Canine aging multi-omics research
exploratoryresearch program · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Identify molecular aging signatures in dogs and assess whether canine aging pathways overlap with conserved human aging mechanisms.
Gene expression and plasma protein abundance profiling in whole blood and blood plasma from young, old, and geriatric laboratory beagles.
Published 2025 GeroScience study reporting canine aging signatures across transcriptomic and proteomic data.
Identified 816 genes and 40 proteins that changed with age, converging on DNA repair, collagen processing, and inflammation; signatures overlapped with human age-associated genes.
Canine Frailty and Healthspan Assessment Program
exploratoryresearch program · medium · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess frailty, health-related quality of life, declining physical function, and broader canine geriatric syndrome as outcome frameworks for aging dogs.
Frailty instruments, health-related quality-of-life assessment, multicenter cross-sectional study designs, and geriatric syndrome framework development.
2025 publication on assessing frailty in senior dogs, following 2022 studies and reviews on healthspan instruments, physical function, canine geriatric syndrome, and the aging phenotype in dogs.
Supplied titles indicate development and evaluation of tools and frameworks for measuring healthspan, frailty, physical function, and geriatric syndrome in companion dogs.
Canine metabolic aging biomarker research
exploratorybiomarker · medium · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Characterize age-related metabolic markers associated with frailty and reduced quality of life in dogs.
Research assessing insulin, adiponectin, and lipid concentrations with age and their association with frailty and quality of life.
Publication listed in 2025 on age-related insulin, adiponectin, and lipid changes in dogs.
The supplied title states that changes in insulin, adiponectin, and lipid concentrations with age are associated with frailty and reduced quality of life in dogs.
Canine metabolic aging model research
exploratoryresearch program · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Characterize metabolic changes relevant to canine aging and frailty, including insulin, adiponectin, lipid concentrations, dyslipidemia, hyperinsulinemia, and insulin resistance.
Observational and experimental veterinary geroscience studies, including high-fat diet induction of metabolic changes similar to natural aging.
Published 2024 study on high-fat diet metabolic aging model and 2025 study linking metabolic biomarkers with frailty and quality of life.
High-fat diet induced dyslipidemia, hyperinsulinemia, and peripheral insulin resistance similar to natural aging; age-related insulin, adiponectin, and lipid changes were associated with frailty and reduced quality of life.
Canine Metabolic Aging Research Program
exploratoryresearch program · medium · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Characterize metabolic changes associated with aging, frailty, and reduced quality of life in dogs, including insulin, adiponectin, lipid concentrations, dyslipidemia, hyperinsulinemia, and peripheral insulin resistance.
Observational and dietary-model research using canine metabolic markers and high-fat diet-induced metabolic change studies.
2025 publication on insulin, adiponectin, and lipid concentrations associated with frailty and reduced quality of life in dogs; 2024 publication on high-fat diet-induced metabolic changes similar to natural aging.
Supplied publication titles report associations between age-related metabolic markers and frailty/reduced quality of life, and that high-fat diet can induce aging-like metabolic changes in dogs.
Senior dog frailty and healthspan assessment research
exploratoryresearch program · medium · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Develop and evaluate ways to assess frailty, healthspan, physical function, and quality of life in aging companion dogs.
Frailty, health-related quality of life, and physical-function assessment research in senior and companion dogs.
Multiple publications listed from 2022 to 2025 on assessing frailty, healthspan instruments, canine geriatric syndrome, and declining physical function in aging dogs.
Supplied publication titles indicate research linking canine aging with frailty, quality of life, physical decline, and geriatric syndrome frameworks.
Senior dog frailty and quality-of-life assessment research
exploratoryresearch program · high · Wed Jan 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Assess frailty, healthspan, physical function, and quality of life in senior companion dogs to support veterinary geroscience outcomes.
Frailty, HRQL, phenotype, and physical-function assessment studies in aging dogs.
Multiple publications from 2022 through 2025 on canine frailty, HRQL, aging phenotype, and declining physical function.
LOY-001
undiscloseddrug program · medium
Develop a longevity drug program for large and giant dogs.
Veterinary drug program listed in Loyal's pipeline for large and giant dogs.
Listed as a pipeline program on Loyal's products page.
LOY-002
undiscloseddrug program · high
Extend lifespan in senior dogs while maintaining quality of life by targeting metabolic dysfunction associated with aging.
Canine longevity drug program targeting metabolic dysfunction in senior dogs; evaluated through Loyal's clinical development and conditional approval pathway.
FDA Center for Veterinary Medicine accepted the Reasonable Expectation of Effectiveness section of Loyal's conditional approval application for LOY-002.
Loyal's submitted data were reported to provide reasonable expectation of LOY-002's intended effect, but detailed efficacy results were not supplied.
LOY-003
undiscloseddrug program · medium
Develop a longevity drug program for large and giant dogs.
Veterinary drug program listed in Loyal's pipeline for large and giant dogs.
Listed as a pipeline program on Loyal's products page.
STAY clinical trial
undisclosedresearch program · medium
Evaluate Loyal's canine longevity intervention in dogs through a multi-clinic veterinary clinical trial.
Clinical trial conducted across veterinary clinics.
Reported as running across veterinary clinics.
