Biophytis

AI drug discovery, BIO101, longevity therapeutics

modulatingsmall molecule

biophytis.com·Paris, France·Public

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-4REZ

Summary · Eternal Search editorial

Biophytis AI drug discovery, BIO101, longevity therapeutics

Biophytis is a biotechnology company developing transformative therapies impacting longevity. Its strategy includes a longevity research platform using multiple technologies accelerated by AI, plus BIO101 clinical programs in sarcopenia and obesity. The site describes BIO101 in sarcopenia as the most advanced clinical program in the world in sarcopenia.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite14

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Biophytis — Near-term readout · Bottom quartile. Derived deterministically from 6 extracted project(s). Most-advanced status: phase 3. Band: near_readout. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webbiophytis.com

HQParis, France

StagePublic

Publications

28 on file

012025Drug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27.Journal of cachexia, sarcopenia and muscle→022025BIO101 in Sarcopenic Seniors at Risk of Mobility Disability: Results of a Double-Blind Randomised Interventional Phase 2b Trial.Journal of cachexia, sarcopenia and muscle→032025Modulation of the renin-angiotensin system against COVID-19: A path forward?International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases→042025Characterizing sarcopenia and sarcopenic obesity in patients aged 65 years and over, at risk of mobility disability: a multicenter observational trial (SARA-OBS).BMC geriatrics→052025Neuroprotective Effect of Mas Activation by BIO101 in Vincristine-Induced Small Fiber Neuropathy.Journal of the peripheral nervous system : JPNS→062024BIO101 stimulates myoblast differentiation and improves muscle function in adult and old mice.Journal of cachexia, sarcopenia and muscle→072024RAR Inhibitors Display Photo-Protective and Anti-Inflammatory Effects in A2E Stimulated RPE Cells In Vitro through Non-Specific Modulation of PPAR or RXR Transactivation.International journal of molecular sciences→082024Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial.EClinicalMedicine→092023Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD).International journal of molecular sciences→102023A Phase 1 study for safety and pharmacokinetics of BIO101 (20-hydroxyecdysone) in healthy young and older adults.Journal of cachexia, sarcopenia and muscle→112023Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A.The journals of gerontology. Series A, Biological sciences and medical sciences→122023Optimizing the Design of Clinical Trials to Evaluate the Efficacy of Function-Promoting Therapies.The journals of gerontology. Series A, Biological sciences and medical sciences→132022Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance.Magnetic resonance in chemistry : MRC→142021Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients.Drug discovery today→152021The complex metabolism of poststerone in male rats.The Journal of steroid biochemistry and molecular biology→162021Testing the efficacy and safety of BIO101, for the prevention of respiratory deterioration, in patients with COVID-19 pneumonia (COVA study): a structured summary of a study protocol for a randomised controlled trial.Trials→17202120-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor.Journal of molecular endocrinology→182021A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality.Emerging microbes & infections→19202120-Hydroxyecdysone, from Plant Extracts to Clinical Use: Therapeutic Potential for the Treatment of Neuromuscular, Cardio-Metabolic and Respiratory Diseases.Biomedicines→202021A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin.Aging→212021Ecdysteroid metabolism in mammals: The fate of ingested 20-hydroxyecdysone in mice and rats.The Journal of steroid biochemistry and molecular biology→222020Small-scale analysis of phytoecdysteroids in seeds by HPLC-DAD-MS for the identification and quantification of specific analogues, dereplication and chemotaxonomy.Phytochemical analysis : PCA→232020Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.Aging→242020Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors.Oxidative medicine and cellular longevity→252018Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma.Oncotarget→262016Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.PloS one→272015The minor ecdysteroids from Ajuga turkestanica.Phytochemical analysis : PCA→282014Quinoa extract enriched in 20-hydroxyecdysone affects energy homeostasis and intestinal fat absorption in mice fed a high-fat diet.Physiology & behavior→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Biophytis

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.