AI-powered virtual cell technology
exploratoryplatform · high · Tue Feb 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Discover and model cellular aging and rejuvenation targets for therapeutics development.
Virtual cell model combined with the AC4 aging clock; includes genetic perturbation modeling and metric calibration for AI virtual cells.
North American facilities established to expand capabilities; improved metric calibration framework for robust genetic perturbation modeling using AI virtual cells published in 2025.
The supplied material states that Shift published an improved metric calibration framework for robust genetic perturbation modeling using AI virtual cells, but does not provide detailed performance results.
AI Virtual Cell Technology
exploratoryplatform · high · Tue Feb 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Model genetic perturbations and support discovery of cellular aging and rejuvenation targets for therapeutics development.
AI-powered virtual cell model with metric calibration framework for robust genetic perturbation modeling.
Shift Bioscience published an improved metric calibration framework for robust genetic perturbation modeling using AI Virtual Cells; it also established North American facilities to expand capabilities of this technology.
The supplied material identifies publication of an improved metric calibration framework but does not provide quantitative results.
AC4 aging clock
exploratorybiomarker · high
Measure cellular aging and support discovery of cellular aging and rejuvenation targets.
Aging-clock assay used together with a virtual cell model to identify targets for cell rejuvenation therapies.
Described as part of Shift Bioscience's platform for discovering cellular aging and rejuvenation targets.
AC4 Aging Clock
exploratorybiomarker · medium
Measure cellular aging and support discovery of rejuvenation targets.
Aging clock used with a virtual cell model to identify cellular aging and rejuvenation targets.
Described as part of Shift Bioscience's platform for discovering cellular aging and rejuvenation targets.
AC4 aging clock and AI virtual cell platform
exploratoryplatform · high
Discover cellular aging and rejuvenation targets by modeling aging cells and genetic perturbations.
Combines the AC4 aging clock with an AI virtual cell model for robust genetic perturbation modeling and target discovery.
2025 publication/announcement of an improved metric calibration framework for robust genetic perturbation modeling using AI virtual cells.
The supplied material states that Shift published an improved metric calibration framework for robust genetic perturbation modeling using AI virtual cells, but provides no quantitative results.
AI Virtual Cell Model Platform
exploratoryplatform · high
Discover cellular aging and rejuvenation targets and improve genetic perturbation modeling.
AI virtual cell model combined with metric calibration for genetic perturbation modeling.
Publication of an improved metric calibration framework for robust genetic perturbation modeling using AI Virtual Cells.
The supplied material identifies a 2025 company publication on improved metric calibration for AI Virtual Cells, but does not provide detailed results.
SB000
undisclosedother · low
Undisclosed pipeline program in Shift Bioscience's rejuvenation therapeutics pipeline.
Not disclosed in the supplied material.
Listed in the company's pipeline.
SB101
preclinicaldrug program · high
Develop an anti-fibrotic therapeutic for liver fibrosis and other fibrotic diseases by targeting aging-cell biology.
siRNA therapeutic program identified from Shift Bioscience's cell rejuvenation platform.
Listed as the company's lead product with opportunities in liver fibrosis and other fibrotic diseases.
