NeuroBio

T14 peptide, biomarker diagnostics, neurodegeneration therapeutics

modulatingbiologic

neuro-bio.com·Oxford, United Kingdom·Founded 2013·Seed

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-LM4P

Summary · Eternal Search editorial

NeuroBio T14 peptide, biomarker diagnostics, neurodegeneration therapeutics

Neuro-Bio is a privately owned biotech focused on neurodegenerative diseases, especially Alzheimer's disease. The company has discovered T14, a novel molecule described as toxic in the adult brain and a key driver of neurodegeneration. It is developing a pre-symptomatic biomarker, diagnostic approaches, and drug candidates based on this mechanism.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite24

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

NeuroBio — Early mechanism · Bottom quartile. Derived deterministically from 7 extracted project(s). Most-advanced status: preclinical. Band: early_mechanism. Modifiers: +5 depth (3 programs at preclinical).…

Source: Deterministic

At a glance

Webneuro-bio.com

HQOxford, United Kingdom

Founded2013

StageSeed

Publications

77 on file

012026Sex and dose-dependent effects of cannabidiol on cocaine consumption in mice.Translational psychiatry→022026Evaluating the Efficacy of Monoclonal Antibodies Against a Bioactive Peptide Involved in Alzheimer's Disease: A Methodological Approach.Methods and protocols→032026Therapeutic antagonism of a key toxin driving Alzheimer's disease: Comparison of a peptide variant and small molecule.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie→042026Prenatal-lactational alcohol exposure induces sex-specific CX3CL1/CX3CR1 dysregulation linked to neuroendocrine imbalance and cardiovascular risk.Brain, behavior, and immunity→052025Widespread Changes in the Immunoreactivity of Bioactive Peptide T14 After Manipulating the Activity of Cortical Projection Neurons.International journal of molecular sciences→062025Prenatal alcohol exposure dysregulates the expression of clock genes and alters rhythmic behaviour in mice.Open biology→072025A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice.Neurobiology of aging→082025Irregular light schedules disrupt daily rhythms and dysregulate genes involved in neuroplasticity, motivation, and stress responses.Pharmacology, biochemistry, and behavior→092025Chronic circadian disruption in adolescent mice impairs hippocampal memory disrupting gene expression oscillations.Scientific reports→102024Rodent Models of Alzheimer's Disease: Past Misconceptions and Future Prospects.International journal of molecular sciences→112024Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli.Open biology→122024A Novel Peptide Driving Neurodegeneration Appears Exclusively Linked to the α7 Nicotinic Acetylcholine Receptor.Molecular neurobiology→132024Evidence for a novel neuronal mechanism driving Alzheimer’s disease, upstream of amyloid—→142024A Novel 14mer Peptide Inhibits Autophagic Flux via Selective Activation of the mTORC1 Signalling Pathway: Implications for Alzheimer's Disease.International journal of molecular sciences→152024Oxidative Stress Triggers a Pivotal Peptide Linked to Alzheimer's Disease.International journal of molecular sciences→162024Evidence for a novel neuronal mechanism driving Alzheimer's disease, upstream of amyloid.Alzheimer's & dementia : the journal of the Alzheimer's Association→172023The role of PPAR-γ in memory deficits induced by prenatal and lactation alcohol exposure in mice.Molecular psychiatry→182023[Challenges and choices: translational acupuncture research spectrum-a proposal].Zhen ci yan jiu = Acupuncture research→192023Antagonism of a key peptide 'T14' driving neurodegeneration: Evaluation of a next generation therapeutic.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie→202023A novel peptide 'T14' reflects age and photo-aging in human skin.Aging→212023Antagonising a novel toxin "T14" in Alzheimer's disease: Comparison of receptor blocker versus antibody effects in vitro.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie→222022Effects of fast-acting antidepressant drugs on a postpartum depression mice model.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie→232022Bmal1-knockout mice exhibit reduced cocaine-seeking behaviour and cognitive impairments.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie→242022A novel process driving Alzheimer's disease validated in a mouse model: Therapeutic potential.Alzheimer's & dementia (New York, N. Y.)→252022Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation.Behavioural brain research→262022Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol.Progress in neuro-psychopharmacology & biological psychiatry→272022Characterization of a Bioactive Peptide T14 in the Human and Rodent Substantia Nigra: Implications for Neurodegenerative Disease.International journal of molecular sciences→282022CB1 receptor antagonist AM4113 reverts the effects of cannabidiol on cue and stress-induced reinstatement of cocaine-seeking behaviour in mice.Progress in neuro-psychopharmacology & biological psychiatry→292022When a trophic process turns toxic: Alzheimer's disease as an aberrant recapitulation of a developmental mechanism.The international journal of biochemistry & cell biology→302021Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring.The international journal of neuropsychopharmacology→312021Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression.Frontiers in pharmacology→322021Unraveling the molecular mechanisms involved in alcohol intake and withdrawal in adolescent mice exposed to alcohol during early life stages.Progress in neuro-psychopharmacology & biological psychiatry→332021Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression.Neuropharmacology→342021Cannabidiol attenuates cognitive deficits and neuroinflammation induced by early alcohol exposure in a mice model.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie→352021Maternal separation increases cocaine intake through a mechanism involving plasticity in glutamate signalling.Addiction biology→362021Cocaine-seeking behaviour is differentially expressed in male and female mice exposed to maternal separation and is associated with alterations in AMPA receptors subunits in the medial prefrontal cortex.Progress in neuro-psychopharmacology & biological psychiatry→372021Neuroinflammatory and behavioral susceptibility profile of mice exposed to social stress towards cocaine effects.Progress in neuro-psychopharmacology & biological psychiatry→382021Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice.Alzheimer's research & therapy→392021Modulation of recognition memory performance by light and its relationship with cortical EEG theta and gamma activities.Biochemical pharmacology→402020Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice.British journal of pharmacology→412020The Tryptophan System in Cocaine-Induced Depression.Journal of clinical medicine→422020Sex differences in the vulnerability to cocaine's addictive effects after early-life stress in mice.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology→432020The Pro-neurogenic Effects of Cannabidiol and Its Potential Therapeutic Implications in Psychiatric Disorders.Frontiers in behavioral neuroscience→442020Curcumin treatment attenuates alcohol-induced alterations in a mouse model of foetal alcohol spectrum disorders.Progress in neuro-psychopharmacology & biological psychiatry→452019Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain.Addiction biology→462019White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.Alzheimer's & dementia (New York, N. Y.)→472019Histone deacetylases inhibitor trichostatin A reverses anxiety-like symptoms and memory impairments induced by maternal binge alcohol drinking in mice.Journal of psychopharmacology (Oxford, England)→482019Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation.Journal of psychopharmacology (Oxford, England)→492019Progressive signaling changes in the olfactory nerve of patients with Alzheimer's disease.Neurobiology of aging→502019Neuroadaptive changes and behavioral effects after a sensitization regime of MDPV.Neuropharmacology→512018A Multidisciplinary Approach Reveals an Age-Dependent Expression of a Novel Bioactive Peptide, Already Involved in Neurodegeneration, in the Postnatal Rat Forebrain.Brain sciences→522018Altered brain functional connectivity and behaviour in a mouse model of maternal alcohol binge-drinking.Progress in neuro-psychopharmacology & biological psychiatry→532018An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices.Journal of visualized experiments : JoVE→542018Modulatory Effects of a Novel Cyclized Peptide in Reducing the Expression of Markers Linked to Alzheimer's Disease.Frontiers in neuroscience→552018[Effect of Manual Acupuncture Preconditioning on Behavior and Contents of Serum CGRP, SP, IL-1 β and TNF-α Levels in Migraine Rats].Zhen ci yan jiu = Acupuncture research→562018Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus.Neuropharmacology→572018Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology→582018Carbonic Anhydrase XII Inhibitors Overcome P-Glycoprotein-Mediated Resistance to Temozolomide in Glioblastoma.Molecular cancer therapeutics→592017Cognitive impairments associated with alterations in synaptic proteins induced by the genetic loss of adenosine A2A receptors in mice.Neuropharmacology→602017Optical imaging of the rat brain suggests a previously missing link between top-down and bottom-up nervous system function.Neurophotonics→612017Exposure of adolescent mice to 3,4-methylenedioxypyrovalerone increases the psychostimulant, rewarding and reinforcing effects of cocaine in adulthood.British journal of pharmacology→622017Maternal alcohol binge drinking induces persistent neuroinflammation associated with myelin damage and behavioural dysfunctions in offspring mice.Neuropharmacology→632017Tumor cell migration is inhibited by a novel therapeutic strategy antagonizing the alpha-7 receptor.Oncotarget→642016(II) Physiological profiling of an endogenous peptide in the basal forebrain: Age-related bioactivity and blockade with a novel modulator.Neuropharmacology→652016(I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains.Neuropharmacology→662016The Features and Functions of Neuronal Assemblies: Possible Dependency on Mechanisms beyond Synaptic Transmission.Frontiers in neural circuits→672016Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach.Histopathology→682015Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas?OncoTargets and therapy→692015The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment.International journal of oncology→702015SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy.Oncotarget→712014Stem cell niches in glioblastoma: a neuropathological view.BioMed research international→722013Promoter hypermethylation of the EMP3 gene in a series of 229 human gliomas.BioMed research international→732012MGMT hypermethylation and MDR system in glioblastoma cancer stem cells.Cancer genomics & proteomics→742012MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors.Journal of neuro-oncology→752011IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors.Journal of neuro-oncology→762011Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres.Journal of oncology→772011SOX2 expression and amplification in gliomas and glioma cell lines.Cancer genomics & proteomics→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

NeuroBio

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.