strategy quantum-inspired dung beetle optimizer for kernel extreme learning machine in slope safety factor prediction.Scientific reports→182026Microenvironment Engineering Vinylene-Linked Covalent Organic Frameworks for Highly Efficient CO2 Photoreduction.Journal of the American Chemical Society→192026Precision Selenium Doping Unlocks Palladium Nanocluster for Efficient Chemoselective Hydrogenations.Journal of the American Chemical Society→202026Integrin-Targeted Delivery of Redox Homeostasis Regulating Lanthanide-Based Composite Nanoplatform for Deep Self-Enhanced Photodynamic/H2S Gas Synergistic Therapy via 1530 nm Activation.Advanced healthcare materials→212026Optimizing Machine Learning with SSA and PSO for Anchor Bolt-Grout Bond Strength Prediction.Materials (Basel, Switzerland)→222026HighFold-MeD2: An Enhanced Boltz-2 Model for Accurate Structure Prediction of N-Methylated and d-Amino Acid Cyclic Peptides.Journal of chemical information and modeling→232026Molecular and hormonal regulation of plant responses to waterlogging stress: From fundamental mechanisms to potential strategies for engineering crop tolerance.Plant communications→242026Enolase 1: A paradigm of metabolic enzyme moonlighting in tumorigenesis (Review).International journal of oncology→252026Manipulating Charge-Mechanical Coupling to Achieve Superior Ductility and High Thermoelectric Properties in Layered Bismuth Telluride.Small (Weinheim an der Bergstrasse, Germany)→262026GhUGT84A1 underlying a novel locus qOC-A03-1 regulates cottonseed oil content revealed by integrated deep resequencing and QTL mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik→272026The bHLH transcription factor IBL1 fine-tunes growth and development via restraining cell elongation/expansion in Arabidopsis.Plant physiology→282026Ni-site local magnetism regulated via intrinsic exchange in NiFeCo electrocatalysts.Journal of colloid and interface science→292026Achiral Guest-Modulated Circularly Polarized Luminescence of Chiral Macrocycles by Host-Guest Encapsulation.Journal of the American Chemical Society→302026Transcription factor shielding yields a highly specific and sensitive whole-cell biosensor for Pb2+ detection.Biosensors & bioelectronics→312026Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through conformational gate control.Protein science : a publication of the Protein Society→322026Ferroptosis regulator families in metabolic diseases: Molecular networks and therapeutic opportunities.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)→332026Vortex-enhanced bone regeneration: gyroid gradient scaffolds tune permeability for hemodynamic-accelerated osseointegration.Journal of materials chemistry. B→342026Parallel Diffusion Solver via Residual Dirichlet Policy Optimization.IEEE transactions on pattern analysis and machine intelligence→352026Epigenetic regulation of cuproptosis in cancer: mechanisms, microenvironment, and therapeutic implications.Frontiers in cell and developmental biology→362026The mutational landscape of STING-induced immunity.Nature→372026CNS-Obsidian: A Neurosurgical Vision-Language Model Built From Scientific Publications.Neurosurgery→382026Suppression of Chain Walking by Heteroatom in 2,3-Bis(imino)butane-Nickel Precatalysts for Ethylene Polymerization.Inorganic chemistry→392026Interstitial Copper Doping and Thermally Activated Rattling in La3- xTe4 for Enhanced Thermoelectric Performance.Angewandte Chemie (International ed. in English)→402026Targeting the Light-Harvesting Complex I Gene Lhca4 Confers Saline-Alkali Tolerance in Rice Without Yield Penalty.Plant, cell & environment→412026Approaching Zero Voltage Attenuation of Lithium-Rich Cathodes through Electrochemical Relaxation.Advanced materials (Deerfield Beach, Fla.)→422026Theory Guided Fine-Tune of Strain Effects in Pt Ternary Alloy via Rare Earth Templating: Achieving High Performance PEMFCs Catalysts.Advanced materials (Deerfield Beach, Fla.)→432026Multi-Scale Water Modulation for Regulating Water Reactivity and Suppressing Nanoscale Zero-Valent Iron (nZVI) Corrosion.Small (Weinheim an der Bergstrasse, Germany)→442026Mitochondrial OXPHOS integrates immunometabolic cascade for bone regeneration via coupled ATP production and ROS homeostasis.Redox biology→452026Size-dependent ruthenium/ceria nanozymes synchronize catalytic ROS scavenging and electrostatic mtDNA sequestration for periodontitis therapy.Journal of nanobiotechnology→462026Neuronal UBE3A loss engages a TNF-driven neuron-to-microglia axis that promotes synapse remodeling.bioRxiv : the preprint server for biology→472026Preparation, Interaction Mechanism and Application of Functional Ionic Liquid-Mediated Protein Imprinting Technique.Polymers→482026Solvent reverse osmosis beyond size exclusion in two-dimensional nanochannel membranes.Nature communications→492026The ATG14: multi-layer autophagy control and an emerging therapeutic target in cancer.Apoptosis : an international journal on programmed cell death→502026Mitochondria-associated endoplasmic reticulum membrane (MAM): roles in innate immunity dysregulation.Cell communication and signaling : CCS→512026LlR3MYB-mediated flavonoid biosynthesis confers cold stress tolerance in Lilium lancifolium through the LlDREB-LlCHS2 regulatory cascade.Horticulture research→522026The master regulators of delayed-type drug hypersensitivity reactions.Current opinion in allergy and clinical immunology→532026Matching the Coupling of Valence Electrons in the Oxide Interface to Perturb the Magnetic Order Enhancing Oxygen Reduction in Zinc-Air Batteries.Angewandte Chemie (International ed. in English)→542026Regulation of bubble evolution dynamics by surfactants during water electrolysis.Journal of colloid and interface science→552026Towards better red emitters for bioimaging: Innovations in rhodamine and cyanine chemistry.Current opinion in chemical biology→562026Immunopharmacology of GPR35: Context-driven signaling and functional plasticity in host defense.Biochemical pharmacology→572026Anion Chemistry: Structure, Electrochemistry and Stability of NASICON Cathodes.Nano-micro letters→582026A chemically-aware validation framework for benchmarking large language models in materials synthesis planning.Journal of cheminformatics→592026Cortical activity increases in speech motor areas as a function of the subjective loudness of inner speech.Frontiers in human neuroscience→602026Bridging Microscopic Interfacial Water and Macroscopic Wettability for Enhanced Hydrogen Evolution Reaction.Small (Weinheim an der Bergstrasse, Germany)→612026Nf2 orchestrates β-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity.Proceedings of the National Academy of Sciences of the United States of America→622026ARIADNE: A Perception-Reasoning Synergy Framework for Trustworthy Coronary Angiography Analysis.Journal of imaging informatics in medicine→632026Constructing Intermediate Encapsulation on Ru/CeO2 Nanocatalysts to Enhance Ammonia Synthesis.Small (Weinheim an der Bergstrasse, Germany)→642026Organic Intercalation Enables Controllable Single-Atom Coordination for Efficient H2O2 Electrosynthesis.Angewandte Chemie (International ed. in English)→652026Surface modification of ferrous sulfide nanosheets for in-situ remediation of cadmium-contaminated groundwater.Journal of environmental sciences (China)→662026Fractional-Order PI-Like Trajectory Tracking Control of Four-Wheel Skid Steering Small Autonomous Ground Vehicles.IEEE transactions on cybernetics→672026The ZAT7-OTU11-DOA9-CYS13 module enhances salt resistance via suppressing NPF2.4-mediated chloride uptake in Arabidopsis.Plant communications→682026Near Infrared Dyes Based on Diradicaloids: Molecular Design, Photophysical Properties and Bioapplications.ACS applied materials & interfaces→692026Morphological Control of Self-Assembled Monolayers on Multiple-Solvent-Doped PEDOT:PSS Electrodes for Ultrathin Flexible Organic Optoelectronics.Small (Weinheim an der Bergstrasse, Germany)→702026Energy-Efficient Electrocatalytic Semi-Hydrogenation of Alkynols by Synergistic Ni-Fe Pairs and Ni Clusters on N-Doped Carbon.Angewandte Chemie (International ed. in English)→712026Mapping and engineering the human cell-cell interactome.Nature biotechnology→722026N/Si-Doped Nonbenzenoid Buckybowls with Tunable Configurations and Optoelectronic Properties.Journal of the American Chemical Society→732026Evolutionary constraints impose multiple checkpoints that block mammalian sensory hair cell regeneration.Frontiers in cell and developmental biology→742026Tuning *OH Oxidativity via a Cu-Co(OH)2 Cocatalyst on a Hematite Photoanode for Selective Cyclohexanone Oxidation.Journal of the American Chemical Society→752026A critical review of gold(I) complexes as anticancer agents: from canonical mechanisms to immune activation.Bioorganic chemistry→762026Quantum-Enhanced Dark Matter Search Using Cat States.Physical review letters→772026TaSRO1 recruits the histone deacetylase TaHIS1 to repress TaABI5 and fine-tune ABA signaling during seed dormancy release in wheat.The Plant cell→782026Configuration-Dependent Interactions between Ferroelectric and Ferroelastic Domains in PZT Thin Films Revealed by In Situ TEM.ACS applied materials & interfaces→792026Automated synthesis of InSb quantum dots with improved batch-to-batch reproducibility via kinetically matched co-reduction.Nature communications→802026Concentration-Responsive Gd-DOTA Nanomicelles via Chain-Length Engineering for Transporter-Independent Hepatobiliary Magnetic Resonance Imaging.Langmuir : the ACS journal of surfaces and colloids→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Tune Therapeutics

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.