N-Acetyl-Cysteine for Chemotherapy-Related Cognitive Impairment in Ovarian Cancer
phase 1drug program · high · Fri May 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)
Determine maximum tolerated dose, safety, tolerability, and whether N-acetyl-cysteine can mitigate chemotherapy-related cognitive impairment in ovarian cancer patients receiving platinum-based therapy.
Phase I dose-escalation and Phase II dose-expansion clinical trial adding N-acetyl-cysteine to platinum-based therapy.
Clinical trial record published on 2026-05-01.
Ibogaine Neural Dynamics in Opioid Use Disorder
exploratoryresearch program · high · Mon Sep 08 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Understand whether ibogaine treatment changes brain function, brain chemistry, opioid cue responses, cravings, withdrawal symptoms, mood, anxiety, pain, and quality of life in people with moderate-severe opioid use disorder.
Observational neuroimaging and psychometric study using MRI, MRS, EEG, surveys, and urine testing before and after independently arranged legal ibogaine treatment outside the U.S.
Clinical trial record published on 2025-09-08.
Adjuvant Sacituzumab Govitecan and Nivolumab for High-Risk Muscle-Invasive Urothelial Carcinoma
phase 2drug program · high · Fri Nov 15 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate adjuvant combination therapy in patients with high-risk muscle-invasive urothelial carcinoma after curative-intent surgery.
Single-arm Phase 2 clinical study of sacituzumab govitecan plus nivolumab.
Clinical trial record published on 2024-11-15.
Electroacupuncture for Symptom Management After Cytoreductive Surgery and HIPEC
exploratoryresearch program · high · Sun Sep 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Evaluate feasibility, safety, acceptance, and preliminary effectiveness of electroacupuncture for pain, nausea/vomiting, diarrhea, and insomnia after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, including effects on blood biomarkers.
Clinical study of electroacupuncture symptom management with recruitment, compliance, safety, acceptance, symptom, and biomarker assessments.
Clinical trial record published on 2024-09-01.
Biportal Spinal Endoscopy for Lumbar Pathology in Resource-Limited Hospitals
exploratoryresearch program · high
Evaluate whether biportal spinal endoscopy can be safely and feasibly used to manage lumbar stenosis and disc herniation in rural underserved hospital settings with limited resources.
Case series of endoscopic discectomy and unilateral laminotomy with bilateral decompression using standard orthopedic arthroscopic equipment during a mission trip in Soddo, Ethiopia.
2024 case-series publication reporting 1-year outcomes in five patients.
No complications, postoperative deficits, infections, readmissions, revisions, or wound dehiscence were reported at 12 months; most patients had VAS-back and VAS-leg scores below 2/10 and all returned to work or activities of daily living.
Fasting-Mimicking Diet in Asian Americans With Prediabetes
exploratoryresearch program · medium
Assess feasibility of a larger study and examine preliminary effects of one fasting-mimicking diet cycle on fasting blood glucose, ketone levels, and physical measurements in Asian Americans with prediabetes.
Pilot dietary intervention using one 5-day fasting-mimicking diet cycle with pre- and post-intervention visits, surveys, and metabolic measurements.
Clinical trial record included in supplied public records.
Malaria Elimination Population Genomics Program in Kayin State
exploratoryresearch program · high
Assess how intensive malaria control affects Plasmodium falciparum population genomics under elimination settings and inform future control efforts.
Genomic analysis of 2,270 sequenced P. falciparum infections from 283 malaria posts over 58 months, evaluating parasite population size, resistance allele frequency, relatedness, transmission chains, and mass drug administration effects.
2026 Nature Microbiology publication reporting population genomic changes during a malaria elimination program.
Transmission was reduced by 97%; parasite effective population size decreased; mass drug administration produced founder effects; localized transmission chains remained; artemisinin resistance allele frequency shifted rapidly by 2020.
MTA-Cooperative PRMT5 Inhibitors for MTAP-Deleted Cancers
preclinicaldrug program · high
Discover potent, selective, orally bioavailable inhibitors targeting the PRMT5-MTA complex for treatment of MTAP-deleted cancers while reducing undesirable metabolism and hERG liability.
Medicinal chemistry program using bis-acyl hydrazide PRMT5-MTA inhibitors and deuterium kinetic isotope effect optimization of a methyl-d3 analog.
2026 Journal of Medicinal Chemistry publication describing discovery and optimization of methyl-d3 analog 16.
Methyl-d3 analog 16 reduced formation of a potent hERG-inhibiting metabolite in vivo, producing acceptable safety margins and improved pharmacokinetic profile.
PLG Bridge and Human Neural Stem Cell Therapy for Spinal Cord Injury
preclinicalresearch program · high
Enhance neurorepair after spinal cord injury by improving axon regeneration, myelination, synaptic reconnection, and locomotor recovery.
Temporally layered regenerative approach combining acute multichannel PLG scaffold bridge implantation with chronic human neural stem cell transplantation.
2024 NPJ Regenerative Medicine publication reporting in vitro and in vivo spinal cord injury results.
Combination treatment increased regenerating and myelinated axons, enabled donor-cell migration and integration, supported synaptic circuit formation, and improved locomotor recovery in vivo.
REFANGO Functional Network Alignment Evaluation Platform
exploratoryplatform · high
Provide statistically rigorous evaluation of global protein-protein interaction network alignments using shared Gene Ontology terms.
Combinatorial p-value calculation for shared GO terms in 1-to-1 network alignments, with aggregate significance approximated using Empirical Brown's Method.
2024 Journal of Mathematical Biology publication describing the method.
The method was reported to correlate with precision of GO annotation predictions and provide independent feedback on biological quality of network alignments.
