C-QLGH

FILE C-QLGH·COMPANY·CURATED BY ETERNAL SEARCH

Brain Preservation Foundation

whole brain preservation, aldehyde-stabilized cryopreservation, connectomics

education media

brainpreservation.org·Founded 2010

01Overview 02People 03Projects 04Concepts 05Patents 06Public records 07Belief evolution

Plate C · C-QLGH

Projects

Aldehyde-Stabilized Cryopreservation Support

exploratory

research program · high · Tue Mar 13 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Support and assess aldehyde-stabilized cryopreservation as a brain preservation approach for preserving synaptic and ultrastructural information.

Chemical fixation combined with cryopreservation; evaluated through BPF prize-winning mammal brain preservation entries and public scientific support materials.

ASC was used by 21st Century Medicine in both BPF Small Mammal and Large Mammal Brain Preservation Prize wins.

BPF-linked records state ASC was the method used in both prize-winning small and large mammal preservation demonstrations; BPF did not support offering ASC or any preservation method to human patients as of 2018.

Brain Preservation Prize

exploratory

research program · high · Tue Mar 13 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Evaluate preservation protocols capable of preserving brain-wide 3D ultrastructure and synaptic connectivity in animal brains.

Challenge-prize evaluation of submitted whole-brain preservation protocols, including imaging-based assessment of preserved brain tissue.

21st Century Medicine won the Small Mammal Brain Preservation Prize on 2016-02-09 and the Large Mammal Brain Preservation Prize on 2018-03-13 using aldehyde-stabilized cryopreservation.

Aldehyde-stabilized cryopreservation was reported as the winning method in both the small mammal and large mammal prize phases.

Aspirational Neuroscience Prize

undisclosed

research program · low

Not specified in the supplied material beyond being listed as a BPF prize program.

Prize program; specific evaluation criteria are not described in the supplied material.

Listed on BPF site navigation as an active or historical program page.

Mikula Whole Mouse Brain Evaluation

exploratory

research program · medium

Assess Shawn Mikula's whole mouse brain preservation entry for suitability in the small mammal phase of the Brain Preservation Prize.

Official evaluation of a preserved whole mouse brain using electron micrographs and X-ray micro CT volume imaging at 16 micron voxel resolution.

Mikula submitted a whole mouse brain as an official entry; BPF performed preliminary X-ray micro CT evaluation and noted prior entries had been rejected for preservation damage.

Prior Mikula entries were rejected because BPF found sufficient damage, including large cortical cracks in an imaged brain. The supplied material does not state a final winning result for this entry.

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0-100 chain-logic scale · 15 dimensions · scored on public evidence

Projects

Aldehyde-Stabilized Cryopreservation Support

exploratory

research program · high · Tue Mar 13 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Support and assess aldehyde-stabilized cryopreservation as a brain preservation approach for preserving synaptic and ultrastructural information.

Chemical fixation combined with cryopreservation; evaluated through BPF prize-winning mammal brain preservation entries and public scientific support materials.

ASC was used by 21st Century Medicine in both BPF Small Mammal and Large Mammal Brain Preservation Prize wins.

Brain Preservation Prize

exploratory

research program · high · Tue Mar 13 2018 00:00:00 GMT+0000 (Coordinated Universal Time)

Evaluate preservation protocols capable of preserving brain-wide 3D ultrastructure and synaptic connectivity in animal brains.

Challenge-prize evaluation of submitted whole-brain preservation protocols, including imaging-based assessment of preserved brain tissue.

21st Century Medicine won the Small Mammal Brain Preservation Prize on 2016-02-09 and the Large Mammal Brain Preservation Prize on 2018-03-13 using aldehyde-stabilized cryopreservation.

Aldehyde-stabilized cryopreservation was reported as the winning method in both the small mammal and large mammal prize phases.

Aspirational Neuroscience Prize

undisclosed

research program · low

Not specified in the supplied material beyond being listed as a BPF prize program.

Prize program; specific evaluation criteria are not described in the supplied material.

Listed on BPF site navigation as an active or historical program page.

Mikula Whole Mouse Brain Evaluation

exploratory

research program · medium

Assess Shawn Mikula's whole mouse brain preservation entry for suitability in the small mammal phase of the Brain Preservation Prize.

Official evaluation of a preserved whole mouse brain using electron micrographs and X-ray micro CT volume imaging at 16 micron voxel resolution.

Mikula submitted a whole mouse brain as an official entry; BPF performed preliminary X-ray micro CT evaluation and noted prior entries had been rejected for preservation damage.

Prior Mikula entries were rejected because BPF found sufficient damage, including large cortical cracks in an imaged brain. The supplied material does not state a final winning result for this entry.