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plasmid gene therapy, non-viral delivery
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C-GLOSC-GLOSplasmid gene therapy, non-viral delivery
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The purpose of this study is to investigate the safety and efficacy of a combination klotho and follistatin gene therapy, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of this gene therapy.
The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.
Billionaire are heading deep in the Caribbean, Roatán is home to Prospera, a futuristic city where the ultra-wealthy are undergoing experimental gene therapy to reverse aging, grow muscle, and even extend their lifespan! This secretive haven has no medical regulations, ultra-low taxes, and cutting-edge biotech treatments that are BANNED in the U.S. One of the most shocking treatments? Follistatin gene therapy – a $25,000 DNA injection designed to supercharge the body's ability to regenerate. Tech billionaire Bryan Johnson has already undergone the procedure, claiming it’s slowing his aging process dramatically. But is this the future of humanity—or a dangerous playground for the rich? 🤔 From biohackers injecting themselves with experimental DNA to ultra-rich investors building a city without rules, this video uncovers the truth behind Prospera, Minicircle’s gene therapy, and the controversial quest for human immortality. Would YOU try gene therapy to live longer? Let us know in the
#What #Minicircle #Bryan 🌟 Welcome to [Funny Vibes] - Unleashing the Ultimate Entertainment Extravaganza! 🎉 🚀 About Us: Get ready for a rollercoaster of joy, laughter, and non-stop entertainment at [Funny Vibes]. We're not just a channel; we're a front-row seat to the most thrilling show in town! Join our ever-growing community of entertainment aficionados who believe that life's too short for anything less than constant fun. 🎥 What We Offer: 🌈 A Feast of Fun: Indulge in a smorgasbord of entertainment! From side-splitting comedy sketches to heartwarming moments and jaw-dropping challenges, our channel is a vibrant mosaic of laughter and joy. 💡 Smart and Snappy: Stay in the loop with our witty take on the latest trends, news, and pop culture. We're not just keeping you informed; we're doing it with a dash of humor that will leave you grinning from ear to ear. 🎬 Step Into the Screen: Immerse yourself in experiences that go beyond the ordinary.
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visit www.desci.nyc for the latest events -------------------- Dr. Ryan Rossner is the Director of Longevity at Minicircle, a leading company in gene therapies. Gene therapy is a specialized form of medicine that introduces new genetic material into a person's cells to replace faulty or missing genes, or to enhance the body's natural ability to combat diseases. Tech mogul Bryan Johnson has undergone follistatin gene therapy as part of his exploration into extending human lifespan beyond 120 years. Presented by: DeSciNYC and SVN Schedule: 7:00-8:00 PM: Networking 8:00-8:30 PM: Main talk 8:30-9:30 PM: More chatting 🐦Stay Connected about Future Events: Twitter: @descinyc Instagram: @descinyc PS: Apply to be a member of the DeSci NYC group chat: https://forms.gle/AmUtotmCgWgGxWDp6
Full Episode: https://youtu.be/wVAVizZzSfw Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one might want to consider when deciding whether to partake in a n
Full Episode: https://youtu.be/wVAVizZzSfw Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one might want to consider when deciding whether to partake in a n
Full Episode: https://youtu.be/wVAVizZzSfw Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one might want to consider when deciding whether to partake in a n
Full Episode: https://youtu.be/wVAVizZzSfw Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one might want to consider when deciding whether to partake in a n
Full Episode: https://youtu.be/wVAVizZzSfw Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one might want to consider when deciding whether to partake in a n
🧬🔬 New details on Minicircle’s follistatin gene therapy that Bryan Johnson reported injecting himself with — from a recent interview by their cofounder and CSO Walter Patterson with Iosif Gershteyn. I was particularly interested in learning more about their kill switch. Here’s the full interview with Walter Patterson by Cognitum’s Iosif Gershteyn: https://youtube.com/watch?v=BFqCLiZ-oC4 Here’s Bryan Johnson’s video about getting the Minicircle follistatin gene therapy at Prospéra in Honduras: https://youtube.com/watch?v=bax8to_s07Q
This is a clip taken from episode 50 of The Optispan Podcast | Full Episode: https://youtu.be/wVAVizZzSfw Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one
This is a clip taken from episode 50 of The Optispan Podcast | Full Episode: https://youtu.be/wVAVizZzSfw Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one
Subscribe to our channel: https://www.youtube.com/@matt.kaeberlein Check out the Bryan Johnson video: https://www.youtube.com/watch?v=bax8to_s07Q Last month, entrepreneur and venture capitalist Bryan Johnson released a Youtube video detailing his trip to Prospera, Honduras to receive follistatin gene therapy from the Minicircle Gene Therapy clinic. Bryan describes Minicircle's gene therapy as "a pioneering technology with the potential to improve muscle and strength, slow the speed of aging, and many more benefits". In this episode, Matt reacts in real time to his first watch of Bryan's video and responds to Nick's questions about various topics that come up along the way. He provides a primer on gene therapy and its potential as a longevity intervention, discusses the clinical evidence for follistatin's effects on humans and model organisms, and goes through several things one might want to consider when deciding whether to partake in a new therapy. He also gives his honest take on
I flew to Honduras for a gene therapy that might change the future of humanity. Thank you to our friends at Minicircle for their groundbreaking work: https://minicircle.clinic/ 🥦 Order the Blueprint Stack: https://blueprint.bryanjohnson.com/?&utm_source=youtube&utm_medium=video&utm_content=bax8to_s07Q 🫒 Blueprint Extra Virgin Olive Oil - https://blueprint.bryanjohnson.com/products/premium-extra-virgin-olive-oil/?&utm_source=youtube&utm_medium=video&utm_content 🍫 Blueprint Cocoa - https://blueprint.bryanjohnson.com/products/cocoa-powder/?&utm_source=youtube&utm_medium=video&utm_content ❓WHAT IS BLUEPRINT I’ve invested millions of dollars building the world’s leading anti-aging protocol, becoming the most measured human in history. Blueprint is an algorithm, built by science, that takes better care of me than I can myself. And it’s available to you for free. Check out the Blueprint website for recipes, exercise, and other protocols. Become the next evolution of human: https:
Learn Everything you need to know about Bryan Johnson´s new Gene Therapy. Time Stamps: 01:00 - Próspera (Roatán) - A libertarian City 01:30 - Mini Circle - Gene Therapy Biotech Company 02:40 - Gene Therapy Explained! 06:50 - Risks of Gene Therapy 08:03 - Follistatin Explained 08:20 - Mini Circle Follistatin Gene Therapy Explained 13:07 - Follistatin Extends Life Span #biohacking #biohackingtips #antiaging #biotechnology #health #próspera #minicircle #geneediting #genetherapy References Jaijyan, Dabbu Kumar, et al. "New intranasal and injectable gene therapy for healthy life extension." Proceedings of the National Academy of Sciences 119.20 (2022): e2121499119. Video Edited with CapCut Music from Epidemic Sounds Videos from Pixels Images created with Canva Images obtained from Freepik. Icons were obtained from Flaticon and created by Eucalyp, Flat Icons, Smashicons, hqrloveq, kliwir art, Pixel perfect, Paul J., Dimas Anom, Smashicons, monkik, Surang, Roundicons, Amonrat Rungreangfa
From August 20th to 26th, a cohort of young men and women took a journey to the Honduran island of Roatán. But it wasn't just any tourist trip. This group of friends travelled from the United States to participate in the first clinical trial for an experimental genetic editing therapy in the Caribbean Island's semi-autonomous zone called Próspera. For years, Mac Davis, Walter Patterson, and Tristan Roberts have worked on medical treatments including gene therapies in the United States, largely escaping the purview of the FDA by experimenting on themselves. High profile experiments they attempted included gene therapies for HIV and Herpes in 2017 and 2018, which caught the attention of international media and spawned programs on Netflix and Showtime. Those experiments were put on hold following the high-profile but unrelated death of their partner and investor at the time, Aaron Traywick. In the time since then, Davis, Patterson, and Roberts have founded MiniCircle Inc and changed th
This study examines the safety and effects of an injectable plasmid gene therapy. Plasmids are circular pieces of DNA which have been widely studied as a non-permanent \& non-heritable method for transferring genes and inducing gene expression. In this study the plasmid is a gene vector which contains the human FST344 gene intended to express and secrete bioidentical human follistatin into serum circulation. Follistatin is a myostatin and activin inhibitor that has demonstrated improved functional outcomes in mouse models of neuromuscular disease. Participants will undergo dual energy x-ray absorptiometry scans before and after the treatment's administration to compare change from baseline and rates of change in fat vs muscle tissue and bone density. Participants will also undergo metabolic and epigenetic blood panels to observe any changes. Participants will be monitored at the clinic site for a short time period after receiving the therapy and participants will be able to report any adverse events through an online form. Lastly, participants will have blood drawn just prior to, and three months after, the gene therapy's administration in order to assess circulating levels of follistatin. This study is administered at the Global Alliance for Regenerative Medicine clinical research site on the island of Roatan and is sponsored by Minicircle. The main contact for this study is Mac Davis.
This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity” | MIT Technology Review You need to enable JavaScript to view this site. Skip to Content MIT Technology Review Featured Topics Newsletters Events Audio MIT Technology Review Featured Topics Newsletters Events Audio Biotechnology and health This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity” A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio. By Jessica Hamzelou ar
Biohackers Convene in Honduras for Unregulated Gene Therapy Trials Without FDA Oversight Aging & Longevity News Life Extending Tech Supplements & Drugs NAD⁺ Precursors Metabolic Regulators Senolytics Sirtuin Modulators Lifestyle Optimization Dietary Choices Physical Activity Sleep Optimization Next-Gen Therapeutics Gene Therapy Cellular Reprogramming Everything About NAD⁺ What is NAD⁺? What does NAD⁺ do? How to increase NAD⁺? NAD⁺ vs NADH NMN and NR: NAD⁺ Precursors Aging Research Aging & Longevity Brain & Neurons Cardiovascular Immunity Cancer Clinical Trials Longevity Prescri
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Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in Mice Minicircle DNA-Engineered CAR T Cells Suppressed Tumor Growth in Mice Mol Cancer Ther . 2020 Jan;19(1):178-186. doi: 10.1158/1535-7163.MCT-19-0204. Epub 2019 Oct 3. Authors Jinsheng Han # 1 , Fei Gao # 1 2 , Songsong Geng 3 , Xueshuai Ye 1 3 , Tie Wang 4 , Pingping Du 3 , Ziqi Cai 3 , Zexian Fu 3 5 , Zhilong Zhao 3 6 , Long Shi 3 7 , Qingxia Li &nbs
Newsletter September 2025 | BioAustinCTX Member Login 0 Items About About Us Central Texas Life Leadership Legacy Leaders Membership Membership Class Membership Access Benefits Membership Benefits Discount Programs Service Get Involved Sponsorships Partners Resources Newsletters Events Announcements Select Page Newsletter September 2025 Thanks to Our New and Renewing Members Minicircle Emerald Cloud Lab, Inc Versiti Alex Rodriguez Weeks Ilya Pyatnitskiy Marc Adesso Learn More About Membership IN THIS NEWSLETTER SPOTLIGHT LOCAL EVENTS LOCAL NEWS INDUSTRY RESOURCES CAREER CORNER VOLUNTEER OPPORT … d us your job postings, news, resources and events to share with the community. Submit your information today to be a part of next month’s newsletter. SPOTLIGHT Join Us for BioBash 2025 at the New UT Discovery to Impact Innovation Lab! BioAustinCTX is proud to partner with the University of Texas Discovery to Impact Innovation Lab and Karlin Real Estate to bring you this year’s BioBash. Mark your calendars for Thursday, November 6, from 6:00 – 9:00 p.m. , and be among t … hanks to our Platinum Sponsors UPCOMING EVENTS Local Events Sept 9 5:30-9:30 PM Award for Innovation in Healthcare & Bioscience Join us on September 9 from 5:30 to 9:00pm at the Tobin Center for the Performing Arts for an exclusive event that brings together leaders from San Antonio’s largest economic sector to celebrate excellence, innovation, and impact in health. Dr. Larry Schlesinger, President and CEO of Texas Biomedical Research Institute, will be recognized for his … dent and CEO of University Health, will receive BioMedSA’s Lifetime Achievement Award. His enduring contributions to public health and healthcare access have left a lasting legacy in San Antonio and beyond. Sept 17 5 PM IPAustin Meet-up Join us at the IPAustin Meet-up for a refreshing blend of innovation, insight, and hops. Whether you’re a founder, inventor, or just IP-curious, this is your chance to tap into expert advice on the top questions you should be asking your … orate venture groups at Texas’s premier conference for life science innovation. Apply by September 26 to be considered. Early bird tickets are also available—reserve your spot today and be part of the conversation shaping the future of healthcare. Oct 1 1-7:30 PM THBI Fall Policy Summit and Luminary Awards Dinner The Fall Policy Summit and Lumina
Gene Therapy Company Minicircle Launches Premium Website with Fixel | Vin Thomas posted on the topic | LinkedIn LinkedIn respects your privacy LinkedIn and 3rd parties use essential and non-essential cookies to provide, secure, analyze and improve our Services, and to show you relevant ads (including professional and job ads ) on and off LinkedIn. Learn more in our Cookie Policy . Select Accept to consent or Reject to decline non-essential cookies for this use. You can update your choices at any time in your settings . Accept Reject Agree & Join LinkedIn By clicking Continue to join or sign in
Webinar Virus Free Gene Modification With Minicircle Dna For Advanced Cell Therapies – PlasmidFactory GmbH PlasmidFactory Logo PlasmidFactory Custom DNA Custom DNA Our manufacturing service for your custom DNA, tailored to your requirements – available in Research grade, CCC grade, High Quality (HQ) grade, and GMP grade. Plasmid DNA Production of your plasmid DNA with our optimized manufacturing workflows and customized solutions after pre-order consultation. Minicircle DNA A minimal, supercoiled monomeric circular expression cassette with your gene of interest, free of bacterial backbone, pro … . Schleef (2021), Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification. Microbial Cell Factories M. Izco, J. Blesa, M. Schleef, M. Schmeer, R. Porcari, R Al-Shawi, S. Ellmerich, M. de Toro, C. Gardiner, Y. Seow, A. Reinares.Sebastian, R. Forcen, JP. Simons, V. Belotti, JM. Cooper, L. Alvarez-Erviti (2019), Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology. Molecular Therapy T. Buchholz, M. Schleef (201
Bio International Convention 2025 – PlasmidFactory GmbH PlasmidFactory Logo PlasmidFactory Custom DNA Custom DNA Our manufacturing service for your custom DNA, tailored to your requirements – available in Research grade, CCC grade, High Quality (HQ) grade, and GMP grade. Plasmid DNA Production of your plasmid DNA with our optimized manufacturing workflows and customized solutions after pre-order consultation. Minicircle DNA A minimal, supercoiled monomeric circular expression cassette with your gene of interest, free of bacterial backbone, providing demonstrated advantages over conventional pl … ion or contact us at [email protected] to discuss how we can support your application. Read more Further news & events May 11 – 15, 2026 Boston, MA ASGCT Annual Meeting 2026 in Boston Read more March 26 – 26, 2026 17:00 CET / 16:00 GMT / 11:00 EST / 08:00 PST Webinar - Why DNA Quality Matters – from Research to GMP Read more March 17 – 18, 2026 London, UK Advanced Therapies 2026 in London Read more December 10 – 10, 2025 17:00 CET / 16:00 GMT / 11:00 ET / 08:00 PT Webin … . Schleef (2021), Recombinant expression of Barnase in Escherichia coli and its application in plasmid purification. Microbial Cell Factories M. Izco, J. Blesa, M. Schleef, M. Schmeer, R. Porcari, R Al-Shawi, S. Ellmerich, M. de Toro, C. Gardiner, Y. Seow, A. Reinares.Sebastian, R. Forcen, JP. Simons, V. Belotti, JM. Cooper, L. Alvarez-Erviti (2019), Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology. Molecular Therapy T. Buchholz, M. Schleef (201
Find a Minicircle Clinic | Global Gene Therapy Locations Therapies Our Technology Follistatin Klotho Locations About Our Story Clinic Partners Press Success Stories Get Started Toggle mobile menu Therapies Our Technology Follistatin Klotho Locations Explore Locations About Our Story Clinic Partners Press Success Stories Get Started Find a clinic. Global Alliance for Regenerative Medicine (GARM) Paradise Island, Bahamas Visit Website Global Alliance for Regenerative Medicine (GARM) Roatán, Honduras Visit Website Xtend Optimal Health Center Panama City, Panama Visit Website Offer Minicircle to y
About Minicircle | Leaders in Advanced Gene Therapy for Human Enhancement Therapies Our Technology Follistatin Klotho Locations About Our Story Clinic Partners Press Success Stories Get Started Toggle mobile menu Therapies Our Technology Follistatin Klotho Locations Explore Locations About Our Story Clinic Partners Press Success Stories Get Started Align your biology to your ambitions. We develop plasmid gene therapies to help people do what they love for longer. Meet our founding team. Mac Davis Founder & Chief Executive Officer View Bio Details Modal for Mac Davis Walter Patterson Found
Become a Minicircle Clinic Partner | Offer Advanced Gene Therapies Therapies Our Technology Follistatin Klotho Locations About Our Story Clinic Partners Press Success Stories Get Started Toggle mobile menu Therapies Our Technology Follistatin Klotho Locations Explore Locations About Our Story Clinic Partners Press Success Stories Get Started Become a clinic partner to access the latest innovations in gene therapy. Get started Why work with us? We partner with licensed clinics to offer investigational gene therapies under responsible medical supervision. Join a select roster of clinics. We part
Minicircle in the Media | News, Features & Expert Interviews Therapies Our Technology Follistatin Klotho Locations About Our Story Clinic Partners Press Success Stories Get Started Toggle mobile menu Therapies Our Technology Follistatin Klotho Locations Explore Locations About Our Story Clinic Partners Press Success Stories Get Started Featured Minicircle featured in the Netflix Documentary “Don’t Die: The Man Who Wants to Live Forever” View on Netflix Featured In “The DNA of Things with Dr. Jeremy Koenig” Minicircle CEO Mac Davis speaks about Self-Experimentation and Plasmid G
Minicircle | Gene Therapy for Longevity, Performance & Wellness Therapies Our Technology Follistatin Klotho Locations About Our Story Clinic Partners Press Success Stories Get Started Toggle mobile menu Therapies Our Technology Follistatin Klotho Locations Explore Locations About Our Story Clinic Partners Press Success Stories Get Started Unlock the power of your genes. Plasmid gene therapy that supports your healthiest future. Get Started As seen on the Netflix documentary “Don’t Die: The Man Who Wants to Live Forever” As seen on the Netflix documentary “Don’t Die: The Man Who Wants to Li