Direction
Measuring ageing
Your birthday counts years. Molecular clocks read changes in your cells. The ambition is to learn whether a treatment changes the course of ageing while there is still time to act.
If a clock runs backwards, does the body work better?
Inside the researchHuman tissue data
In 2013, Steve Horvath built an age predictor from DNA methylation: chemical marks on DNA. It used 353 sites and worked across many human tissues. Ageing could now be studied through a shared molecular readout.
What this leaves open. Predicting age is different from proving rejuvenation. A change in the readout needs to be connected to health and function.
Read the paper ↗DNA methylation age of human tissues and cell typesHorvath · Genome Biology · 2013Companies
Companies in this direction
Ambition is what a company claims. Independent replication is what others have confirmed. Read the two columns together: the gap between them is where a promise runs ahead of a result.
| Company▲ | Ambition▲ | Independent replication▲ | Stage▲ | Headquarters▲ |
|---|---|---|---|---|
| Biotein Biotein is building a low-cost saliva test to measure protein markers of age-related cellular damage. | 5 | 0 | pre seed | – |
| Deep Longevity Deep Longevity provides AI-powered aging clocks and SaaS platforms for biological age prediction and personalized health insights. | 6 | 4 | acquired | Hong Kong |
| Edifice Health Edifice Health provides inflammatory health monitoring tests to help patients and clinicians manage systemic chronic inflammation. | 6 | 4 | – | San Francisco, California, United States |
| Generation Lab Generation Lab offers an epigenetic SystemAge test with personalized insights across 460 biomarkers and 21 organs and systems. | 8 | 1 | – | San Francisco, California, United States |
| Life Length Life Length measures aging and disease biology using telomere, telomerase, oxidative stress, NAD+, and single-cell biomarker diagnostics. | 3 | 2 | – | Madrid, Spain |
| My Aging Tests MyAgingTests provides epigenetic biological age testing and evidence-backed tools for longevity interventions. | 6 | 5 | – | United States |
| Sapere Bio Sapere Bio provides biomarker testing for longevity, immune resilience, cellular senescence, and athletic performance. | 6 | 3 | – | Raleigh-Durham, North Carolina, United States |
| Tally Health Tally Health provides epigenetic age testing, longevity supplements, and personalized insights designed to improve healthspan and longevity. | 6 | 4 | – | United States |
| Vero Biosciences Vero uses proteomics and machine learning to measure organ-level biological age from a single blood draw. | 7 | 1 | – | United States |
Projects
Projects in this direction
| Project▲ | Stage▲ | Strongest case against▲ |
|---|---|---|
| CHANGS CHANGS is a newly announced 2025 Chulalongkorn University-BGI collaboration in Thailand focused on healthy aging, using omics and AI-based bioinformatics to analyze elderly health, collect volunteer samples and clinical data, and reportedly build outputs such as multi-omic aging measures and organ-aging models. | Early-stage and pre-results. | The current evidence is mostly promotional and institution-authored, so the main failure mode is that CHANGS remains a collaboration and training brand without generating validated outputs. |
| Japan Longevity Consortium Japan Longevity Consortium is a Japan-based academic consortium led from Juntendo University that is promoting a biomarker-guided, multi-component “Scientific Zen” healthspan program combining washoku-style diet, mild fasting, exercise, yoga/breathing, TEAS, far-infrared therapy, supplementation, and gut-focused management to improve cognition, immune function, and muscle function. | Early but active. | The central risk is that this is a high-variance wellness bundle with weak causal attribution, optimistic framing, and insufficient external validation. |
People
People in this direction
- Aubrey de Greypopulariser · through Human Longevity Inc.
SENS Foundation founder and longevity advocacy pioneer.
- George Churchscientist · through Generation Lab
Led and founded major synthetic biology and genomics efforts with public work on aging reversal, gene therapy, and longevity biotechnology companies including Rejuvenate Bio.
- Alex Zhavoronkovpopulariser · through Deep Longevity
- Steve Horvathscientist · through My Aging Tests
- Vadim Gladyshevscientist · through Deep Longevity
Redox biologist mapping the mechanisms and signatures of aging
- Eric Verdinscientist · through Edifice Health
- Tony Wyss-Corayscientist · through Vero Biosciences
Neuroscientist decoding how systemic aging affects the brain
- David Sinclairscientist · through Tally Health
- Kelsey Moodyentrepreneur · through Biotein
Drug-development entrepreneur building an integrated longevity biotech platform
- Peter Diamandisentrepreneur · through Human Longevity Inc.
Chronology
What happened, and when
Hypotheses
Hypotheses under test in this direction
Published by the Omega Point engine and tagged to this direction by a classifier; the gap each one attacks is named under it
- Widening blood vessels creates an apparent oxygen loss at skin repair sitesSep 21, 2026The hypothesis says optical readings can fall after local blood vessel widening without reducing oxygen available to repairing skin. Matched heat and pressure tests would distinguish a sampling effect from real harm by comparing optical readings, independent tissue oxygen measurements, and functional recovery.
- Blood antibody tests overstate protection when they do not match tissue infectionSep 21, 2026The hypothesis says blood antibody tests misrepresent protection against tissue infection because they use different pathogen-producing and target cells. Matching those cells and the infection route should remove the discrepancy; continued escape despite a protective matched result would reject it.
- Measurement delays create the appearance of unstable glucose control after muscle restorationSep 20, 2026Stronger insulin responsiveness in restored muscle may appear harmful because sensing and sampling distort glucose timing. Synchronized reference glucose and glucose-flux measurements would distinguish this artifact from growing physiological oscillations.
Forecasts