Fate Therapeutics

iPSC platform, cell programming, cellular immunotherapy

replacementreplacingcell therapy

fatetherapeutics.com·San Diego, California, United States·Public

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-5FX4

Summary · Eternal Search editorial

Fate Therapeutics iPSC platform, cell programming, cellular immunotherapy

Fate Therapeutics is a clinical-stage biopharmaceutical company developing a first-in-class pipeline of programmed off-the-shelf cellular immunotherapies. Its approach uses engineered human induced pluripotent stem cells to create clonal master iPSC lines for renewable cell manufacture. The company is advancing multiplexed-engineered T cell and natural killer cell product candidates for autoimmune diseases and cancer.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite10

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Fate Therapeutics — Translational · Bottom quartile. Derived deterministically from 20 extracted project(s). Most-advanced status: phase 2. Band: translational. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webfatetherapeutics.com

HQSan Diego, California, United States

StagePublic

Publications

80 on file

012026Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs.Advanced science (Weinheim, Baden-Wurttemberg, Germany)→022026Dissolved organic matter enhances sunlight-induced transformation of tire rubber antioxidant 6PPD to 6PPD-quinone in aquatic environments.Water research→032026Aerobic soil bacteria adapt to hypoxia by hybridizing fermentation with carbon storage.Proceedings of the National Academy of Sciences of the United States of America→042026Biodegradation of cyano liquid crystal monomers by an aerobic enrichment culture: Key degraders and interspecies synergistic mechanisms.Water research→052026The multilayered identity of B cell memory.Cellular & molecular immunology→062026Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs.Stem cell reports→072026Transformation and Defluorination of Fluorotelomer Carboxylic Acids by Pseudomonas sp. strain 273.Environmental science & technology→082026Deletion of vitamin D receptor with calcium sensing receptor in keratinocytes promotes epidermal tumorigenesis by limiting dna repair and oxidative stress response genes.The Journal of steroid biochemistry and molecular biology→092026FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling.Nature communications→102026METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs.Cardiovascular research→112026Exploring Sacred Moments in Japanese Healthcare.Journal of general internal medicine→122026Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss.Molecular neurodegeneration→132026Remodelling and the fate of bone grafts in shoulder instability surgery.Journal of experimental orthopaedics→142026Investigation of a GPC1-targeted and LIFU-responsive nanoplatform with ADV effect for visualized chemo-sonodynamic therapy against pancreatic ductal adenocarcinoma.Journal of cancer research and clinical oncology→152026Coordinated inhibition of SOX9 and cell cycle progression by microRNA-200 restricts sebaceous gland fate specification.bioRxiv : the preprint server for biology→162026A robust cis-regulatory network ensures Otx2 expression during retinal development.Development (Cambridge, England)→172026Preliminary Phase 1 Results of a MICA/B-targeted CAR T cell Designed to Overcome Solid Tumor Escape Mechanisms and Avoid the Requirement for Conditioning Chemotherapy—→182026FT839: A Multi-Antigen Targeting Off-the-Shelf Dual-CAR T Cell for the Treatment of Pathogenic B and T Cells in Autoimmune Diseases—→192026The Treg-cell death axis in lung cancer: implications for immune evasion and novel therapeutic strategies.Molecular cancer→202026Bispecific BAFF-R/BCMA CAR T cells control growth of heterogeneous plasma cells in multiple myeloma.Molecular therapy : the journal of the American Society of Gene Therapy→212026Redefining the Cerebral Ischemic Core-Penumbra-Oligemia Continuum.Stroke→222026Effect of taxonomical distance and scriptaid on iSCNT embryo development in suidaeScientific Reports→232026tRNA modifications in cancer: from molecular mechanisms to clinical translation.Biomarker research→242026Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization.Bone research→252026CLIC-dependent internalization of caveolin-1 to lysosomal vacuoles in response to osmotic regulation.Cell reports→262026Quantification of cell viability by automated analysis of live cell imaging.Methods in cell biology→272026Safety and Efficacy of an Off-the-Shelf Anti-CD19 CAR T-Cell Therapy With Reduced Conditioning in SLE: A Phase 1 Study Supporting Same-Day Discharge—→282026From guardians to traitors: molecular mechanisms of tumor-induced T cell betrayal.Molecular cancer→292026Ether lipids influence cancer cell fate by modulating iron uptake.Nature communications→302025Understanding the interplay between pH and charges for theranostic nanomaterials.Nanoscale→312025Hematopoietic stem cells undergo bidirectional fate transitions in vivo.bioRxiv : the preprint server for biology→322025Deep soil contributions to global nitrogen budgets.Nature communications→332025Oncogene Silencing via ecDNA Micronucleation.bioRxiv : the preprint server for biology→342025Inflammatory, transcriptomic, and cell fate responses underlying the mammalian transmission of avian influenza viruses.Journal of virology→352025Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted.Nature→362025Phase Separation in Chromatin Organization and Human DiseasesInternational Journal of Molecular Sciences→372025The fate of atenolol in wastewater treatment plants of representative densely urban agglomerations in China.Journal of environmental quality→382025Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming.Cell metabolism→392025Organic pollutants leaching from tire waste: Ecotoxicity implications for aquatic species.Aquatic toxicology (Amsterdam, Netherlands)→402025Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.American journal of human genetics→412025Charge matters: how flanking substrate charge modulates O-glycan Core elongation.Glycobiology→422025Multiplexing light-inducible recombinases to control cell fate, Boolean logic, and cell patterning in mammalian cells.Science advances→432025OP0032 Treatment of Refractory Systemic Lupus Erythematosus with Off-the-Shelf iPSC-derived Anti-CD19 CAR T-cell TherapyAnnals of the Rheumatic Diseases→442025Ether lipids influence cancer cell fate by modulating iron uptake.bioRxiv : the preprint server for biology→

452025Treatment of Refractory SLE with Off-the-Shelf iPSC-derived Anti-CD19 CAR T-cell Therapy—→

462025Metabolic Studies of Nandrolone Decanoate in Castrated Horses After Intramuscular Administration.Drug testing and analysis→472025Fate, transport, and plant uptake of ricinine in soils amended with castor cake organic fertilizer.Journal of hazardous materials→482025Tumor suppressor protein p53 governs human trophoblast lineage development.Cell reports→492025EmbSAM: cell boundary localization and Segment Anything Model for fast images of developing embryos.Communications biology→502025Isotopically resolved fate and processes of nitrogen in a constructed wetland treating domestic effluent.The Science of the total environment→

512025Longitudinal Analysis of B cell Remodeling in Systemic Lupus Erythematosus Following iPSC-derived CAR T-cell Therapy—→

522025Environmental fate and behavior studies of a polymeric PFAS, polytetrafluoroethylene (PTFE) - results and application to risk assessment.Chemosphere→532025Development of Next Generation Multi-Antigen Targeting Off-the Shelf CAR T-Cells for Conditioning-Free Treatment of B-Cell Lymphoma—→542025Ribosome biogenesis and homeostasis: in the front line to cope with cellular stress.Biochimie→552025Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss.bioRxiv : the preprint server for biology→562025Author Correction: An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.Nature communications→572025Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry.Nature communications→582025Uptake of per- and polyfluorinated alkyl substances by dry farmed oats following the agricultural application of biosolids and compost.Environmental science. Processes & impacts→592025Signaling induced biophysical disruption of repressed chromatin domains drives immune cell fate.bioRxiv : the preprint server for biology→602025An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.Nature communications→612025Cancer stem cells: mitochondria signalling pathway and strategies for therapeutic interventions.Molecular biology reports→622025Regulation of the mechanoresponsive Neat1 and PSPC1 by substrate stiffness in TGF-β1-induced renal progenitor cell fate.Journal of biomedical science→632025Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors.The EMBO journal→642025Determination of trunk neural crest cell fate and susceptibility to splicing perturbation by the DLC1-SF3B1-PHF5A splicing complex.Nature communications→652025Functional defects in FOXG1 variants predict the severity of brain anomalies in FOXG1 syndrome.Molecular psychiatry→662025In Vivo Metabolic Studies of 2-Hydroxyethyl Salicylate in Horses.Drug testing and analysis→672025Adrenergic signaling coordinates distant and local responses to amputation in axolotl.Cell→682025The next frontier in lung development and regeneration research: harnessing iPSC models to illuminate notch signaling pathways.Frontiers in cell and developmental biology→692025CETN3 deficiency induces microcephaly by disrupting neural stem/progenitor cell fate through impaired centrosome assembly and RNA splicing.EMBO molecular medicine→702025Inflammasome-resistant IPSC-derived myeloid-derived suppressor cells ameliorate xenogeneic graft-versus-host disease.Blood→712025<scp>FT538</scp>, <scp>iPSC</scp>‐derived <scp>NK</scp> cells, enhance <scp>AML</scp> cell killing when combined with chemotherapyJournal of Cellular and Molecular Medicine→722025A novel CD3ε fusion receptor allows T cell engager use in TCR-less allogeneic CAR T cells to improve activity and prevent antigen escape.Molecular therapy : the journal of the American Society of Gene Therapy→732025iPSC-derived trimodal T cells engineered with CAR, TCR, and hnCD16 modalities can overcome antigen escape in heterogeneous tumorsCell Reports Medicine→742025Off-the-shelf induced pluripotent stem-cell-derived natural killer-cell therapy in relapsed or refractory B-cell lymphoma: a multicentre, open-label, phase 1 study.The Lancet. Haematology→752025Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis.bioRxiv : the preprint server for biology→762025Spatial variation in the mutation rate within the plant shoot apical meristem.Proceedings of the National Academy of Sciences of the United States of America→772025Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis.Cell reports→782025Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics.PNAS nexus→792025Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis.Stem cell reports→802025POS0060 NEXT-GENERATION OFF-THE-SHELF CAR T CELLS: A NOVEL PLATFORM TO ENABLE COMPREHENSIVE ELIMINATION OF ABERRANT EFFECTOR CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES IN THE ABSENCE OF CONDITIONING CHEMOTHERAPYAnnals of the Rheumatic Diseases→

Loading

Loading section...

0-100 chain-logic scale · 15 dimensions · scored on public evidence

Fate Therapeutics

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.