Type 2 diabetes serum proteome study
exploratoryresearch program · medium · Tue Mar 19 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Investigate proteomic differences between patients with type 2 diabetes and matched controls and identify potential therapeutic targets or biomarker associations.
High-precision label-free bottom-up LC-MS/MS proteomics of individual serum samples, analyzing proteins, peptides, and post-translational modifications without prior assumptions.
BioRxiv preprint published in 2024 reporting serum proteome findings in type 2 diabetes and BMI-associated proteomic signals.
Serum proteomes were very similar at the protein level across 175 proteins; fasting glucose associated with glycations of abundant serum proteins; ALS, IGFBP-3, and IGF-2 were strongly negatively associated with BMI.