Human MGE-type GABAergic interneuron development and maturation atlas
preclinicalresearch program · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Characterize human stem cell-derived medial ganglionic eminence-type inhibitory interneurons for regenerative cell therapy applications and drug-resistant epilepsy treatment.
Xenograft hPSC-derived MGE-pINs into mouse hosts and analyze development over time using single-nuclei RNA sequencing, transcriptomic comparison, electrophysiology, and morphology.
2025 Neuron publication reporting subtype diversity and gradual electrochemical maturation of grafted human GABAergic interneurons.
Grafted cells developed predominantly into SST and PVALB interneuron subtypes, with sequential transcriptional states involving migration, synapse organization, and membrane maturation.
NRTX-1001 for drug-resistant bilateral mesial temporal lobe epilepsy
phase 1drug program · high · Thu Nov 14 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate safety and preliminary efficacy of NRTX-1001 administered into both temporal lobes for subjects with drug-resistant bilateral mesial temporal lobe epilepsy.
Multicenter, single-arm, open-label Phase 1/2 clinical trial of single-administration inhibitory interneuron cell therapy into both temporal lobes.
Phase 1/2 bilateral MTLE clinical trial listed on ClinicalTrials.gov.
NRTX-1001 for drug-resistant unilateral mesial temporal lobe epilepsy
phase 1drug program · high · Thu Jun 16 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Test whether a single intracerebral administration of inhibitory GABAergic interneurons can safely reduce seizure frequency in drug-resistant unilateral mesial temporal lobe epilepsy, with or without mesial temporal sclerosis.
Image-guided intracerebral administration of NRTX-1001, a human interneuron cell therapy that secretes GABA, in a Phase 1/2 clinical trial.
Phase 1/2 EPIC clinical trial listed for drug-resistant unilateral MTLE.
Nav1.1-overexpressing interneuron transplant program for Alzheimer's disease models
preclinicalresearch program · medium · Mon Jan 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess whether interneuron transplantation can restore brain rhythms and cognition in an Alzheimer's disease mouse model.
Transplant Nav1.1-overexpressing interneurons into a mouse model of Alzheimer's disease and evaluate effects on brain rhythms and cognition.
2018 preclinical publication reporting restored brain rhythms and cognition in a mouse model.
Publication title reports restoration of brain rhythms and cognition after Nav1.1-overexpressing interneuron transplants in an Alzheimer's disease mouse model.
Interneuron cell therapy research for spinal cord injury pain and bladder dysfunction
preclinicalresearch program · medium · Fri Jan 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time)
Investigate whether transplanted human stem cell-derived interneuron precursors can reduce central neuropathic pain and bladder dysfunction after spinal cord injury.
Transplant human stem cell-derived interneuron precursors in mouse spinal cord injury models and assess bladder dysfunction and central neuropathic pain.
2016 preclinical publication on mitigation of bladder dysfunction and central neuropathic pain after spinal cord injury.
Publication title reports mitigation of mouse bladder dysfunction and central neuropathic pain after spinal cord injury.
Allogeneic neural cell therapy platform
undisclosedplatform · medium
Create targeted neural cell therapies to repair dysfunctional neural circuits in chronic nervous system disorders.
Manufacture fully differentiated neuronal, glial, and gene-edited cell therapy candidates for targeted delivery into the nervous system.
Platform supports clinical-stage NRTX-1001 and broader neuronal, glial, and gene-edited cell therapy candidates.
