Circadian

fatigue risk management, shift scheduling, sleep education

software data

2 Main Street Suite 340 Stoneham MA 02180 USA·Founded 1983

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-MMEV

Summary · Eternal Search editorial

Circadian fatigue risk management, shift scheduling, sleep education

Circadian provides consulting, software, training, publications, and risk assessment tools for businesses operating around the clock. Its services address shift scheduling, fatigue risk management systems, employee training, corporate sleep programs, and human fatigue expert witness testimony. The site states that since 1983 it has worked with thousands of shift work operations across industries including aviation, mining, manufacturing, healthcare, energy, and transportation.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite21

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Circadian — Far from goals · Bottom quartile. Derived deterministically from 4 extracted project(s). Most-advanced status: undisclosed. Band: far. Modifiers: +5 depth (4 programs at undisclosed).…

Source: Deterministic

At a glance

HQ2 Main Street Suite 340 Stoneham MA 02180 USA

Founded1983

Publications

80 on file

012026Measurement Method Influences the Interpretated Effect of Oral ...biorxiv→022026Design and Recruitment for the Comparative Effectiveness of Zolpidem/Trazodone and Cognitive Behavioral Therapy for Insomnia (COZI) Study in Rural Adults.Behavioral sleep medicine→032026Fatigue Risk Management Solutions: Why Some Look Good on Paper - but Fail in Practice—→042026REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function.Proceedings of the National Academy of Sciences of the United States of America→052026Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK.Proceedings of the National Academy of Sciences of the United States of America→062026Circadian limbic and thalamic beta oscillations drive slow-adapting dual-threshold adaptive deep brain stimulation in Tourette syndrome.Biomedical physics & engineering express→072025Stable and dynamic gene expression patterns over diurnal and developmental timescales in Arabidopsis thaliana.The New phytologist→082025Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy.Journal of sleep research→092025Consistent Direction Despite Wavering Policy: Reductions in Resident Physician Extended Duration Shifts Over 20 Years.The American journal of medicine→102025Astrocyte Fabp7 modulates nocturnal seizure threshold and activity-dependent gene expression in mouse brain.PNAS nexus→112025Vagal impairment and cardiovascular risk in those with zero to low coronary artery calcification scores: the Multi-Ethnic Study of Atherosclerosis.American journal of physiology. Heart and circulatory physiology→122025Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort.JAMA network open→132025Epileptiform Activity and Seizure Risk Follow Long-Term Non-Linear Attractor Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany)→142025Resident Physician Intentions Regarding Unionization.JAMA network open→152025Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.bioRxiv : the preprint server for biology→162025Peripheral Blood DNA Methylation Changes in Response to Centella asiatica Treatment in Aged Mice.Biology→172025Characterizing 24-Hour Skeletal Muscle Gene Expression Alongside Metabolic and Endocrine Responses Under Diurnal Conditions.The Journal of clinical endocrinology and metabolism→182025An encompassing Mendelian randomization study of the causes and consequences of major depressive disorder.Nature. Mental health→192025Circadian rhythm dysfunction and clinical heterogeneity in pediatric ADHD: A critical need for innovation in assessment and treatment.JCPP advances→202025Fecal microbiota transplantation fails to impart the benefits of circadian-dependent intermittent fasting following ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism→212025A circadian morning complex modulates far-red light signaling in Arabidopsis.Nature communications→222025Genomic patterns of strain-specific genetic structure, linkage, and selection across fall armyworm populations.BMC genomics→232025The experiences of night shift workers following three different dietary weight loss interventions: a qualitative study using behaviour change theory.The international journal of behavioral nutrition and physical activity→242025Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes.Neuromolecular medicine→252025The molecular circadian clock: From fundamental mechanisms to therapeutic promise in neurological disorders.Advanced drug delivery reviews→262024Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders.Research square→272024Timely Questions Emerging in Chronobiology: The Circadian Clock Keeps on Ticking.Journal of circadian rhythms→282024AgRP neurons encode circadian feeding time.Nature neuroscience→292024Psychomotor Vigilance Testing on Neonatal Transport: A Western Australian Experience.Air medical journal→302024Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration.JCI insight→312024Causes and consequences of major depressive disorder: An encompassing Mendelian randomization study.medRxiv : the preprint server for health sciences→322024Circadian-Dependent Intermittent Fasting Influences Ischemic Tolerance and Dendritic Spine Remodeling.Stroke→332024Genetic and functional adaptations and alcohol-biased signaling in the mediodorsal thalamus of alcohol dependent mice.bioRxiv : the preprint server for biology→342024Permanent standard time is the optimal choice for health and safety: an American Academy of Sleep Medicine position statement.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine→352024Reflections on Several Landmark Advances in Circadian Biology.Journal of circadian rhythms→362024Sleep and circadian rhythm disturbances as risk and progression factors for multiple chronic overlapping pain conditions: a protocol for a longitudinal study.Pain reports→372024Public opinion of resident physician work hours in 2022.Sleep health→382024Accuracy of Three Commercial Wearable Devices for Sleep Tracking in Healthy Adults.Sensors (Basel, Switzerland)→392024Prospective Bidirectional Relationship Between Sleep Duration and Posttraumatic Stress Disorder Symptoms After Suspected Acute Coronary Syndrome.Psychosomatic medicine→402024Cooling lactating sows exposed to early summer heat wave alters circadian patterns of behavior and rhythms of respiration, rectal temperature, and saliva melatonin.PloS one→412024Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.Nature genetics→422024Identification of sleep and circadian alternative polyadenylation sites associated with APA-linked human brain disorders.Research square→432024Complex epistatic interactions between ELF3, PRR9, and PRR7 regulate the circadian clock and plant physiology.Genetics→442024Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation.Epilepsia→452024Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders.Npj biological timing and sleep→462023Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency.The Journal of general virology→472023Adenosine Kinase regulates Sleep Timing and the ... - bioRxivbiorxiv→482023Sex-specific regulation of the cortical transcriptome in response to sleep deprivation.Frontiers in neuroscience→492023Resting-state background features demonstrate multidien cycles in long-term EEG device recordings.Brain stimulation→502023Perinatal intermittent hypoxia increases early susceptibility to ANG II-induced hypertension in adult male but not in female Sprague-Dawley rats.American journal of physiology. Renal physiology→512023Beyond the symptom: the biology of fatigue.Sleep→522023FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function.Frontiers in systems neuroscience→532023Magnitude of parathyroid hormone elevation in primary hyperparathyroidism: Does time of day matter?Surgery→542023National improvements in resident physician-reported patient safety after limiting first-year resident physicians' extended duration work shifts: a pooled analysis of prospective cohort studies.BMJ quality & safety→552023Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection.iScience→562023NSAIDs use history: impact on the genome-wide DNA methylation profile and possible mechanisms of action.Clinical and experimental medicine→572023An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.Neuron→582023A competition-attenuation mechanism modulates thermoresponsive growth at warm temperatures in plants.The New phytologist→592023Early time-restricted feeding improves high-density lipoprotein amount and function in nonhuman primates, without effects on body composition.Obesity (Silver Spring, Md.)→602023The multiple roles of salt-inducible kinases in regulating physiology.Physiological reviews→612023Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice.Biology open→622023The Mycoplasma hyorhinis genome displays differential chromatin accessibility.Heliyon→632023Resting-state background features demonstrate multidien cycles in long-term EEG device recordings.medRxiv : the preprint server for health sciences→642023Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium.Anesthesia and analgesia→652023The effect of intrinsically photosensitive retinal ganglion cell (ipRGC) stimulation on axial length changes to imposed optical defocus in young adults.Journal of optometry→662023Impact of work schedules of senior resident physicians on patient and resident physician safety: nationwide, prospective cohort study.BMJ medicine→672022Investigating the genetic pathways of insomnia in Autism Spectrum Disorder.Research in developmental disabilities→682022On the surface or down below: Field observations reveal a high degree of surface activity in a burrowing crayfish, the Little Brown Mudbug (Lacunicambarus thomai).PloS one→692022Lighting the Patient Room of the Future: Evaluating Different Lighting Conditions From the Patient Perspective.HERD→702022The COVID-19 pandemic and sleep medicine: a look back and a look ahead.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine→712022REVEILLE 7 inhibits the expression of the circadian clock gene EARLY FLOWERING 4 to fine-tune hypocotyl growth in response to warm temperatures.Journal of integrative plant biology→722022Measuring Hypocotyl Length in Arabidopsis.Methods in molecular biology (Clifton, N.J.)→732022Paclitaxel chemotherapy disrupts behavioral and molecular circadian clocks in mice.Brain, behavior, and immunity→742022Spatially specific mechanisms and functions of the plant circadian clock.Plant physiology→752022Annotation of putative circadian rhythm-associated genes in Diaphorina citri (Hemiptera: Liviidae).GigaByte (Hong Kong, China)→762022Photic Entrainment of the Circadian System.International journal of molecular sciences→772022Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories.Aging cell→782022The Effect of Light Therapy on Electroencephalographic Sleep in Sleep and Circadian Rhythm Disorders: A Scoping Review.Clocks & sleep→792022TIME FOR COFFEE regulates phytochrome A-mediated hypocotyl growth through dawn-phased signaling.The Plant cell→802022Circadian disruption of hippocampus in an early senescence male mouse model.Pharmacology, biochemistry, and behavior→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Circadian

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.