TNF Pharmaceuticals (was MyMD)

biotech pharmaceuticals, MYMD-1, Supera-CBD

modulatingsmall molecule

tnfpharma.com·Baltimore, Maryland, United States·Public

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-MGFM

Summary · Eternal Search editorial

TNF Pharmaceuticals (was MyMD) biotech pharmaceuticals, MYMD-1, Supera-CBD

TNF Pharmaceuticals, formerly MyMD Pharmaceuticals, presents itself as a biotech pharmaceutical company. The site lists pipeline programs MYMD-1 and Supera-CBD, along with research and clinical trials sections. A September 2, 2025 press release says TNF Pharmaceuticals entered a licensing agreement with LightSolver for computing technology in cryptocurrency and blockchain applications.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite19

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

TNF Pharmaceuticals (was MyMD) — Translational · Bottom quartile. Derived deterministically from 3 extracted project(s). Most-advanced status: phase 2. Band: translational. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webtnfpharma.com

HQBaltimore, Maryland, United States

StagePublic

Publications

80 on file

012026Traumatic hemothorax activates complement, stimulates proinflammatory cytokine release, and primes neutrophils for local inflammatory reactive oxygen species production.The journal of trauma and acute care surgery→022026SKIN AS A POTENTIAL ENTRY POINT FOR SARS-COV-2.bioRxiv : the preprint server for biology→032026Recreational physical activity and biomarkers of breast cancer risk in a cohort of adolescent girls.Breast cancer research : BCR→042026Categorization of chronic pain subtypes and contributing biomarkers in heart failure.European journal of cardiovascular nursing→052026A radiopharmaceutical enhances CAR T cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling.Cell reports. Medicine→062026How pro-inflammatory diets influence perioperative outcomes.Pain management→072026Gingivitis Pathogenesis Involves Upregulation of Glycolysis and Citric Acid Cycle Activity Mediated by Bacterial Virulence Factors.International journal of molecular sciences→082026Next-generation precision medicine for pain.Molecular psychiatry→092026Immune Checkpoint Therapy Drives Maturation of a Cellular Neighborhood Nucleated by T Cell-APC Triads Enabling Spatially Compartmentalized Tumor Immunity.bioRxiv : the preprint server for biology→102026Biomarkers of Cellular Senescence and their Association with Frailty, Clinical Outcomes, and Survival in Multiple Myeloma.Research square→112026Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children.Allergy→122026Re-shaping the immune response to influenza vaccination in a host with immune memory from influenza infection.NPJ vaccines→132026MAIT cell responses to S. aureus and sensitivity to HlgAB are modulated by activation and tissue-dependent virulence effects.bioRxiv : the preprint server for biology→142026Concomitant liver steatosis in chronic HBV infection is linked to a distinct cytokine profile and reduced viral load.The Journal of infectious diseases→152025The effect of milk fat globule membrane phospholipid supplementation on cognitive function in older adults with subjective memory complaints-a randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition→162025Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology.Journal of neuroinflammation→172025Re-shaping the immune response to influenza vaccination in a host with immune memory from influenza.bioRxiv : the preprint server for biology→182025Temporal profiling of haptoglobin and cytokines in feedlot cattle with bovine respiratory disease.Frontiers in veterinary science→192025IL-13 Modulates Antiviral Effector and Proinflammatory Pathways in Rhinovirus-Infected Pediatric Bronchial Epithelium.bioRxiv : the preprint server for biology→202025TNF-α and IFN-γ differentially regulate AML cell susceptibility to CD70-antibody-mediated cytotoxicity.Journal for immunotherapy of cancer→212025Clinical response and corresponding blood transcriptome pathways before and after treatment of hereditary angioedema prodromes compared to active swelling attacks.The Journal of allergy and clinical immunology→222025Major Depressive Disorder and Serum Inflammatory Biomarkers as Predictors of Reward-Processing Dysfunction in an American Indian Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging→232025Viral replication and interferon responses in bronchial epithelia is enhanced by Th17 cells.bioRxiv : the preprint server for biology→242025Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates.Autophagy→252025ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling.iScience→262025Dynamic single cell transcriptomics defines kidney FGF23/KL bioactivity and novel segment-specific inflammatory targets.Kidney international→272025HDAC inhibitors engage MITF and the disease-associated microglia signature to enhance amyloid β uptake.Brain, behavior, and immunity→282025MetE: a promising protective antigen for tuberculosis vaccine development.Frontiers in immunology→292025Lung-Brain Axis-Generated Inflammatory Biomarkers in Traumatic Brain Injury and Acute Respiratory Distress Syndrome: Role of Mechanical Ventilation/Stress.Advances in biomarker sciences and technology→302024TNF Signaling Deficiency Promotes UVB-Induced Melanocyte Stem Cell Activation and Migration.The Journal of investigative dermatology→312024Defective proviruses significantly impact viral transcription and immune activation in men and women with HIV-1 subtype C in rural South Africa.Frontiers in immunology→322024Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets.bioRxiv : the preprint server for biology→332024Use of methotrexate and TNF inhibitors in patients with rheumatoid arthritis-associated interstitial lung disease: a survey of rheumatologists.Clinical rheumatology→342024Cellular heterogeneity in TNF/TNFR1 signalling: live cell imaging of cell fate decisions in single cells.Cell death & disease→352024Solar urticaria involves rapid mast cell STAT3 activation and neutrophil recruitment, with FcεRI as an upstream regulator.The Journal of allergy and clinical immunology→362024Exploring the efficacy of Transcutaneous Auricular Vagus nerve stimulation (taVNS) in modulating local and systemic inflammation in experimental models of colitis.Bioelectronic medicine→372024Development of Influenza-Specific CD4 T Cell-Mediated Immunity in Children Following Inactivated Influenza Vaccination.Journal of the Pediatric Infectious Diseases Society→382024Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor.Oncoimmunology→392024The effector program of human CD8 T cells supports tissue remodeling.The Journal of experimental medicine→402024TGFβ1-driven SMAD2/3 phosphorylation and myofibroblast emergence are fully dependent on the TGFβ1 pre-activation of MAPKs and controlled by maternal leucine zipper kinase.Cellular signalling→412024Therapeutic TNF Inhibitors Exhibit Differential Levels of Efficacy in Accelerating Cutaneous Wound Healing.JID innovations : skin science from molecules to population health→422024Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease.International journal of molecular sciences→432023Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation→442023Prospective Subunit Nanovaccine against Mycobacterium tuberculosis Infection─Cubosome Lipid Nanocarriers of Cord Factor, Trehalose 6,6' Dimycolate.ACS applied materials & interfaces→452023Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques.Cell host & microbe→462023The 2023 Impact of Inflammatory Bowel Disease in Canada: Special Populations-IBD in Seniors.Journal of the Canadian Association of Gastroenterology→472023Risks of Melanoma and Nonmelanoma Skin Cancers Pre- and Post-Inflammatory Bowel Disease Diagnosis.Inflammatory bowel diseases→482023Multifaceted roles of TAX1BP1 in autophagy.Autophagy→492023A Synthetic Formula Amino Acid Diet Leads to Microbiome Dysbiosis, Reduced Colon Length, Inflammation, and Altered Locomotor Activity in C57BL/6J Mice.Microorganisms→502023Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo.Biomolecules→512023Single-cell profiling identifies ACE+ granuloma macrophages as a nonpermissive niche for intracellular bacteria during persistent Salmonella infection.Science advances→522023Safety and immunogenicity of Multimeric-001 (M-001) followed by seasonal quadrivalent inactivated influenza vaccine in young adults - A randomized clinical trial.Vaccine→532023IV BCG Vaccination and Aerosol BCG Revaccination Induce Mycobacteria-Responsive γδ T Cells Associated with Protective Efficacy against M. tb Challenge.Vaccines→542023A Purine Derivative Containing an Organoselenium Group Protects Against Memory Impairment, Sensitivity to Nociception, Oxidative Damage, and Neuroinflammation in a Mouse Model of Alzheimer's Disease.Molecular neurobiology→552022Safety and Feasibility Assessment of Repetitive Vascular Occlusion Stimulus (RVOS) Application to Multi-Organ Failure Critically Ill Patients: A Pilot Randomised Controlled Trial.Journal of clinical medicine→562022Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.Annals of the rheumatic diseases→572022Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia.Current biology : CB→582022Acute vaping in a golden Syrian hamster causes inflammatory response transcriptomic changes.American journal of physiology. Lung cellular and molecular physiology→592022Vitamin E Decreases Cytotoxicity and Mitigates Inflammatory and Oxidative Stress Responses in a Ferret Organotypic Brain Slice Model of Neonatal Hypoxia-Ischemia.Developmental neuroscience→602022Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling.Nature communications→612022Lenabasum Reduces Porphyromonas gingivalis-Driven Inflammation.Inflammation→622022Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.The Journal of experimental medicine→632022Earlier Anti-TNF Initiation Leads to Long-term Lower Health Care Utilization in Crohn's Disease but Not in Ulcerative Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association→642022Epithelial-Fibroblast Crosstalk Protects against Acidosis-Induced Inflammatory and Fibrotic Alterations.Biomedicines→652022Prospective self- and informant-personality associations with inflammation, health behaviors, and health indicators.Health psychology : official journal of the Division of Health Psychology, American Psychological Association→662022Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction.EBioMedicine→672022A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population.PloS one→682022Murine RAW Macrophages Are a Suitable Model to Study the CD3 Signaling in Myeloid Cells.Cells→692022Immune Activation in Primary Human Immunodeficiency Virus: Influence of Duration of Infection, Treatment, and Substance Use.Open forum infectious diseases→702022Increased expression of pro-inflammatory cytokines at the fetal-maternal interface in bovine pregnancies produced by cloning.American journal of reproductive immunology (New York, N.Y. : 1989)→712022Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex.International journal of molecular sciences→722021Biomarkers for prediction of skeletal disease progression in mucopolysaccharidosis type I.JIMD reports→732021Erratum. Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes. Diabetes 2012;61:2134-2145.Diabetes→742021A Novel Strategy to Identify Haematology Patients at High Risk of Developing Aspergillosis.Frontiers in immunology→752021Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer.Frontiers in pharmacology→762021Relationship between inflammation and metabolic regulation of energy expenditure by GLP-1 in critically ill children.Clinical nutrition (Edinburgh, Scotland)→772021Detection of bovine inflammatory cytokines IL-1β, IL-6, and TNF-α with a multiplex electrochemiluminescent assay platform.Veterinary immunology and immunopathology→782021Continued 5ASA use after initiation of anti-TNF or immunomodulator confers no benefit in IBD: a population-based study.Alimentary pharmacology & therapeutics→792021Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study.PLoS medicine→802021Syncytiotrophoblast Extracellular Vesicles From Late-Onset Preeclampsia Placentae Suppress Pro-Inflammatory Immune Response in THP-1 Macrophages.Frontiers in immunology→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

TNF Pharmaceuticals (was MyMD)

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.