NuSirt

sirtuin activation, drug combinations, cardiometabolic health

modulatingsmall molecule

nusirt.com·Knoxville, Tennessee, United States·$2M total funding

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-YB4U

Summary · Eternal Search editorial

NuSirt sirtuin activation, drug combinations, cardiometabolic health

NuSirt Sciences focuses on combining leucine with established natural compounds and pharmaceuticals to synergistically activate the sirtuin pathway. Its products target chronic cardiometabolic diseases associated with overnutrition and aging, including MAFLD, MASH, obesity, type 2 diabetes, pre-diabetes, and hypertension. The company is developing TRIPLN, a combination of L-leucine, metformin, and sildenafil, and produces LEUSIX, a leucine and vitamin B6 dietary supplement.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite28

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

NuSirt — Translational · Lower middle. Derived deterministically from 4 extracted project(s). Most-advanced status: phase 2. Band: translational. Modifiers: +5 modality breadth (3 modalities…

Source: Deterministic

At a glance

Webnusirt.com

HQKnoxville, Tennessee, United States

Publications

22 on file

012025Leucine, pyridoxine and resveratrol supplementation alter metabolic parameters in ponies with equine metabolic syndrome.Equine veterinary journal→022020Leucine and Sildenafil Combination Therapy Reduces Body Weight and Metformin Enhances the Effect at Low Dose: A Randomized Controlled Trial.American journal of therapeutics→032020Effect of a Leucine/Pyridoxine Nutraceutical on Caloric Intake and Body Composition of Obese Dogs Losing Weight.Frontiers in veterinary science→042020Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.Journal of medicinal food→052019Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters.Obesity (Silver Spring, Md.)→062019Call for Special Issue Papers: Obesity.Journal of medicinal food→072019Call for Special Issue Papers: Obesity.Journal of medicinal food→082019Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes.International journal of molecular sciences→092018Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.Alimentary pharmacology & therapeutics→102017Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice.American journal of cardiovascular disease→112017Erratum: Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice.American journal of cardiovascular disease→122016A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice.International journal of hepatology→132016Activation of the AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans.Metabolism: clinical and experimental→142015Interaction between metformin and leucine in reducing hyperlipidemia and hepatic lipid accumulation in diet-induced obese mice.Metabolism: clinical and experimental→152015Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism.Diabetes, metabolic syndrome and obesity : targets and therapy→162015Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.Metabolism: clinical and experimental→172014Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes.Journal of nutrition and metabolism→182014Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes.PloS one→192013Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity.Diabetes, metabolic syndrome and obesity : targets and therapy→202013Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects.Diabetes, metabolic syndrome and obesity : targets and therapy→212012Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice.Nutrition & metabolism→222012Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects.Nutrients→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

NuSirt

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.