Shift Bioscience

cell rejuvenation, aging clocks, siRNA therapeutics

reprogrammingrna therapeutic

shiftbioscience.com·Cambridge (UK)·$16M total funding

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-IU8N

Summary · Eternal Search editorial

Shift Bioscience cell rejuvenation, aging clocks, siRNA therapeutics

Shift Bioscience targets the underlying cause of age-driven diseases: the aging cell. Its platform combines a novel aging clock, AC4, with a virtual cell model to discover cellular aging and rejuvenation targets. Its product program includes SB101, an anti-fibrotic siRNA therapeutic intended to reverse epigenetic aging clocks in multiple cell types, with initial opportunities in liver fibrosis.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite15

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Shift Bioscience — Early mechanism · Bottom quartile. Derived deterministically from 8 extracted project(s). Most-advanced status: preclinical. Band: early_mechanism. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webshiftbioscience.com

HQCambridge (UK)

Publications

80 on file

012026Platform shift in mental health support among undergraduates: from campus counselors to GenAI-based consultation.Frontiers in psychiatry→022026Severity-dependent alterations of functional network segregation and integration in tobacco use disorder.Progress in neuro-psychopharmacology & biological psychiatry→032026Betulinic acid regulates microglial polarization by inhibiting the phosphorylation of CB2 receptors thereby improving ischemic brain injury.Phytomedicine : international journal of phytotherapy and phytopharmacology→042026Molecular characterization and whole-genome sequencing-based genetic evolution of coxsackievirus A16 in Taiyuan City, 2023-2025.Archives of virology→052026Comparative safety assessment of measles-containing vaccination schedules in Jiangsu Province, China: A population-based pharmacovigilance study (2014-2024).Human vaccines & immunotherapeutics→062026A supramolecular MgTA@MnO₂ nanozyme platform supports human spinal cord organoid structural integration and locomotor recovery via microenvironmental reprogramming.Biomaterials advances→072026Amino-functionalized bimetallic MOF nanozyme via solvent-assisted ligand exchange for interference-free phenolic detection.Analytical methods : advancing methods and applications→082026Rewiring cell death and evading repair: Evolution of temozolomide and emerging strategies against resistant glioblastoma.European journal of medicinal chemistry→092026Improving Nitrogen Use Efficiency in Wheat: Integrating Agronomic, Genomics, and Remote Sensing for Sustainable Production.Plant, cell & environment→102026Conformational Transduction Amplification in a Biomimetic Polyelectrolyte for Ultrasensitive Imaging of Iron Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany)→112026Inflammation-associated brain functional network topological disruption in female nurses with SWSD: associations with symptoms and transcriptomics.Frontiers in immunology→122026Phase-tuned modulation during reward expectancy in human anterior insular cortex.Communications biology→132026The impacts and potential affecting mechanism of pile-driving noise on metabolism of the thick-shell mussel Mytilus coruscus.Environmental pollution (Barking, Essex : 1987)→142026Rational design of high-loading electrocatalytic electrodes: from static multiscale integration to dynamic intelligent systems.Chemical Society reviews→152026Hydrogen suppressed tumor growth during chronic intermittent hypoxia via modulating macrophage polarization.Scientific reports→162026Strong band bowing in BiOX (X = Cl, Br, I) due to halogen alloying.Physical chemistry chemical physics : PCCP→172026Integrated network toxicology and transcriptomics reveal NF-κB signaling as a key mediator of TDCPP-induced inflammatory responses in human microglia.Environment international→182026Defining neurovascular ecosystem states with single-cell multi-omics and machine learning: insights into cerebrovascular remodeling in the tumor context.Frontiers in cell and developmental biology→192026Manganese: biology, physiology and role in disease.Cell discovery→202026Discovery of fluoxakalner, a novel and preferential Kv7.2/7.3 channel opener for antinociception in mice.Bioorganic chemistry→212026Impact of table tennis participation on visual acuity and eye health in adolescents.Medicine→222026pH-dependent mechanism of hydrazine oxidation on hematite-based photoanode.Journal of colloid and interface science→232026Research on polarization-chiral sensing of arginine based on S-shaped and X-shaped terahertz metamaterials.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy→242026Integrated transcriptomic and metabolomic analysis of a mutant reveals the potential mechanism of endosperm content increase in sweet-waxy double recessive maize.BMC plant biology→252026Advances in precision synthesis and synergistic applications of Janus nanostructures.Advances in colloid and interface science→262026GhLBD18 triggers GhATG18a-dependent autophagy during somatic embryogenesis in cotton.Journal of advanced research→272026Leveraging Photothermal Effect in 1D Covalent Organic Frameworks for Efficient, Rapid, and Selective Gold Recovery.Angewandte Chemie (International ed. in English)→282026Seasonal water quality index prediction in Guilin karst water system: an explainable machine learning approach.Scientific reports→292026From blueprint to build: Metal ions in peripheral nerve development and engineering regeneration.Bioactive materials→302026Cinnamoyl-containing non-ribosomal peptides: discovery, bioactivity and biosynthesis.Natural product reports→312026Rutin attenuates liver fibrosis via the IRG1-itaconate-Nrf2 axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.]→322026Differential rumen responses in neonatal ruminants to volatile fatty acids, glucose, and physical stimulation: insights into the drivers of early rumen development.Journal of advanced research→332026Temperature governs resistance assembly and dissemination in the freshwater plastisphere.Environmental pollution (Barking, Essex : 1987)→342026Trabecular-Like Scaffold Dictates Osteogenesis via Fluid Shear Stress-Induced Metabolic Reprogramming through the CAV1-HIF-1α Axis.Research (Washington, D.C.)→352026Chrysin reprograms microglial metabolism and function via targeting SYK to alleviate the symptoms of Alzheimer's disease.Journal of ethnopharmacology→362026Nutritional dynamics and untargeted metabolomics reveal breed and lactation-dependent shifts in goat milk composition: from colostrum to mature milk.Food chemistry: X→372026Aridity-related differences in soil elemental ratios reshape microbial functional traits across global biomes.Nature communications→382026Outside-in foraminal access for cervical dumbbell tumors: a surgical paradigm shift with technical insights and clinical outcomes.Journal of neurosurgery. Spine→392026The association between shift work, occupational physical activity and cardiovascular-kidney-metabolic syndrome: a cohort study in China.Frontiers in public health→402026Trends and Disparities in CAR-T Therapy Utilization, Inpatient Mortality, Length of Stay, and Costs in the United States (2017-2022).Transplantation and cellular therapy→4120261-Dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide Interface Design  for Stable and Effective Perovskite Solar Cells.ChemSusChem→422026A membrane-anchored nanoscale zero-valent iron bio-interface enhances interspecies electron transfer in anaerobic membrane bioreactors.Bioresource technology→432026Mapping the Research Landscape on Postoperative Hypoxemia: A Bibliometric Analysis (1998 to 2024).Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses→442026Generative AI in physical education and health: a narrative review and conceptual framework for interdisciplinary thematic learning.Frontiers in public health→452026N-methyl-d-aspartate receptor subunits interacting with regulators mediate neuropathic pain: from mechanisms to therapy.Frontiers in neuroendocrinology→462026Precision Electronic Tuning of Gold Nanoclusters: A Generalizable Strategy for Enhanced Hydrogen Evolution Electrocatalysis via Platinum Doping.Inorganic chemistry→472026Integrative multi-omics analysis reveals a gut-liver axis signature of metabolic reprogramming associated with response to transarterial chemoembolization in hepatocellular carcinoma.BMC gastroenterology→482026HPV-specific innovations and controversies in therapeutic strategies for HPV-associated oropharyngeal carcinoma.Frontiers in immunology→492026ToxiSpecies: Task-Aware Meta-Learning for Cross-Species Modeling of Acute Chemical Toxicity under Distribution Shift.Journal of chemical information and modeling→502026Construction of psoralen - loaded targeted polymeric nanoparticles for enhanced anti - triple negative breast cancer efficacy via modulation of tumor associated macrophages in vitro.International journal of pharmaceutics→512026Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis.International journal of molecular medicine→522026Quercetin attenuates skin inflammation and fibrosis in systemic sclerosis by targeting the RELA/c-Jun axis to suppress th17 cell responses.Frontiers in immunology→532026Single-cell multiomic approaches define a gradual, spatially regulated epigenetic and transcriptional transition from embryonic to adult neural stem cells.Stem cell reports→542026The developmental shift in aperiodic activity and its link to the default mode network in attention-deficit hyperactivity disorder.Psychological medicine→552026Novel perspectives on PPARγ regulation: from SPPARMs to the emerging role of lncRNAs in metabolic disorders.International journal of obesity (2005)→562026Covalently bridged interface engineering for suppressing interfacial defects toward high-stability and low-voltage organic transistors and circuits.Science bulletin→572026Ischemia-Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions.MedComm→582026Association Between Shift Patterns and Occupational Stress and Perceived Professional Benefits Among Nurses: A Cross-Sectional Study.Journal of nursing management→592026Tandemly duplicated HmALS3 gene cluster mediates aluminum hyperaccumulation via a heteromeric transport complex in Hydrangea macrophylla.Journal of hazardous materials→602026APOE4 accelerates menopause-associated brain metabolic shift and disrupts bioenergetic adaptation.Frontiers in aging neuroscience→612026Single nucleus RNA sequencing reveals testosterone replacement therapy-associated multicellular remodelling of skeletal muscle in hypogonadal men with Klinefelter Syndrome.The Journal of clinical endocrinology and metabolism→622026Heat Stress and Kidney Injury in Taiwanese Farmers: Associations With Renal Artery Resistance and Urinary Acidification.American journal of kidney diseases : the official journal of the National Kidney Foundation→632026Beyond the 'second brain': the gut microbiota as a constitutive co-constructor of embodied cognitive network.Frontiers in neuroscience→642026Intra-arterial thrombolysis as adjunct to endovascular treatment in acute basilar artery occlusion.Journal of neurology→652026Associations Among the Gradient Refractive Index of the Lens, Axial Length, and Refractive State in the Developing Murine Eye.Investigative ophthalmology & visual science→662026Signatures of Protein Fold Switching in the Unfolded State.Biophysical journal→672026The EnvZ/OmpR two-component regulatory system regulates biofilm formation in Salmonella pullorum via interaction with the LuxS/AI-2 quorum sensing system and activation of the SoxR-AcrAB-TolC pathway.Frontiers in microbiology→682026Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work-Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany)→692026Determinants of Bird Richness in the Louzishan National Nature Reserve: Effects of Productivity and Habitat Heterogeneity Across Taxonomic and Functional Dimensions.Ecology and evolution→702026Dynamic-based representation inconsistency and implicit constraints for offline reinforcement learning.Neural networks : the official journal of the International Neural Network Society→712026Metabolic reprogramming of glutamine is associated with M2 macrophage polarization in allergic rhinitis.Frontiers in immunology→722026Delayed emission and pathway shift as drivers of N2O reduction in biological nitrogen removal with aniline exposure.Journal of environmental management→732026Hesperetin and Naringenin promote glucagon-like peptide-1 secretion from L-cell through activation of TGR5 and alleviated type 2 diabetes.Frontiers in pharmacology→742026Graph attention network-enhanced multi-agent reinforcement learning for dynamic interception task allocation in counter-drone defense.Scientific reports→752026Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation.PLoS computational biology→762026Elucidating the Potential Anti-asthmatic Mechanism of Aster tataricus by Combining Network Pharmacology with Experimental Validation in a Murine Model.Combinatorial chemistry & high throughput screening→772026Research trends and hot topics of radiation-induced pulmonary fibrosis: a bibliometric analysis and visualization study from 2015 to 2025.Journal of thoracic disease→782026Zeta potential: An efficient and cost-effective alternative for investigating cell-surface interactions.Methods (San Diego, Calif.)→792026Analysis and comparison of the trends in burden of congenital musculoskeletal and limb anomalies in China and worldwide from 1990 to 2021.Medicine→802026Salvianolic Acid B Protects Against Contrast-Induced Acute Kidney Injury by Attenuating Ferroptosis via the SIRT1/Nrf2 Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Shift Bioscience

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.