Cambrian Bio

aging biology, mTORC1 inhibition, AMPK activation

modulatingsmall molecule

cambrianbio.com·New York, New York·Series C Plus·$62M total funding

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-NBUC

Summary · Eternal Search editorial

Cambrian Bio aging biology, mTORC1 inhibition, AMPK activation

Cambrian Bio is a clinical-stage drug development company focused on therapeutics to treat and ultimately prevent debilitating chronic diseases. The company targets biological pathways and mechanisms that decline or malfunction with age. Cambrian operates a distributed company model with multiple pipeline programs and PipeCos developed centrally by its R&D team and collaborators.

The published score reflects a curated read of public evidence across 16 dimensions. Each dimension below shows the rationale we used. Disagree with a reading? Tell us where we are wrong →

Plate C·01 · Scientific profile

All 16 dimensions
on the record.

Composite21

Chain scale100 pts

Dimensions16

Plate C·02 · Where it sits among peers

Score vs. proximity
to longevity goals.

Higher up = higher Eternal Search score. Further right = closer to achieving real longevity outcomes (early mechanism → translational → near-term readout). Bubble size = capital deployed. Watch for MISMATCHES: big bubbles on the left are well-capitalized but far from goals; small bubbles on the right are doing more with less.

Reading

Cambrian Bio — Translational · Bottom quartile. Derived deterministically from 10 extracted project(s). Most-advanced status: phase 1. Band: translational. Aging-relevance not LLM-reviewed in this pass.

Source: Deterministic

At a glance

Webcambrianbio.com

HQNew York, New York

StageSeries C Plus

Publications

68 on file

012025Thermal taphonomy experiments challenge ultrastructural preservation in the Chengjiang yunnanozoans.Proceedings. Biological sciences→022025Unveiling the early evolution of black corals.Communications biology→032025Exploring Secure Recovery Knowledge, Skills, and Education Needs of Forensic Staff.The journal of the American Academy of Psychiatry and the Law→042025Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps.eLife→052025Recommendations for biomarker data collection in clinical trials by longevity biotechnology companies.npj aging→062025Restoration of Cambrian Paleogeomorphology and Its Geological Significance in the Tabei Area, Tarim Basin.ACS omega→072025An extinct clade of the basal Epitheliozoa: phylogenetic position and implication of the enigmatic Cambrian chancelloriids.Communications biology→082024A human pluripotent stem cell-derived in vitro model of the blood-brain barrier in cerebral malaria.Fluids and barriers of the CNS→092024Bioremediation of acid mine drainage using sulfate-reducing wetland bioreactor: Filling substrates influence, sulfide oxidation and microbial community.Chemosphere→102024Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.Aging→112024Transformation of iron-minerals from natural aquifer media by sulfate-reducing bacteria: Behavior, mechanism, and Cr(VI) removal.The Science of the total environment→122024Molting in early Cambrian armored lobopodians.Communications biology→132024Biogenic Sulfide-Mediated Iron Reduction at Low pH.Microorganisms→142024Early evolution of the ecdysozoan body plan.eLife→152023A New Chengjiang Worm Sheds Light on the Radiation and Disparity in Early Priapulida.Biology→162023Defining a longevity biotechnology company.Nature biotechnology→172023High and low permeability of human pluripotent stem cell-derived blood-brain barrier models depend on epithelial or endothelial features.FASEB journal : official publication of the Federation of American Societies for Experimental Biology→182023Aldanella attleborensis (Mollusca) from Cambrian Stage 2 of the Three Gorges Area and Its Stratigraphic Implications.Biology→192023Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor.Nature cell biology→202022Ultrastructure reveals ancestral vertebrate pharyngeal skeleton in yunnanozoans.Science (New York, N.Y.)→212022Ocruranus-Eohalobia Sclerites from the Cambrian Stage 2 Yanjiahe Formation in South China: Scleritome Reconstruction and Zoological Affinity.Biology→222022A call for better understanding of target engagement in Tau antibody development.Drug discovery today→232022An hiPSC-Derived In Vitro Model of the Blood-Brain Barrier.Methods in molecular biology (Clifton, N.J.)→242022Dawn of complex animal food webs: A new predatory anthozoan (Cnidaria) from Cambrian.Innovation (Cambridge (Mass.))→252022Muscle systems and motility of early animals highlighted by cnidarians from the basal Cambrian.eLife→262022Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) into Endothelial-Type Cells and Establishment of an In Vitro Blood-Brain Barrier Model.Methods in molecular biology (Clifton, N.J.)→272022QSAR model to predict Kp,uu,brain with a small dataset, incorporating predicted values of related parameter.SAR and QSAR in environmental research→282022Recognition of Rare Microfossils Using Transfer Learning and Deep Residual Networks.Biology→292022Author Correction to: Tube-dwelling in early animals exemplified by Cambrian scalidophoran worms.BMC biology→302022Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.Pharmaceutical research→312021Tube-dwelling in early animals exemplified by Cambrian scalidophoran worms.BMC biology→322021Advanced Cambrian hydroid fossils (Cnidaria: Hydrozoa) extend the medusozoan evolutionary history.Proceedings. Biological sciences→332021Strategies for delivering therapeutics across the blood-brain barrier.Nature reviews. Drug discovery→342021Fossil evidence unveils an early Cambrian origin for Bryozoa.Nature→352021Mariana-type ophiolites constrain the establishment of modern plate tectonic regime during Gondwana assembly.Nature communications→362020Cuticular reticulation replicates the pattern of epidermal cells in lowermost Cambrian scalidophoran worms.Proceedings. Biological sciences→372020Macrofaunal control of microbial community structure in continental margin sediments.Proceedings of the National Academy of Sciences of the United States of America→382020On the origin of vertebrate body plan: Insights from the endoderm using the hourglass model.Gene expression patterns : GEP→392020Evolutionary trade-off in reproduction of Cambrian arthropods.Science advances→402019Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs.Neuroscience bulletin→412019Origin of ecdysis: fossil evidence from 535-million-year-old scalidophoran worms.Proceedings. Biological sciences→422019Sclerite-bearing annelids from the lower Cambrian of South China.Scientific reports→432018Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems.Drug discovery today→442018Establishment of a Human iPSC- and Nanofiber-Based Microphysiological Blood-Brain Barrier System.ACS applied materials & interfaces→452018Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients.Fluids and barriers of the CNS→462017Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.Nature cell biology→472017Orthrozanclus elongata n. sp. and the significance of sclerite-covered taxa for early trochozoan evolution.Scientific reports→482017Three Cambrian fossils assembled into an extinct body plan of cnidarian affinity.Proceedings of the National Academy of Sciences of the United States of America→492017Meiofaunal deuterostomes from the basal Cambrian of Shaanxi (China).Nature→502016Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System.Molecular pharmaceutics→512016Examining the Uptake of Central Nervous System Drugs and Candidates across the Blood-Brain Barrier.The Journal of pharmacology and experimental therapeutics→522015A vanished history of skeletonization in Cambrian comb jellies.Science advances→532015Lower Cambrian polychaete from China sheds light on early annelid evolution.Die Naturwissenschaften→542014An early Cambrian agglutinated tubular lophophorate with brachiopod characters.Scientific reports→552014Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow.Cell stem cell→562013Early Cambrian pentamerous cubozoan embryos from South China.PloS one→572013A sclerite-bearing stem group entoproct from the early Cambrian and its implications.Scientific reports→582012Evidence for gill slits and a pharynx in Cambrian vetulicolians: implications for the early evolution of deuterostomes.BMC biology→592011An armoured Cambrian lobopodian from China with arthropod-like appendages.Nature→602011A stem-group cnidarian described from the mid-Cambrian of China and its significance for cnidarian evolution.Nature communications→612010Epibionts on the lingulate brachiopod Diandongia from the Early Cambrian Chengjiang Lagerstatte, South China.Proceedings. Biological sciences→622010The earliest history of the deuterostomes: the importance of the Chengjiang Fossil-Lagerstatte.Proceedings. Biological sciences→632010Tiny sea anemone from the Lower Cambrian of China.PloS one→642006Lower Cambrian vendobionts from China and early diploblast evolution.Science (New York, N.Y.)→652003A new species of yunnanozoan with implications for deuterostome evolution.Science (New York, N.Y.)→662003Head and backbone of the Early Cambrian vertebrate Haikouichthys.Nature→672001Primitive deuterostomes from the Chengjiang Lagerstätte (Lower Cambrian, China).Nature→682001An Early Cambrian tunicate from China.Nature→

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Cambrian Bio

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

Loading

All 16 dimensionson the record.

Score vs. proximityto longevity goals.

Publications

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.

All 16 dimensions
on the record.

Score vs. proximity
to longevity goals.