EGEN-5784 porcine liver with metra ELC device
phase 1drug program · high · Mon Jun 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Support liver function during treatment in participants with Grade 2 to Grade 3 acute-on-chronic liver failure and hepatic encephalopathy.
First-in-human Phase 1 safety and proof-of-concept study using a genetically engineered porcine liver with a modified metra extra-corporeal liver cross-circulation device.
Phase 1 clinical trial record published for EGEN-5784 liver plus metra ELC device.
No clinical results are provided in the supplied trial record. Related review notes whole-organ extracorporeal liver perfusion reports where more than half of severe patients were bridged to transplantation and survived without porcine retrovirus transmission, but this is not stated as EGEN-5784-specific efficacy.
Extracorporeal liver xenotransplant support program
phase 1drug program · high · Mon Jun 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Provide temporary liver support for participants with Grade 2 to Grade 3 acute-on-chronic liver failure and hepatic encephalopathy.
Genetically engineered EGEN-5784 porcine liver used with the modified metra extra-corporeal liver cross-circulation device.
Phase 1 first-in-human safety, proof-of-concept study listed for EGEN-5784 porcine liver with the metra ELC device.
No company-specific clinical results reported in the supplied material; broader artificial liver support literature calls for further development of extracorporeal liver support systems.
Gene-edited pig cardiac xenotransplantation for infants
preclinicalresearch program · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess gene-edited pig hearts as a bridge to allotransplantation for critically ill infants who are poor candidates for mechanical support.
Pig-to-baboon orthotopic cardiac xenotransplantation model using genetically engineered infantile pig hearts, CD40/CD154 costimulation pathway blockade, rapamycin, and transition of selected recipients to allotransplantation.
2025 publication reporting progress in a pig-to-baboon infant cardiac xenotransplantation model.
In 15 orthotopic cardiac xenotransplants, 8 of 15 baboons survived more than 1 month, 6 survived more than 3 months, the longest survivor lived more than 24 months post-xenotransplantation, and no significant xeno- or allo-sensitization was reported during xenograft support.
Kidney xenotransplant program
phase 1drug program · high · Wed Sep 04 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Develop a human-compatible engineered porcine kidney for transplantation in patients with kidney failure and organ shortage.
Multiplex genome engineering of porcine donors, including endogenous retroviral inactivation, triple gene knockout, and human transgene insertion, applied to kidney xenotransplantation.
Cleared for a Phase 1/2/3 kidney transplant trial; Series D proceeds announced to advance EGEN-2784.
Published evidence includes human porcine kidney xenotransplantation and clinical/infectious-disease management experience from the first human porcine kidney transplant.
Karius infectious disease surveillance collaboration
exploratorybiomarker · medium · Tue Apr 11 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Accelerate xenotransplantation by supporting infectious disease surveillance for patients receiving organ transplants.
Partnership with Karius for pathogen detection or infectious disease monitoring in xenotransplantation contexts.
Karius and eGenesis announced a partnership on April 11, 2023.
Related supplied publication describes donor screening, pathogen mitigation, recipient monitoring, infection prevention, and infectious complication management for the first human porcine kidney transplant.
Tegoprubart xenotransplantation collaboration
preclinicalresearch program · medium · Mon Jan 09 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate tegoprubart for use in preclinical xenotransplantation studies involving eGenesis programs.
Collaboration with Eledon Pharmaceuticals to use tegoprubart in preclinical xenotransplantation studies.
eGenesis and Eledon announced the collaboration on January 9, 2023.
Human-compatible genome-engineered porcine organ platform
preclinicalplatform · high · Sun Jan 01 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Create human-compatible porcine donor organs for xenotransplantation by addressing safety and efficacy barriers including endogenous retroviruses and immune compatibility.
Extensive germline genome engineering in pigs, inactivation of porcine endogenous retroviruses, and design/testing of humanized porcine donors with multiple genetic edits.
Published design and testing of a humanized porcine donor for xenotransplantation and prior extensive germline genome engineering/PERV inactivation work.
Supplied publications support the feasibility of engineered porcine donors, including PERV inactivation, extensive pig genome engineering, and humanized donor design/testing; detailed platform-wide performance metrics are not provided in the supplied material.
EGEN-2784 genetically engineered porcine-derived kidney
phase 1drug program · high
Evaluate a human-compatible genetically engineered porcine-derived kidney for patients with end-stage kidney disease.
Genome-engineered porcine kidney xenotransplantation; company states the FDA cleared an IND for a Phase 1/2/3 trial.
FDA-cleared IND to initiate a Phase 1/2/3 clinical trial in end-stage kidney disease.
Related supplied publications report clinical xenotransplantation experience, infectious disease surveillance, and porcine kidney transplantation for end-stage kidney disease, but no EGEN-2784 trial outcomes are provided.
Heart xenotransplant program
preclinicaldrug program · high
Develop gene-edited porcine hearts for cardiac xenotransplantation, including potential bridge-to-allotransplantation use in infants.
Orthotopic cardiac xenotransplantation from genetically engineered infantile pigs into size-matched baboons, with immunosuppression based on CD40/CD154 costimulation pathway blockade and rapamycin.
Preclinical pig-to-baboon studies reported for gene-edited pig cardiac xenotransplantation as a bridge to allotransplantation in infants.
In the supplied abstract, 8 of 15 baboons survived more than one month, 6 survived more than three months, the longest survivor lived more than 24 months, and no significant xeno- or allo-sensitization was observed during xenograft support.
Multiplex genome-engineered human-compatible organ platform
preclinicalplatform · high
Create human-compatible engineered porcine organs and cells to address organ failure and donor shortages.
Multiplex genome engineering in porcine donors, including porcine endogenous retrovirus inactivation, triple gene knockout, and human transgene insertion.
Platform supports listed kidney, liver, and heart transplant programs and is backed by publications on extensive germline genome engineering, PERV inactivation, and humanized porcine donor design.
Supplied publications report genome-wide PERV inactivation, extensive germline genome engineering in pigs, and design/testing of a humanized porcine donor for xenotransplantation.
