Minicircle

plasmid gene therapy, non-viral delivery

deliverydeliveringgene therapy

minicircle.io·

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-GLOS

Summary · Eternal Search editorial

Minicircle plasmid gene therapy, non-viral delivery

Minicircle describes itself as a gene therapy platform offering investigational plasmid gene therapies through independent international partner clinics. Its Follistatin therapy is presented as a non-viral, non-heritable, subcutaneous treatment intended to support lean muscle, vitality, body composition, and epigenetic age. The site also lists Klotho as coming in 2026.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite4

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Minicircle — Translational · Bottom quartile. Derived deterministically from 10 extracted project(s). Most-advanced status: phase 1. Band: translational. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webminicircle.io

Publications

7 on file

012026DNA deformability in sequence-dependent capture of E. coli gyrase.Nature communications→022026Supercoiled DNA recognition and cleavage control in topoisomerase VI.Nature communications→032025DNA deformability defines sequence-dependent capture of E. coli gyrase.Research square→

042021Follistatin plasmid therapy extends mouse lifespan by 32.5%—→

052020Mitochondrial genomes of Columbicola feather lice are highly fragmented, indicating repeated evolution of minicircle-type genomes in parasitic lice.PeerJ→062014Coexistence of minicircular and a highly rearranged mtDNA molecule suggests that recombination shapes mitochondrial genome organization.Molecular biology and evolution→072011Mitochondrial genome deletions and minicircles are common in lice (Insecta: Phthiraptera).BMC genomics→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Minicircle

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.