FOXO3 Activator Screening Research
exploratoryIdentify compounds with health-promoting properties that can induce FOXO3 activity, supporting FOXO3-focused longevity and age-related disease therapeutic discovery.
Screening compounds for FOXO3 nuclear translocation and FOXO-dependent transcriptional activation; mechanistic analysis of PI3K/AKT signaling, CRM1-mediated nuclear export, DYRK1A inhibition, ROS production, and sirtuin involvement.
Publication reported screening results for resveratrol, piperlongumine, and harmine in 2022.
Resveratrol, piperlongumine, and harmine induced FOXO3 nuclear translocation. Piperlongumine and harmine activated FOXO-dependent transcription, while resveratrol did not. Harmine's effect was reported to be partially mediated through DYRK1A inhibition and reversible by sirtuin inhibition.