C-WRZLprotein degradation, small molecules, neurodegeneration
0-100 chain-logic scale · 15 dimensions · scored on public evidence
Develop a disease-modifying therapy for Alzheimer's disease by targeting disease-related proteins.
Protein degrader and/or corrector therapeutic approach.
Listed in Origami Therapeutics' pipeline.
Develop a disease-modifying therapy for amyotrophic lateral sclerosis by targeting disease-related proteins.
Protein degrader and/or corrector therapeutic approach.
Listed in Origami Therapeutics' pipeline.
Develop a disease-modifying therapy for frontotemporal dementia by targeting disease-related proteins.
Protein degrader and/or corrector therapeutic approach.
Listed in Origami Therapeutics' pipeline.
Develop a disease-modifying therapy for Huntington's disease by targeting disease-related proteins.
Protein degrader and/or corrector therapeutic approach.
Listed in Origami Therapeutics' pipeline; dedicated Huntington's disease page identified.
Develop a disease-modifying therapy for Parkinson's disease by targeting disease-related proteins.
Protein degrader and/or corrector therapeutic approach.
Listed in Origami Therapeutics' pipeline.
Develop disease-modifying therapies that target and degrade disease-related proteins while sparing normal forms of the protein in neurodegenerative diseases.
Small-molecule protein degradation and protein correction approach for disease-related protein targets.
Platform described as focused on neurodegenerative diseases including Alzheimer's, Huntington's, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal dementia.