Circumvent Pharma

precision medicines, palmitoylome modulation, neurodegeneration

modulatingsmall molecule

circumventpharmaceuticals.com·Portland, Oregon, United States·

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-VWJZ

Summary · Eternal Search editorial

Circumvent Pharma precision medicines, palmitoylome modulation, neurodegeneration

Circumvent was formed to develop precision medicines for neurodegenerative disease, beginning with Batten Disease. The company focuses on diseases with predictive animal models, clear clinical development paths, and the potential to reach market quickly. Its work in Batten Disease has produced insights into brain-cell dysfunction, palmitoylation, the palmitoylome, and synaptic biology that it is applying across related neurological diseases.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite8

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Circumvent Pharma — Early mechanism · Bottom quartile. Derived deterministically from 3 extracted project(s). Most-advanced status: preclinical. Band: early_mechanism. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webcircumventpharmaceuticals.com

HQPortland, Oregon, United States

Publications

80 on file

012026Amorphization Strategy to Circumvent the Oxo Wall for Generating Active Co(IV)═O Species in Fenton-Like Reactions.Angewandte Chemie (International ed. in English)→022026Inhibition of NAMPT targets DNA damage response to sensitize alkylating chemotherapy in TP53 mutant mantle cell lymphoma.Blood advances→032026TCR T cells targeting IgA- and IgG-expressing multiple myeloma.Blood→042026Antibody-Drug Conjugates Targeting Resistance-Associated Signaling Pathways: Recent Advances and Future Perspectives.International journal of molecular sciences→052026Advances in site-specific knock-in techniques for gene editing.Yi chuan = Hereditas→062026Optimization of strain-correlated electronic modulation and interfacial microenvironment for oxide-shielded PdGa nanosheets toward bifunctional electrocatalysis.Journal of colloid and interface science→072026Synthetic control of implanted engineered liver tissue growth.Science advances→082026Recent development in PDE4D-targeted inhibitors for Alzheimer's disease therapy.European journal of medicinal chemistry→092026Lactobacillus acidophilus-Derived Cell-Free Supernatant Augments Methylene Blue-Mediated Photodynamic Inactivation Efficacy Against Methicillin Resistant Staphylococcus aureus Planktonic Suspension and Biofilms.Probiotics and antimicrobial proteins→102026A ferroelectrics/oxide heterojunction based memristor for artificial synapse and neuromorphic computing.Journal of colloid and interface science→112026Spin-state engineering of cobalt(IV)-oxo enables direct oxygen atom transfer for high-efficiency olefin epoxidation.Proceedings of the National Academy of Sciences of the United States of America→122026A hybrid transformer-BiLSTM model optimized with Firefly Algorithm for network traffic anomaly detection.PloS one→132026Directed evolution of functional intrinsically disordered proteins.Nature chemical biology→142026Antibacterial properties and mechanisms of anti-lipopolysaccharide factor 1 from Procambarus clarkii.Fish & shellfish immunology→152026Spatial Patterning of Modular Gelatin-Peroxide Microspheres in Melt-Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity.Advanced healthcare materials→162026Isoxazolines and a meta-diamide are effective mosquito larvicides against Aedes aegypti, Anopheles quadrimaculatus, and Culex quinquefasciatus.Journal of medical entomology→172026Discovery of novel quinazoline analogs as tubulin inhibitors targeting the colchicine binding site for potent antitumor therapy in combination with PD-L1 inhibitors.Bioorganic chemistry→182026Critical quantum metrology robust against dissipation and nonadiabaticity.Science advances→192026Macrophage-delivered Nifuroxazide reprograms immunosuppressive microenvironment and synergizes with oxaliplatin for enhanced anti-hepatocellular carcinoma therapy.Journal of nanobiotechnology→202026Electronically driven soliton-like thermal pulses.Nature communications→212026Asy-RPA/PCR combined with One-crRNA-CRISPR/Cas12a for simultaneous detection of multiple Clarithromycin resistance mutations in Helicobacter pylori.Nanomedicine : nanotechnology, biology, and medicine→222026Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity.Cell reports→232026High-efficiency, double-tapered 3 × 1 mid-infrared tellurite fiber combiner with brightness recovery capability.Optics express→242026The histone-modified landscape: Core mechanisms of osimertinib resistance in EGFR-mutant lung cancer.Cancer letters→252026Dynamic interfacial anchoring in core-shell MoS2-coated Sn anodes enables ultrastable lithium storage.Journal of colloid and interface science→262026Intrathecal Isoniazid and Dexamethasone Therapy May Improve Outcomes in Patients with Tuberculous Meningitis: A Two-Center Retrospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America→272026Photothermal Sensitive Nano Heterojunction Triggering Ferroptosis and PANoptosis for Improving Tumor Immunotherapy.Advanced materials (Deerfield Beach, Fla.)→282026BMAL1 Drives Cisplatin Resistance in Non-Small Cell Lung Cancer Via Lactate-MRP1 Signaling Pathway.Thoracic cancer→292026Construction of hollow fiber stirring bar based on dummy molecularly imprinted polymers for the selective determination of organophosphorus pesticides in food samples.Analytical methods : advancing methods and applications→302026Smart Multimodal Optical Film from Visible-Light-Excited Phosphorescent Materials for Daytime Light Intensity Modulation and Nighttime Traffic Safety.ACS applied materials & interfaces→312026CRISPR/Cas9-engineered universal CD123/B7-H3 tandem CAR-T cell for the treatment of acute myeloid leukemia.Chinese medical journal→322026Hybrid Integration of Tunnel-Junction InGaN/GaN and Wafer-Bonded AlGaInP/GaInP for Full-Color Micro-LEDs.ACS applied materials & interfaces→332026Unlocking Self-Luminescence of Pyrene-Based Metal-Organic Gel for Sensitive Electrochemiluminescence Assay of Microplastics.Analytical chemistry→342026Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA-Protein Interactions.Angewandte Chemie (International ed. in English)→352026Tougu Xiaotong capsules inhibit lung cancer and gefitinib-resistant cells by blocking ERBB2/PI3K-AKT-mTOR signaling and triggering ferroptosis.Phytomedicine : international journal of phytotherapy and phytopharmacology→362026Synthetic Control of Implanted Engineered Liver Tissue Growth.bioRxiv : the preprint server for biology→372026Limitation-circumventing and strength-capitalizing hydrogel potentiates durable antitumor immunity and robust abscopal effect in radiotherapy.Theranostics→382026Dental mesenchymal stem cell-derived exosomes for oral diseases: Classification, functionalization and clinical prospects.Colloids and surfaces. B, Biointerfaces→392026Rationally engineered cationic ferritin nanoparticles overcome pre-existing immunity to adenoviral vectors.Journal of nanobiotechnology→402026Evolutionary transfer learning enables organism-wide inference of mammalian enhancer landscapes.bioRxiv : the preprint server for biology→412026Enhancement of Monascus Azaphilone Pigments Production Without Citrinin Contamination by Targeting Overexpression of Histone Acetyltransferase MrEsa1 and Deletion of Polyketide Synthase PksCT.Journal of fungi (Basel, Switzerland)→422026Remodeling the pathological airway: advanced nanotechnology for diagnostics and therapeutics in cystic fibrosis.Journal of nanobiotechnology→432026Highly efficient single-layer color-tunable QLEDs enables by the real-time interface exciplex modulation with AgInZnS QDs.Science bulletin→442026Ferrous fluoride nanoinitiators reprogram tumor stemness to empower ultrasound-augmented pyroptosis for potent catalytic immunotherapy.Biomaterials→452026Prompt mechanisms in medical imaging: A comprehensive survey.Innovation (Cambridge (Mass.))→462026Formulation considerations in enhancing olfactory mucosal deposition for nose-to-brain drug delivery.Drug delivery and translational research→472026Magnon Torques Mediated by Orbital Hybridization at the Light Metal-Antiferromagnetic Insulator Interface.Physical review letters→482026Mechanisms of Chlorella vulgaris adaptation to dimethyl phthalate-induced toxicity: Focus on the role of photoregulation in metabolic reprogramming.Journal of hazardous materials→492026Dual-B-Site Strategy Underpins Stable Unimodal Deep-Blue Emitting Perovskites.Advanced materials (Deerfield Beach, Fla.)→502026Disability-Free Survival: A Novel Morbidity Endpoint for Older Adult Allogeneic Hematopoietic Cell Transplantation.Transplantation and cellular therapy→512026Influence of social media channels on tobacco product consumption behaviors in people aged 18-30 years.Frontiers in public health→522026Large-scale synthesis of gallic acid-derived carbon quantum dots as efficient photodynamic antimicrobial materials.Biomedical physics & engineering express→532026Liposomal bupivacaine versus standard ropivacaine for pain control in adults receiving continuous supraclavicular brachial plexus blocks for open elbow arthrolysis: study protocol for a randomised controlled non-inferiority clinical trial.BMJ open→542026LDN-57444 sensitizes hepatocellular carcinoma cells to sorafenib by promoting ferroptosis through histone deacetylase 2 (HDAC2) inhibition.Biology direct→552025Type VII secretion system deploys an active iron uptake pathway to enhance bacterial fitness and counteract host nutritional immunity.mBio→562025A review: advances of resveratrol co-delivery biomaterials-based system in anti-tumor therapy.Journal of materials science. Materials in medicine→572025Mitigating voltage degradation in anion exchange membrane water electrolyzers by membrane-electrode interface engineering.Chemical communications (Cambridge, England)→582025Highly elastic and breathable PTFE/hydrogel hierarchically compounded dressings for multi-functional protection and rapid wound healing.Materials horizons→592025Structure-Based Design of a Highly Potent Dual-Competitive FTO Inhibitor for Targeted m6A Demethylase Inhibition in AML.Journal of medicinal chemistry→602025High-Capacity and Long-Life Aqueous Zn-SPAN Batteries with Tandem Catalysis.Advanced materials (Deerfield Beach, Fla.)→612025Recent advances in dual-signal mode sensing detection in food safety, future sensing form with improved accuracy.Critical reviews in food science and nutrition→622025Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli.Journal of medicinal chemistry→632025Designing a DNA synchronizer for compact single-rail DNA logic circuits.Science advances→642025Ultrastable Insulin-Glucagon Fusion Protein Exploits an Endogenous Hepatic Switch to Mitigate Hypoglycemic Risk.ACS pharmacology & translational science→652025Digital Phenotyping of Sensation Seeking: A Machine Learning Approach Using Gait Analysis.Behavioral sciences (Basel, Switzerland)→662025Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.Redox biology→672025Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice.eLife→682025Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5.Frontiers in immunology→692025Advances in nanoplatform-based multimodal combination therapy activating STING pathway for enhanced anti-tumor immunotherapy.Colloids and surfaces. B, Biointerfaces→702025Brønsted acid-promoted ethylene dimerization to 1-butene over Ni-containing zeolite catalysts.Chemical science→712025Research progress of lung organoids in infectious respiratory diseases.European journal of pharmacology→722025Enhanced specific energy in fast-charging lithium-ion batteries negative electrodes via Ti-O covalency-mediated low potential.Nature communications→732025Resistance to naive and formative pluripotency conversion in RSeT human embryonic stem cells.Stem cells (Dayton, Ohio)→742025Artri King induced Cushing syndrome in an 82-year-old man.Dermatology online journal→752025Dual Inhibition of CDK4/6 and CDK7 Suppresses Triple-Negative Breast Cancer Progression via Epigenetic Modulation of SREBP1-Regulated Cholesterol Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany)→762025Emerging insights into intravital imaging, unraveling its role in cancer immunotherapy.Cancer immunology, immunotherapy : CII→772025Efficacy and Safety of Cefuroxime-Tetracycline-Containing Bismuth Quadruple Therapy for Helicobacter pylori Eradication in Penicillin-Allergic Patients: A Multicenter Randomized Controlled Trial.Helicobacter→782025Electronic and optical properties of CrI3/Nb3Cl8heterojunction: a first principles investigation.Journal of physics. Condensed matter : an Institute of Physics journal→792025Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice.bioRxiv : the preprint server for biology→802025A critical role for Vibrio parahaemolyticus LPS to mediate evasion of host immune response during infection.Proceedings of the National Academy of Sciences of the United States of America→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Circumvent Pharma

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.